The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome

Adem Bekler; Gökhan Erbağ; Hacer Şen; Muhammed Turgut; Alper Özkan; Ali Ümit Yener; Tolga Kurt; Emine Gazi

doi:10.5505/abantmedj.2015.48344

The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome

Year 2015, Volume: 4 Issue: 3, 216 - 221, 01.09.2015

Adem Bekler Gökhan Erbağ Hacer Şen Muhammed Turgut Alper Özkan Ali Ümit Yener Tolga Kurt Emine Gazi

https://doi.org/10.5505/abantmedj.2015.48344

Abstract

OBJECTIVE: The prognostic value of the Global Registry of Acute Coronary Events GRACE risk score has been reported in patients with coronary artery diseases CAD . We aimed to compare the GRACE risk score GRS with the Gensini score GS in predicting the extent and severity of CAD in patients with non-ST elevated acute coronary syndrome NSTE-ACS .METHODS: : A total of 154 patients with NSTE-ACS were included in the study. The GRS relevant scores on the indices were calculated on admission using specified variables. The severity of the CAD was evaluated using the GS. The patients were divided into low GRS140 risk groups according to based on the GRS. A spearman correlation analysis was used for the relation between GRS and GS. RESULTS: There were significantly difference, the mean age p

Keywords

Acute coronary syndrome, Gensini score, GRACE risk score

References

1. Simoons ML, GUSTO IV-ACS Investigators. Effect of glycoprotein 2b/3a receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularization: The GUSTO 4-ACS randomised trial. Lancet 2001; 357: 1915– 1924.
2. Boersma E, Pieper KS, Steyerberg EW, Wilcox RG, Chang WC, Lee KL, Akkerhuis KM, Harrington RA, Deckers JW, Armstrong PW, Lincoff AM, Califf RM, Topol EJ, Simoons ML. Predictors of outcome in patients with acute coronary syndromes without persistent STsegment elevation. Results from an international trial of 9461 patients. The PURSUITS Investigators. Circulation 2000; 101: 2557-2567.
3. Sabatine MS, Antman EM. The thrombolysis in myocardial infarction risk score in unstable angina pectoris/non-ST-segment elevation myocardial infarction. J Am Coll Cardiol 2003; 41: 89S–95S.
4. de Araújo Gonçalves P, Ferreira J, Aguiar C, Seabra-Gomes R. TIMI, PURSUIT and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTE-ACS. Eur Heart J 2005; 26: 865–872.
5. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol, 1983; 51: 606.
6. Sinning C, Lillpopp L, Appelbaum S, Ojeda F, Zeller T, Schnabel R, Lubos E, Jagodzinski A, Keller T, Munzel T, Bickel C, Blankenberg S. Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application. Clin Res Cardiol, 2013; 102: 495-503.
7. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise J, Solomon S, Spencer KT, St John Sutton M, Stewart W. Recommendations for chamber quantification. Eur J Echocardiogr 2006; 2: 79– 108.
8. Thygesen K, Alpert J S, White HD, Jaffe AS, Apple FS, Galvani M, on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the redefinition of myocardial infarction. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525–2538.
9. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, Smith SC Jr1, Svetkey LP, Taler SJ, Townsend RR, Wright JT Jr, Narva AS, Ortiz E. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth Joint National Committee (JNC 8). JAMA 2014; 311: 507-520.
10. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011; 34: 62-69.
11. Ndrepepa G, Braun S, Schulz S, Mehilli J, Schömig A, Kastrati A. High sensitivity troponin T level and angiographic severity of coronary artery disease. Am J Cardiol, 2011; 108: 639– 643.
12. Gravning J, Smedsrud MK, Omland T, Eek C, Skulstad H, Aaberge L, Bendz B, Kjekshus J, Mørkrid L, Edvardsen T. Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: prediction of significant coronary lesions and long-term prognosis. Am Heart J, 2013; 165: 716–724.
13. Tang EW, Wong CK, Herbison P. Global registry of acute coronary events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome. Am Heart J 2007; 153: 29- 35.
14. Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, van den Brand M, Van Dyck N, Russell ME, Mohr FW, Serruys PW. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. Eurointervention 2005; 1: 219–227.
15. Wang H, Tang Z, Li X, Hu B, Feng B. Angiographic evaluation of glucose metabolic status on coronary artery lesions in patients with coronary artery disease. 2014 Jul 1. doi: 10.1111/1753-0407.12188. [Epub ahead of print].
16. Bai MF, Gao CY, Yang CK, Wang XP, Liu J, Qi DT, Zhang Y, Hao PY, Li MW. Effects of thyroid dysfunction on the severity of coronary artery lesions and its prognosis. J Cardiol. 2014 Jun 17. pii: S0914-5087(14)00104-X. doi: 10.1016/j.jjcc.2014.03.009. [Epub ahead of print].
17. Cakar MA, Sahinkus S, Aydin E, Vatan MB, Keser N, Akdemir R, Gündüz H. Relation between the GRACE score and severity of atherosclerosis in acute coronary syndrome. J Cardiol. 2014; 63: 24-28.

