Survival and Prognostic Factors in Adult Low-Grade Gliomas

Year 2016, Volume: 5 Issue: 3, 173 - 180, 01.09.2016

Suheyla Aytaç Arslan Muzaffer Bedri Altundağ Ela Soykut Gonca Altınışık İnan Yıldız Güney

https://doi.org/10.5505/abantmedj.2016.19327

Abstract

INTRODUCTION: The purpose of this study was to evaluate survival in patients with nonpilocytic low-grade gliomas LGGs .METHODS: Records of 70 adult patients with LGGs diagnosed between 2003 and 2007 at Dr Abdurrahman Yurtarslan Oncology, Education and Research Hospital AOH , Ankara, Turkey, were retrospectively reviewed. The Kaplan-Meier method estimated overall survival OS .RESULTS: Median age at diagnosis was 37.5 years range; 20- 73 with a slightly higher male predominance male / female: 1.26 . Median follow-up was 39 range, 4-79 months. Operative pathology revealed pure astrocytoma in 54% oligodendroglioma in 21%, and oligoastrocytoma in 10% of patients. Subtotal resection STR was achieved in 44 patients 63% , gross total resection GTR in 19 27% , and biopsy only in 7 10% . Presenting symptoms in order of frequency were headache, seizure and motor disturbances. Median time interval between surgery and radiotherapy was 7 weeks ranging from 3 to 78. Median OS was 71 months range, 4-80 months .DISCUSSION AND CONCLUSION: Survival was not significantly influenced by age, gender, extent of resection, tumor size, histology and time interval between surgery and radiotherapy. Statistically significant good prognostic factors for OS was Karnofsky Performance Status KPS > 70 p < 0.001 .

Keywords

Low-grade gliomas, Radiotherapy, Prognostic factors, Overall survival

Yetişkin Düşük Dereceli Gliomlarda Sağkalım ve Prognostik Faktörler

Abstract

GİRİŞ ve AMAÇ: Pilositik olmayan düşük dereceli gliomlarda sağkalım değerlendirmek.YÖNTEM ve GEREÇLER: 2003-2007 yılları arasında Ankara Onkoloji Eğitim ve Araştırma Hastanesinde AOH Düşük Dereceli Glial Tümör tanısıyla tedavi edilen 70 erişkin hasta geriye dönük olarak incelendi. Genel Sağkalım GSK tahminleri Kaplan Meier ile yapıldı.BULGULAR: Ortanca yaş 37.5 aralık; 20-73 ve erkek çoğunlukdaydı erkek/kadın: 1.26 . Ortanca takip süresi 39 aydı aralık; 4-79 . Cerrahi sonucu hastaların %54'ünün saf astrositom, %21'inin oligodendrogliom, %10'unun ise oligoastrositom olduğu belirlendi. Hastaların 44'üne %63 subtotal rezeksiyon STR , 19'una %27 gross total rezeksiyon GTR ve 7'sine %10 biopsi uygulandı. Başvuru şikayeti sıklık sırasıyla başağrısı, nöbet ve motor bozukluktu. Cerrahi ile radyoterapi arasındaki ortanca süre 7 hafta olup, 3 hafta ile 78 hafta arasında değişmekteydi. Ortanca GSK 71 ay aralık, 4-80 ay olarak bulundu.TARTIŞMA ve SONUÇ: Sağkalım; yaş, cinsiyet, tümör boyutu, histolojik tip ve cerrahi sonrası radyoterapi başlama zamanından istatistiki olarak anlamlı derecede etkilenmemiştir. Karnofsky Performans skorunun KPS 70'in üstünde olması istatistiksel olarak anlamlı iyi prognostik faktördür p < 0.001 .

Keywords

Düşük dereceli gliomlar, Radyoterapi, Prognostik Faktörler, Genel Sağkalım

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