Increased pentraxin-3 level in patients with slow coronary flow

Year 2013, Volume: 2 Issue: 3, 185 - 190, 01.09.2013

Eyüp Büyükkaya Mehmet Fatih Karakaş Mustafa Kurt Esra Karakaş Şule Büyükkaya Adnan Burak Akçay Nihat Şen

https://doi.org/10.5505/abantmedj.2013.43153

Abstract

OBJECTIVE: Slow coronary flow SCF is defined as late opacification in the epicardial coronary artery without significant stenosis on the coronary angiographic images. The association between SCF and inflammation and inflammatory markers such as high sensitivity-C reactive protein hs-CRP is well known. Pentraxin-3 PTX-3 , a new acute phase reactant, is a member of pentraxine family like hs-CRP. We investigated the association between PTX-3 and hs-CRP in patients with SCF.METHODS: The study included 25 patients with SCF and 26 patients with coronary artery disease CAD whose diagnoses were made by coronary angiography. The control group consisted of 24 healthy subjects admitted cardiology outpatient clinic without any sign of ischemia. From the all study population PTX-3 and hs-CRP levels were measured.RESULTS: The SCF group had significantly increased PTX-3 and hs-CRP levels than the control group 0.52 ± 0.2 ng/ml vs 0.20 ±0.08 ng/ml, p< 0.001; 1.1±0.4 mg/dl vs 0.6±0.5 mg/dl, p< 0.001, respectively . However there were no differences in levels of PTX-3 and hs-CRP between the SCF and the CAD groups 0.52 ± 0.2 ng/ml vs 0.58 ± 0.18 ng/ml, p: 0.24; 1.1 ± 0.4 mg/dl vs 1.1 ± 0.6 mg/dl; p: 0.32, respectively . Correlation analysis revealed a positive correlation between serum PTX-3 levels and hs-CRP levels r=0.34, p: 0.003 .CONCLUSION: PTX-3, a novel inflammatory marker, is elevated in patients with SCF and may be reflecting the inflammatory status in patients with SCF.

Keywords

Slow coronary flow, Pentraxin-3, hs-CRP

Koroner yavaş akım olan hastalarda pentraksin-3 düzeyi artmıştır

Abstract

AMAÇ: Koroner yavaş akım YKA , anjiyografisinde normal koroner arterlere sahip olup opak maddenin koronerlerin distaline geç ulaşması ile karakterizedir. YKA’ın inflamasyon ve yüksek duyarlıklı C reaktif protein hs-CRP gibi inflamatuvar belirteçler ile ilişkisi bilinmektedir. Pentraksin-3 PTX-3 , yeni bir akut faz reaktanı olup CRP gibi pentraksin ailesinin bir üyesidir. Biz bu çalışmada YKA hastalarında PTX-3 düzeyini araştırdık.YÖNTEMLER: Çalışmaya YKA saptanan 25 hasta ve koroner arter hastalığı KAH olan 26 hasta alındı. Yavaş koroner akım ve KAH tanısı koroner anjiyografi ile konuldu. Kardiyoloji polikliniğine başvurmuş iskemik bulguların gözlenmediği 24 sağlıklı birey kontrol grubu olarak alındı. Tüm grubun PTX-3 ve hs-CRP çalışıldıBULGULAR: KYA grubundaki hastaların PTX-3 ve hs-CRP seviyesi kontrol grubuna göre daha yüksekti sırasıyla 0.52 ± 0.2 ng/ml ve 0.20 ±0.08 ng/ml, p< 0.001; 1.1±0.4 mg/dl ve 0.6±0.5 mg/dl, p< 0.001 . Ancak KYA grubu ile KAH grubu arasında serum PTX-3 ile hs-CRP seviyesinde fark bulunmadı sırasıyla 0.52 ± 0.2 ng/ml ve 0.58 ± 0.18 ng/ml, p: 0.24; 1.1 ± 0.4 mg/dl ve 1.1 ± 0.6 mg/dl; p: 0.32 . Korelasyon analizi sonucu serum PTX-3 ve hs-CRP seviyeleri birbirleriyle ilişkili bulundu. Rho=0.34, p: 0.003 .SONUÇ: PTX-3, yeni bir inflamatuvar marker olup YKA olan hastalarda yükselmiştir ve bu hastalarda inflamatuvar durumu yansıtmada bir belirteçtir.

Keywords

Koroner yavaş akım, hs-CRP, inflamasyon, Pentraksin-3

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