Uterine Carcinosarcoma Presented With Asymptomatic Vaginal Discharge; A Rare Case

Year 2013, Volume: 2 Issue: 3, 235 - 237, 01.09.2013

Serap Aynur Simavlı Emel Bilici

https://doi.org/10.5505/abantmedj.2013.55264

Abstract

Uterine carcinosarcoma also known as malignant mixed mullerian tumor MMMT of uterus is very rare but highly aggressive neoplasm that usually arises in postmenopausal age group. Carcinosarcoma is no longer classified uterine sarcomas subgroup. Today it is accepted as a metaplastic carcinoma. In this case we present a 71 year-old patient with 1-month history of pale vaginal discharge. Transvaginal ultrasonography revealed endometrial thickness of 28mm in polypoid appeareance. and myometrial heterogeneity. Endometrial curettage was performed. Hystopathologic diagnosis is carcinosarcoma. Here in we discussed an uterine carcinosarcoma of a postmenapausal woman who is represented with asymptomatic vaginal discharge according to the current literature.

Keywords

Uterine carcinosarcoma. postmenopausal, vaginal discharge

Asemptomatik Vajinal Akıntı İle Belirlenen Uterin Karsinosarkom; Nadir Bir Olgu

Abstract

Karsinosarkom diğer adı ile malign mikst müllerian tümör MMMT , nadir görülen, agresif seyirli, genelde postmenopozal yaşlarda oluşan bir neoplazidir. Karsinosarkom daha önceleri uterin sarkomların alt grubu olarak sınıflandırılmasına rağmen günümüzde metaplastik karsinom olarak kabul edilmektedir. 71 yaşındaki hasta 1 aydır olan şeffaf renkli akıntı şikayeti ile polikliniğe başvurdu. Yapılan transvajinal ultrasonografide endometriyum 28 mm, polipoid görünümde ve miyometriyum heterojen olarak izlendi. Hastaya probe kürataj yapıldı. Histopatoloji sonucu karsinosarkom olarak rapor edildi. Bu olgu sunumunda postmenopozal asemptomatik vajinal akıntı ile başvuran hastadaki uterin karsinosarkom vakası güncel litaratür eşliğinde tartışılmıştır.

Keywords

Uterin karsinosarkom, postmenopozal, vajinal akıntı

References

• Brooks SE, Zhan M, Cote T, Baquet CR: Surveillance, epi- demiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol 2004;93:204-208.
• Tse KY, Crawford R, Ngan HY: Staging of uterine sarco- mas. Best Pract Res Clin Obstet Gynaecol 2011;25:733-749. 3. Prat J: Figo staging for uterine sarcomas. Int J Gynaecol Obstet 2009;104:177-178.
• Schweizer W, Demopoulos R, Beller U, Dubin N: Prognos- tic factors for malignant mixed mullerian tumors of the uterus. Int J Gynecol Pathol 1990;9:129-136.
• Harlow BL, Weiss NS, Lofton S: The epidemiology of sar- comas of the uterus. J Natl Cancer Inst 1986;76:399-402.
• McCluggage WG: Uterine carcinosarcomas (malignant mixed mullerian tumors) are metaplastic carcinomas. Int J Gynecol Cancer 2002;12:687-690.
• Ferrandina G, Zannoni GF, Martinelli E, Vellone V, Prisco MG, Scambia G: Endometrial carcinoma recurring as carci- nosarcoma: Report of two cases. Pathol Res Pract 2007;203:677-681.
• Buza N, Tavassoli FA: Comparative analysis of p16 and p53 expression in uterine malignant mixed mullerian tu- mors. Int J Gynecol Pathol 2009;28:514-521.
• Mikami Y, Hata S, Kiyokawa T, Manabe T: Expression of cd10 in malignant mullerian mixed tumors and adenosar- comas: An immunohistochemical study. Mod Pathol 2002;15:923-930.
• Gadducci A, Cosio S, Romanini A, Genazzani AR. The management of patients with uterine sarcoma: a debated clinical challenge. Crit Rev Oncol Hematol. 2008;65: 129-42.