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The risk factors associated with severe wheeze episode in preschool children

Year 2015, Volume: 4 Issue: 1, 1 - 5, 01.01.2015
https://doi.org/10.5505/abantmedj.2015.80775

Abstract

OBJECTIVE: To determine the risk factors which associated with severe wheeze episode in preschool childrenMETHODS: Between January 2013 and June 2013, the files of the patients, who were seen as severe wheeze episode and under 6 years old at the time of application, were analyzed retrospectively in the pediatric allergy and pediatric emergency department of Inonü University Turgut Ozal Medical CenterRESULTS: During the six month period, 70 children applied to two clinics pediatric allergy and pediatric emergency due to severe wheeze episode. Seventy-two children who applied with mild wheeze episode were included in the study to compare with severe wheeze episode. Forty-nine patients 68.1% who were diagnosed with severe wheeze episode were male and the median age was 30 6-60 months. The median age of first wheeze episode was 6 1-60 months, median episode of wheeze number in the previous year was 5 1-10 and median episode of wheeze required systemic steroid in the previous year was 2 1-10 . Modified Asthma Predictive Index was positive in 27 patients 38.1% and wheeze was the multiple-trigger phenotype in 29 patients 41.1% . Severe wheeze episode was more in male gender p=0.004 and in children who exposure to passive smoking p=0.011 . Also, frequency of wheeze episode p=0.029 and required systemic steroid p=0.001 in previous year were more in the patients with severe wheeze episodeCONCLUSION: Severe wheeze episode were seen more in the patient who were male gender, exposure to passive smoking, have frequent wheeze episode and require systemic steroid in previous year. Therefore detailed previous year history of wheeze should be questioned in the patient who have wheeze and exposure of passive smoking should be prevented

References

  • Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995;332:133-138.
  • Brand PL, Baraldi E, Bisgaard H, Boner AL, Castro- Rodriguez JA, Custovic A. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008;32:1096-1110.
  • Kappelle L, Brand PL. Severe episodic viral whee- ze in preschool children: High risk of asthma at age 5-10 years. Eur J Pediatr 2012;171:947-954. 4. (GINA) 2011. Available
  • from: http://www.ginasthma.org
  • Kotaniemi-Syrjanen A, Pelkonen AS, Malmström K, Malmberg LP, Makela MJ. Symptom-based classi- fication of wheeze: how does it work in infants? J Allergy Clin Immunol 2011;128:1111-1112.
  • Guilbert TW, Morgan WJ, Zeiger RS, Bacharier LB, Boehmer SJ, Krawiec M, Larsen G, Lemanske RF, Liu A, Mauger DT, Sorkness C, Szefler SJ, Strunk RC, Taussig LM, Martinez FD. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004;114:1282-1287.
  • Guler N, Kirerleri E, Ones U, et al. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol 2004;114:254-9.
  • Alper Z, Sapan N, Ercan I, Canitez Y, Bilgel N. Risk factors for wheezing in primary school children in Bursa, Turkey. Am J Rhinol 2006;20:53-63.
  • Kalyoncu AF, Demir AU, Ozcakar B, Bozkurt B, Artvinli M. Asthma and allergy in Turkish university students: Two cross-sectional surveys 5 years apart otel. Allergol Immunopathol (Madr) 2001;29:264- 271.
  • Selcuk ZT, Caglar T, Enunlu T, Topal T. The preva- lence of allergic diseases in primary school children in Edirne, Turkey. Clin Exp Allergy 1997;27:262-269. 11. Dezateux C, Stocks J, Dundas I, Fletcher ME. Impaired airway function and wheezing in infancy: the influence of maternal smoking and a genetic predisposition to asthma. Am J Respir Crit Care Med 1999;159:403-410.
  • Castro-Rodriguez JA. The Asthma Predictive Index: a very useful tool for predicting asthma in young children. J Allergy Clin Immunol 2010;126:212-216.
  • Bacharier LB, Phillips BR, Bloomberg GR, Zeiger RS, Paul IM, Krawiec M, Guilbert T, Chinchilli VM, Strunk RC. Childhood Asthma Research and Educa- tion Network, National Heart, Lung, and Blood Insti- tute. Severe intermittent wheezing in preschool children: a distinct phenotype. J Allergy Clin Immu- nol 2007;119:604-610.
  • Castro-Rodríguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk ofasthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000;162(4 Pt 1):1403- 1406.
  • Topal E, Bakirtas A, Yilmaz O, Ertoy IHK, Arga M, Demirsoy M, Turktas I. Short-term follow-up of episodic wheeze and predictive factors for persis tent wheeze. Allergy Asthma Proc 2013;34:42-46.

