Abstract
GİRİŞ ve AMAÇ: Vücut kompozisyonu KOAH hastaları için önemli bir parametredir. Ancak astım ve obezite arasındaki ilişki tam olarak anlaşılamamıştır. Astım şiddetinin vücut yağsız kitlesi (VYK) üzerine etkisi ise araştırılmamıştır. Biz bu çalışmada, VYK ve astım kontrolü arasındaki ilişkiyi araştırmayı amaçladık.
YÖNTEM ve GEREÇLER: Polikliniğe başvuran stabil astım hastaları değerlendirildi. Hastaların demografik bilgileri kaydedildi ve her hasta astım kontrol testi (AKT) ile değerlendirildi. AKT’ye göre hastalar AKT>19 (kontrol altında) ve AKT ≤ 19 (kontrol altında olmayan) şeklinde iki gruba ayrıldı. Vücut kompozisyon değerlendirmesi (biyoelektrik impedans analizi kullanarak) yapıldı.
BULGULAR: Çalışmaya 172 astım hastası (K / E: 140/32, yaş: 53.7 ± 12.6 yıl, VKİ: 29.1 ± 5.4 kg / m2) dahil edildi.VYK, control altındaki astım grubunda control altında olmayan gruba gore anlamlı olarak yüksekti (sırasıyla; 49.8±8.2 vs. 46.7±4.9 p¬=0.002). Ortalama VKİ her iki grupta benzerdi (sırasıyla; 28.6±5.6 vs. 30.2±4.8 p=0.07). Kontrol altında olan ve olmayan astım hastaları arasında obezite (VKİ>30 kg / m2) sıklığı açısından farklılık saptanmadı.
TARTIŞMA ve SONUÇ: VYK, astım kontrolünü değerlendirmede VKİ ve obezite ile karşılaştırıldığında daha değerli bir bulgu olabilir. Bu nedenle VYK ile astım kontrolü arasındaki ilişkiyi araştıran daha fazla çalışma yapılmasına ihtiyaç vardır.
Keywords
References
- Heitmann BL, Erikson H, Ellsinger BM, Mikkelsen KL, Larsson B. Mortality associated with body fat, fat-free mass and body mass index among 60year-old swedish men-a 22-year follow-up. The study of men born in 1913. Int J ObesRelatMetabDisord 2000; 24: 33–7
- Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Carveley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J; Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J RespirCrit Care Med 2007; 176: 532–55.
- Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143–78.
- Vestbo J, Prescott E, Almdal T, Dahl M, Nordestgaard BG, Andersen T, Sørensen TI, Lange P. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. Am J Respir Crit Care Med 2006; 173: 79–83.
- Slinde F, Gronberg A, Engstrom CP, Rossander-Hulthen L, Larsson S. Body composition by bioelectrical impedance predicts mortality in chronic obstructive pulmonary disease patients. Respir Med 2005; 99:1004–9.
- Beckett WS, Jacobs DR Jr, Yu X, Iribarren C, Williams O. Asthma is associated with weight gain in females but not males, independent of physical activity. Am J RespirCrit Care Med 2001; 164: 2045–50.
- Boulet LP. Asthma and obesity. Clin Exp Allergy 2013; 43:8–21.
- Goutaki M, Pescatore AM, Singh P, Beardsmore CS, Kuehni CE. Increased prevalence of pre-school wheeze is not explained by time trends in body mass index. Eur Respir J. 2014; 44: 1078–82.
- Benet M, Varraso R, Kauffmann F, Romieu I, Anto JM, Clavel-Chapelon F, Garcia-Aymerich J. The effects of regular physical activity on adult-onset asthma incidence in women. Respir Med.2011; 105: 1104–7.
- Saint-Pierre P, Bourdin A, Chanez P, Daures JP, Godard P. Are overweight asthmatics more difficult to control? Allergy 2006; 61: 79–84.
- Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB. Development of the Asthma Control Test: a survey for assessing asthma control. J Allergy Clin Immunol 2004; 113: 59-65
- Minas M, Papaioannou AI, Tsaroucha A, Daniil Z, Hatzoglou C, Sgantzos M, Gourgoulianis KI, Kostikas K. Body Composition in Severe Refractory Asthma: Comparison with COPD Patients. PloS One. 2010; 5: e13233
- Chandalia M, Abate N. Metabolic complications of obesity: inflated or inflamed? J Diabetes Complications 2007; 21: 128–36
- Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006; 368: 780–93.