ST elevasyonu olmayan akut koroner sendrom hastalarında koroner arter hastalığı yaygınlığı ile GRACE risk skoru arasındaki ilişki

Year 2015, Volume: 4 Issue: 3, 216 - 221, 01.09.2015

Adem Bekler Gökhan Erbağ Hacer Şen Muhammed Turgut Alper Özkan Ali Ümit Yener Tolga Kurt Emine Gazi

https://doi.org/10.5505/abantmedj.2015.48344

Abstract

AMAÇ: Akut koroner olayların global kaydı GRACE risk skorunun koroner arter hastalığı KAH hastalarındaki prognostik değeri daha önce gösterilmiştir. Biz burada ST elevasyonu olmayan akut koroner sendrom hastalarında STEO-AKS , KAH varlığı ve yaygınlığı öngörüsünde GRACE risk skoru GRS ile Gensini skorunun GS karşılaştırılmasını amaçladık.YÖNTEMLER: Çalışmaya toplam 154 STEO-AKS hastası alındı. GRS ile ilgili skorlar başvurudaki spesifik değişkenlerle hesaplandı. KAH yaygınlığı GS ile değerlendirildi ve Hastalar GRS' ye göre düşük GRS140 olarak 3 gruba ayrıldı. GRS ve GS arasındaki ilişki için spearman korelasyon analizi uygulandı. BULGULAR: Tüm hastalarda düşük, orta ve yüksek risk gruplarında ortalama yaş p

Keywords

Akut koroner sendrom, Gensini skoru, GRACE risk skoru

References

1. Simoons ML, GUSTO IV-ACS Investigators. Effect of glycoprotein 2b/3a receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularization: The GUSTO 4-ACS randomised trial. Lancet 2001; 357: 1915– 1924.
2. Boersma E, Pieper KS, Steyerberg EW, Wilcox RG, Chang WC, Lee KL, Akkerhuis KM, Harrington RA, Deckers JW, Armstrong PW, Lincoff AM, Califf RM, Topol EJ, Simoons ML. Predictors of outcome in patients with acute coronary syndromes without persistent STsegment elevation. Results from an international trial of 9461 patients. The PURSUITS Investigators. Circulation 2000; 101: 2557-2567.
3. Sabatine MS, Antman EM. The thrombolysis in myocardial infarction risk score in unstable angina pectoris/non-ST-segment elevation myocardial infarction. J Am Coll Cardiol 2003; 41: 89S–95S.
4. de Araújo Gonçalves P, Ferreira J, Aguiar C, Seabra-Gomes R. TIMI, PURSUIT and GRACE risk scores: sustained prognostic value and interaction with revascularization in NSTE-ACS. Eur Heart J 2005; 26: 865–872.
5. Gensini GG. A more meaningful scoring system for determining the severity of coronary heart disease. Am J Cardiol, 1983; 51: 606.
6. Sinning C, Lillpopp L, Appelbaum S, Ojeda F, Zeller T, Schnabel R, Lubos E, Jagodzinski A, Keller T, Munzel T, Bickel C, Blankenberg S. Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application. Clin Res Cardiol, 2013; 102: 495-503.
7. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise J, Solomon S, Spencer KT, St John Sutton M, Stewart W. Recommendations for chamber quantification. Eur J Echocardiogr 2006; 2: 79– 108.
8. Thygesen K, Alpert J S, White HD, Jaffe AS, Apple FS, Galvani M, on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the redefinition of myocardial infarction. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525–2538.
9. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, Smith SC Jr1, Svetkey LP, Taler SJ, Townsend RR, Wright JT Jr, Narva AS, Ortiz E. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth Joint National Committee (JNC 8). JAMA 2014; 311: 507-520.
10. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011; 34: 62-69.
11. Ndrepepa G, Braun S, Schulz S, Mehilli J, Schömig A, Kastrati A. High sensitivity troponin T level and angiographic severity of coronary artery disease. Am J Cardiol, 2011; 108: 639– 643.
12. Gravning J, Smedsrud MK, Omland T, Eek C, Skulstad H, Aaberge L, Bendz B, Kjekshus J, Mørkrid L, Edvardsen T. Sensitive troponin assays and N-terminal pro-B-type natriuretic peptide in acute coronary syndrome: prediction of significant coronary lesions and long-term prognosis. Am Heart J, 2013; 165: 716–724.
13. Tang EW, Wong CK, Herbison P. Global registry of acute coronary events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome. Am Heart J 2007; 153: 29- 35.
14. Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, van den Brand M, Van Dyck N, Russell ME, Mohr FW, Serruys PW. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. Eurointervention 2005; 1: 219–227.
15. Wang H, Tang Z, Li X, Hu B, Feng B. Angiographic evaluation of glucose metabolic status on coronary artery lesions in patients with coronary artery disease. 2014 Jul 1. doi: 10.1111/1753-0407.12188. [Epub ahead of print].
16. Bai MF, Gao CY, Yang CK, Wang XP, Liu J, Qi DT, Zhang Y, Hao PY, Li MW. Effects of thyroid dysfunction on the severity of coronary artery lesions and its prognosis. J Cardiol. 2014 Jun 17. pii: S0914-5087(14)00104-X. doi: 10.1016/j.jjcc.2014.03.009. [Epub ahead of print].
17. Cakar MA, Sahinkus S, Aydin E, Vatan MB, Keser N, Akdemir R, Gündüz H. Relation between the GRACE score and severity of atherosclerosis in acute coronary syndrome. J Cardiol. 2014; 63: 24-28.