Okul öncesi dönemde ağır hışıltı atağı ile ilişkili risk faktörleri

Year 2015, Volume: 4 Issue: 1, 1 - 5, 01.01.2015
https://doi.org/10.5505/abantmedj.2015.80775

Abstract

AMAÇ: Okul öncesi yaş grubunda ağır hışıltı atağı ile ilişkili risk faktörlerini belirlemektir. YÖNTEMLER: Ocak 2013 ile Haziran 2013 tarihleri arasında İnönü Üniversitesi Turgut Özal Tıp Merkezi Çocuk Alerji ve Astım polikliniği ile Çocuk Acil polikliniğine, tekrarlayan ağır hışıltı atağı ile başvuran altı yaşından küçük hastaların dosyaları geriye dönük olarak incelendi. BULGULAR: Altı aylık sürede her iki polikliniğe çocuk alerji ve çocuk acil 70 çocuk ağır hışıltı atağı ile başvurmuştu. Çalışmaya, karşılaştırma yapabilmek için aynı yaşta hafif hışıltı atağı ile başvuran 72 çocuk hasta da dahil edildi. Ağır hışıltı atak tanısı konulan olguların 49 %68,1 ’u erkek idi ve ortanca yaşı 30 ay 6-60 idi. Hastaların ilk geçirdikleri atak yaşının ortancası 6 ay 1-60 , son bir yıl içerisindeki atak sayısının ortancası 5 1-10 ve son bir yılda sistemik steroid gerektiren atak sayısının ortancası 2 1-10 idi. Modifiye astım prediktif indeks hastaların 27 %38,1 ’sinde pozitifti ve 29 hastada %41,4 hışıltı çoklu tetiklenen hışıltı fenotipindeydi. Ağır hışıltı atağı erkek cinsiyette p=0,004 ve pasif sigara maruziyeti olan çocuklarda p=0,011 daha fazlaydı. Ayrıca son 1 yılda atak sıklığı p=0,029 ve sistemik steroid gerektiren atak sayısı da p=0,001 ağır hışıltı atağı ile başvuran hastalarda daha fazlaydı.SONUÇ: Ağır hışıltı atağı erkek cinsiyette, pasif sigara maruziyeti olan çocuklarda, son bir yılda hışıltı atakları sık olan ve sistemik steroid gerektiren hastalarda daha fazla görülmektedir. Bu nedenle hışıltısı olan çocukların son 1 yıldaki hışıltı öyküleri detaylı bir şekilde sorgulanmalı ve sigara maruziyeti önlenmelidir.

References

  • Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995;332:133-138.
  • Brand PL, Baraldi E, Bisgaard H, Boner AL, Castro- Rodriguez JA, Custovic A. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J 2008;32:1096-1110.
  • Kappelle L, Brand PL. Severe episodic viral whee- ze in preschool children: High risk of asthma at age 5-10 years. Eur J Pediatr 2012;171:947-954. 4. (GINA) 2011. Available
  • from: http://www.ginasthma.org
  • Kotaniemi-Syrjanen A, Pelkonen AS, Malmström K, Malmberg LP, Makela MJ. Symptom-based classi- fication of wheeze: how does it work in infants? J Allergy Clin Immunol 2011;128:1111-1112.
  • Guilbert TW, Morgan WJ, Zeiger RS, Bacharier LB, Boehmer SJ, Krawiec M, Larsen G, Lemanske RF, Liu A, Mauger DT, Sorkness C, Szefler SJ, Strunk RC, Taussig LM, Martinez FD. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004;114:1282-1287.
  • Guler N, Kirerleri E, Ones U, et al. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol 2004;114:254-9.
  • Alper Z, Sapan N, Ercan I, Canitez Y, Bilgel N. Risk factors for wheezing in primary school children in Bursa, Turkey. Am J Rhinol 2006;20:53-63.
  • Kalyoncu AF, Demir AU, Ozcakar B, Bozkurt B, Artvinli M. Asthma and allergy in Turkish university students: Two cross-sectional surveys 5 years apart otel. Allergol Immunopathol (Madr) 2001;29:264- 271.
  • Selcuk ZT, Caglar T, Enunlu T, Topal T. The preva- lence of allergic diseases in primary school children in Edirne, Turkey. Clin Exp Allergy 1997;27:262-269. 11. Dezateux C, Stocks J, Dundas I, Fletcher ME. Impaired airway function and wheezing in infancy: the influence of maternal smoking and a genetic predisposition to asthma. Am J Respir Crit Care Med 1999;159:403-410.
  • Castro-Rodriguez JA. The Asthma Predictive Index: a very useful tool for predicting asthma in young children. J Allergy Clin Immunol 2010;126:212-216.
  • Bacharier LB, Phillips BR, Bloomberg GR, Zeiger RS, Paul IM, Krawiec M, Guilbert T, Chinchilli VM, Strunk RC. Childhood Asthma Research and Educa- tion Network, National Heart, Lung, and Blood Insti- tute. Severe intermittent wheezing in preschool children: a distinct phenotype. J Allergy Clin Immu- nol 2007;119:604-610.
  • Castro-Rodríguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk ofasthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000;162(4 Pt 1):1403- 1406.
  • Topal E, Bakirtas A, Yilmaz O, Ertoy IHK, Arga M, Demirsoy M, Turktas I. Short-term follow-up of episodic wheeze and predictive factors for persis tent wheeze. Allergy Asthma Proc 2013;34:42-46.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Erdem Topal This is me