- Bai HJ, Sun JQ, Chen M, Xu DF, Xie H, Yu ZW, Bao ZJ, Chen J, Pan YR, Lu DJ, Cheng S. Age-related decline in skeletal muscle mass and function among elderly men and women in Shanghai, China: a crosssectional study. Asia Pac J Clin Nutr. 2016; 25: 326-32.
Abstract
INTRODUCTION: Body composition is an important parameter for patients with chronic obstructive pulmonary disease (COPD) whereas the association between asthma and obesity is not fully understood. The impact of diseases severity of asthma on fat free mass (FFM) has not been investigated. We aim to investigate the relationship between fat free mass and asthma control.
METHODS: Patients with stable asthma referred to our outpatient clinic were evaluated. Demographics were noted. Asthma control test (ACT) was performed. Patients were divided into two groups according to ACT; ACT >19 (undercontrol) and ACT ≤19 (uncontrolled). Body composition assessment (using bioelectrical impendance analysis) was performed.
RESULTS: One hundred- seventy two patients (F/M: 140/32, age: 53.7±12.6 years, BMI: 29.1±5.4kg/m2 with asthma were included the study. FMM was significantly higher in group under control than uncontrolled group (respectively; 49.8±8.2 vs. 46.7±4.9 p¬=0.002).Mean BMI wassimiliar in twogroups (respectively; 28.6±5.6 vs. 30.2±4.8 p=0.07).There was no difference in the frequency of obesity (BMI>30 kg / m2) between control and non-control patients.
DISCUSSION AND CONCLUSION: FMM may be a more valuable finding in assesing asthma control than BMI and obesity. Further studies should be performed to beter understand the relationship between FFM and asthma control.
Keywords
References
- Heitmann BL, Erikson H, Ellsinger BM, Mikkelsen KL, Larsson B. Mortality associated with body fat, fat-free mass and body mass index among 60year-old swedish men-a 22-year follow-up. The study of men born in 1913. Int J ObesRelatMetabDisord 2000; 24: 33–7
- Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Carveley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J; Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J RespirCrit Care Med 2007; 176: 532–55.
- Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, Gibson P, Ohta K, O'Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008; 31: 143–78.
- Vestbo J, Prescott E, Almdal T, Dahl M, Nordestgaard BG, Andersen T, Sørensen TI, Lange P. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. Am J Respir Crit Care Med 2006; 173: 79–83.
- Slinde F, Gronberg A, Engstrom CP, Rossander-Hulthen L, Larsson S. Body composition by bioelectrical impedance predicts mortality in chronic obstructive pulmonary disease patients. Respir Med 2005; 99:1004–9.
- Beckett WS, Jacobs DR Jr, Yu X, Iribarren C, Williams O. Asthma is associated with weight gain in females but not males, independent of physical activity. Am J RespirCrit Care Med 2001; 164: 2045–50.
- Boulet LP. Asthma and obesity. Clin Exp Allergy 2013; 43:8–21.
- Goutaki M, Pescatore AM, Singh P, Beardsmore CS, Kuehni CE. Increased prevalence of pre-school wheeze is not explained by time trends in body mass index. Eur Respir J. 2014; 44: 1078–82.
- Benet M, Varraso R, Kauffmann F, Romieu I, Anto JM, Clavel-Chapelon F, Garcia-Aymerich J. The effects of regular physical activity on adult-onset asthma incidence in women. Respir Med.2011; 105: 1104–7.
- Saint-Pierre P, Bourdin A, Chanez P, Daures JP, Godard P. Are overweight asthmatics more difficult to control? Allergy 2006; 61: 79–84.
- Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, Murray JJ, Pendergraft TB. Development of the Asthma Control Test: a survey for assessing asthma control. J Allergy Clin Immunol 2004; 113: 59-65
- Minas M, Papaioannou AI, Tsaroucha A, Daniil Z, Hatzoglou C, Sgantzos M, Gourgoulianis KI, Kostikas K. Body Composition in Severe Refractory Asthma: Comparison with COPD Patients. PloS One. 2010; 5: e13233
- Chandalia M, Abate N. Metabolic complications of obesity: inflated or inflamed? J Diabetes Complications 2007; 21: 128–36
- Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006; 368: 780–93.
- Bai HJ, Sun JQ, Chen M, Xu DF, Xie H, Yu ZW, Bao ZJ, Chen J, Pan YR, Lu DJ, Cheng S. Age-related decline in skeletal muscle mass and function among elderly men and women in Shanghai, China: a crosssectional study. Asia Pac J Clin Nutr. 2016; 25: 326-32.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Original Article |
| Authors | |
| Publication Date | April 8, 2020 |
| Submission Date | October 7, 2019 |
| Published in Issue | Year 2020 Volume: 9 Issue: 1 |