There are 17 citations in total.

Details

Primary Language	English
Journal Section	Research Article
Authors	Adem Bekler This is me Gökhan Erbağ This is me Hacer Şen This is me Muhammed Turgut This is me Alper Özkan This is me Ali Ümit Yener This is me Tolga Kurt This is me Emine Gazi This is me
Publication Date	September 1, 2015
Published in Issue	Year 2015 Volume: 4 Issue: 3

Cite

APA	Bekler, A., Erbağ, G., Şen, H., Turgut, M., et al. (2015). The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome. Abant Medical Journal, 4(3), 216-221. https://doi.org/10.5505/abantmedj.2015.48344
AMA	Bekler A, Erbağ G, Şen H, Turgut M, Özkan A, Yener AÜ, Kurt T, Gazi E. The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome. Abant Med J. September 2015;4(3):216-221. doi:10.5505/abantmedj.2015.48344
Chicago	Bekler, Adem, Gökhan Erbağ, Hacer Şen, Muhammed Turgut, Alper Özkan, Ali Ümit Yener, Tolga Kurt, and Emine Gazi. “The Relationship Between the GRACE Risk Score and the Severity of Coronary Artery Disease in Patients With Non-ST Elevated Acute Coronary Syndrome”. Abant Medical Journal 4, no. 3 (September 2015): 216-21. https://doi.org/10.5505/abantmedj.2015.48344.
EndNote	Bekler A, Erbağ G, Şen H, Turgut M, Özkan A, Yener AÜ, Kurt T, Gazi E (September 1, 2015) The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome. Abant Medical Journal 4 3 216–221.
IEEE	A. Bekler, G. Erbağ, H. Şen, M. Turgut, A. Özkan, A. Ü. Yener, T. Kurt, and E. Gazi, “The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome”, Abant Med J, vol. 4, no. 3, pp. 216–221, 2015, doi: 10.5505/abantmedj.2015.48344.
ISNAD	Bekler, Adem et al. “The Relationship Between the GRACE Risk Score and the Severity of Coronary Artery Disease in Patients With Non-ST Elevated Acute Coronary Syndrome”. Abant Medical Journal 4/3 (September 2015), 216-221. https://doi.org/10.5505/abantmedj.2015.48344.
JAMA	Bekler A, Erbağ G, Şen H, Turgut M, Özkan A, Yener AÜ, Kurt T, Gazi E. The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome. Abant Med J. 2015;4:216–221.
MLA	Bekler, Adem et al. “The Relationship Between the GRACE Risk Score and the Severity of Coronary Artery Disease in Patients With Non-ST Elevated Acute Coronary Syndrome”. Abant Medical Journal, vol. 4, no. 3, 2015, pp. 216-21, doi:10.5505/abantmedj.2015.48344.
Vancouver	Bekler A, Erbağ G, Şen H, Turgut M, Özkan A, Yener AÜ, Kurt T, Gazi E. The relationship between the GRACE risk score and the severity of coronary artery disease in patients with non-ST elevated acute coronary syndrome. Abant Med J. 2015;4(3):216-21.