Ferhat Çatal This is me

Mehmet Aslan This is me

Ramazan Özdemir This is me

Ahmet Karadağ This is me

Gülsüm Demirtaş This is me

Elif Şenbaba This is me

Ahmet Kurt This is me

Publication Date January 1, 2015
Published in Issue Year 2015 Volume: 4 Issue: 1

Cite

APA Topal, E., Çatal, F., Aslan, M., Özdemir, R., et al. (2015). Okul öncesi dönemde ağır hışıltı atağı ile ilişkili risk faktörleri. Abant Medical Journal, 4(1), 1-5. https://doi.org/10.5505/abantmedj.2015.80775
AMA Topal E, Çatal F, Aslan M, Özdemir R, Karadağ A, Demirtaş G, Şenbaba E, Kurt A. Okul öncesi dönemde ağır hışıltı atağı ile ilişkili risk faktörleri. Abant Med J. January 2015;4(1):1-5. doi:10.5505/abantmedj.2015.80775
Chicago Topal, Erdem, Ferhat Çatal, Mehmet Aslan, Ramazan Özdemir, Ahmet Karadağ, Gülsüm Demirtaş, Elif Şenbaba, and Ahmet Kurt. “Okul öncesi dönemde ağır hışıltı atağı Ile ilişkili Risk faktörleri”. Abant Medical Journal 4, no. 1 (January 2015): 1-5. https://doi.org/10.5505/abantmedj.2015.80775.
EndNote Topal E, Çatal F, Aslan M, Özdemir R, Karadağ A, Demirtaş G, Şenbaba E, Kurt A (January 1, 2015) Okul öncesi dönemde ağır hışıltı atağı ile ilişkili risk faktörleri. Abant Medical Journal 4 1 1–5.
IEEE E. Topal, F. Çatal, M. Aslan, R. Özdemir, A. Karadağ, G. Demirtaş, E. Şenbaba, and A. Kurt, “Okul öncesi dönemde ağır hışıltı atağı ile ilişkili risk faktörleri”, Abant Med J, vol. 4, no. 1, pp. 1–5, 2015, doi: 10.5505/abantmedj.2015.80775.
ISNAD Topal, Erdem et al. “Okul öncesi dönemde ağır hışıltı atağı Ile ilişkili Risk faktörleri”. Abant Medical Journal 4/1 (January 2015), 1-5. https://doi.org/10.5505/abantmedj.2015.80775.
JAMA Topal E, Çatal F, Aslan M, Özdemir R, Karadağ A, Demirtaş G, Şenbaba E, Kurt A. Okul öncesi dönemde ağır hışıltı atağı ile ilişkili risk faktörleri. Abant Med J. 2015;4:1–5.
MLA Topal, Erdem et al. “Okul öncesi dönemde ağır hışıltı atağı Ile ilişkili Risk faktörleri”. Abant Medical Journal, vol. 4, no. 1, 2015, pp. 1-5, doi:10.5505/abantmedj.2015.80775.
Vancouver Topal E, Çatal F, Aslan M, Özdemir R, Karadağ A, Demirtaş G, Şenbaba E, Kurt A. Okul öncesi dönemde ağır hışıltı atağı ile ilişkili risk faktörleri. Abant Med J. 2015;4(1):1-5.