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Metabolic syndrome and Gender Difference: Tissue Doppler Study

Year 2012, Volume: 1 Issue: 2, 39 - 44, 01.05.2012
https://doi.org/10.5505/abantmedj.2012.35744

Abstract

OBJECTIVE: Metabolic syndrome MS is a cluster of cardiovascular risk factors. Gender difference has different effects on cardiac functions in MS and this has been thought to be decisive in terms of interference. In this study, we aimed to investigate the effect gender differences MS patients with tissue Doppler echocardiography. METHODS: The study population consisted of 83 females and 87 males with the diagnosis of MS. All the study population underwent a detailed echocardiography with tissue Doppler parameters of systolic myocardial velocity Sm , early diastolic velocity Em and late diastolic velocity Am were measured from septal, lateral, and right ventricular annulus. Myocardial performance index MPI was calculated by dividing the sum of isovolumetric relaxation and isovolumetric contractine times by ejection time. RESULTS: While there were no significant differences in early and late diastolic velocities, septal, lateral Sm measurements and septal MPI were significantly higher in men than in women p values: 0,007, 0,001 and 0,027 respectively . Right ventricle and lateral MPI were comparable between study groups. Besides septal and lateral ejection times were significantly higher in men when compared to women p values: 0,016 and 0,012 respectively . CONCLUSION: Cardiac functions in patients with metabolic syndrome differ between the sexes. The different effect of MS on sexes is important in the development of patient-oriented treatment strategies in terms of improving the treatment of coronary artery disease and risk factors.

References

  • Dursunoğlu D, Evrengül H, Tanriverdi H, Kuru O, Gür S, Kaftan A, Kiliç M. Do female patients with metabolic syndrome have masked left ventricular dysfunction? Anadolu Kardiyol Derg, 2005; 5: p. 283-8.
  • Ford ES., WH. Giles, and WH. Dietz. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA, 2002. 287: p. 356-9.
  • Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kum- pusalo E, Tuomilehto J, Salonen JT. The metabolic synd- rome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002:4;288:2709-16.
  • Onat A, Ceyhan K, Başar O, Erer B, Toprak S, Sansoy V. Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels--a prospective and cross-sectional evaluation. Atherosclerosis, 2002. 165: p. 285-92.
  • Ozsahin AK, Gokcel A, Sezgin N, Akbaba M, Guvener N, Ozisik L, Karademir BM. Prevalence of the metabolic syndrome in a Turkish adult population. Diabetes Nutr Metab, 2004. 17: p. 230-4.
  • Reaven GM. Banting lecture 1988. Role of insulin resis- tance in human disease. Diabetes, 1988. 37: p. 1595- 607.
  • Chinali M, Devereux RB, Howard BV, Roman MJ, Bella JN, Liu JE, Resnick HE, Lee ET, Best LG, de Simone G. Comparison of cardiac structure and function in Ameri- can Indians with and without the metabolic syndrome (the Strong Heart Study). Am J Cardiol, 2004. 93: p. 40- 4.
  • Murphy JG., MA. Lloyd, and Mayo Clinic. Mayo Clinic cardiology: concise textbook. 3rd ed. 2007, Rochester, MN: Mayo Clinic Scientific Press: Informa Healthcare USA. XXIII, 1580 p.
  • Eric J. Topol, Robert M. Califf, Jeffrey Isner, Eric N. Prys- towsky, Judith Swain, James Thomas, Paul Thompson, James B. Young. Textbook of cardiovascular medicine. 2nd ed. 2002, Philadelphia: Lippincott Williams & Wil- kins. XXI, 2210 p.
  • Knopp RH., X. Zhu, and B. Bonet. Effects of estrogens on lipoprotein metabolism and cardiovascular disease in women. Atherosclerosis, 1994. 110 Suppl: p. S83-91.
  • Knopp R, Poirier P. Exaggerated lipoprotein abnormali- ties in diabetic women as compared with diabetic men:possible significan ce fo atherosclerosis. cardiovascular health and disease in women, 1993: p. 131-138
  • Hokanson JE. and MA. Austin. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta- analysis of population-based prospective studies. J Car- diovasc Risk, 1996. 3: p. 213-9.
  • Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Cas- telli WP, Knoke JD, Jacobs DR Jr, Bangdiwala S, Tyroler HA. High-density lipoprotein cholesterol and cardiovas- cular disease. Four prospective American studies. Circu- lation, 1989. 79: p. 8-15.
  • Schillaci G, Pirro M, Pucci G, Mannarino MR, Gemelli F, Siepi D, Vaudo G, Mannarino E.
  • Different impact of the metabolic syndrome on left ventricular structure and function in hypertensive men and women. Hypertension, 2006. 47: p. 881-6.
  • Hunt KJ, Resendez RG, Williams K, Haffner SM, Stern MP. San Antonio Heart Study., National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardio- vascular mortality in the San Antonio Heart Study. Circu- lation, 2004. 110: p. 1251-7.
  • Turhan H, Yasar AS, Yagmur J, Kurtoglu E, Yetkin E. The impact of metabolic syndrome on left ventricular func- tion: evaluated by using the index of myocardial per- formance. Int J Cardiol, 2009. 132: p. 382-6.
  • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 2002. 106: p. 3143-421.
  • Griffin Brian P; Topol Eric J. Manual of cardiovascular medicine. 3rd ed. 2009, Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. xvii, 1015 p.
  • Chinali M, de Simone G, Roman MJ, Best LG, Lee ET, Russell M, Howard BV, Devereux RB. Cardiac markers of preclinical disease in adolescents with the metabolic syndrome. JACC. 2008; 52:932-8
  • Schillaci G, Pirro M, Pucci G, Mannarino MR, Gemelli F, Siepi D, Vaudo G, Mannarino E. Different impact of the metabolic syndrome on left ventricular structure and function in hypertention men and women. Hyperten- sion. 2006;47:881-886.

Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması

Year 2012, Volume: 1 Issue: 2, 39 - 44, 01.05.2012
https://doi.org/10.5505/abantmedj.2012.35744

Abstract

AMAÇ: Metabolik sendrom MS kardiyak fonksiyonlar üzerine zararlı etkileri olan risk faktörleri kümesidir. Cinsiyet farkının metabolik sendromun kardiyak fonksiyonlar üzerinde farklı etkileri olduğu ve daha fazla etkilenme açısından belirleyici olduğu düşünülmektedir. Biz bu çalışmamızda MS hastalarında cinsiyet farkının kardiyak fonksiyonlar üzerine olan etkisini doku Doppler tekniği kullanarak araştırmayı amaçladıkYÖNTEMLER: Çalışmaya MS tanısı konan 83 kadın ve 87 erkek hasta alınmıştır. Bu hastalara ayrıntılı transtorasik ekokardiyografi yapılarak doku Doppler parametreleri olan sistolik miyokardiyal hız Sm , erken diyastolik hız Em ve geç diyastolik hız Am , septal, lateral ve sağ ventrikül bölgelerinden ölçüldü. Miyokard performans indeksi MPİ isovolümetrik kontraksiyon ve relaksasyon zamanlarının toplamının aortik ejeksiyon zamanına oranı olarak hesaplandı.BULGULAR: Erken ve geç diyastolik hızlarda fark saptanmazken septal, lateral Sm değerleri ve septal MPI erkeklerde kadınlara göre anlamlı şekilde yüksek saptandı p değeri sırasıyla 0,007, 0,001 ve 0,027 Sağ ventrikül ve lateral MPI değerlerinde fark saptanmadı. Ayrıca septal ve lateral ejeksiyon zamanı değerleri erkeklerde anlamlı şekilde yüksek saptandı p değeri sırasıyla 0,016 ve 0,012 . SONUÇ: Metabolik sendromlu hastalarda kardiyak fonksiyonlar cinsiyetler arasında farklılık göstermektedir. Metabolik sendromun farklı cinsiyetlerde etkisinin farklı olması, birey odaklı tedavi stratejileri geliştirmek açısından değerlendirildiğinde koroner arter hastalığı ve risk faktörlerinin tedavisinde farklı yaklaşımlar geliştirilmesinde önemlidir.

References

  • Dursunoğlu D, Evrengül H, Tanriverdi H, Kuru O, Gür S, Kaftan A, Kiliç M. Do female patients with metabolic syndrome have masked left ventricular dysfunction? Anadolu Kardiyol Derg, 2005; 5: p. 283-8.
  • Ford ES., WH. Giles, and WH. Dietz. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA, 2002. 287: p. 356-9.
  • Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kum- pusalo E, Tuomilehto J, Salonen JT. The metabolic synd- rome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002:4;288:2709-16.
  • Onat A, Ceyhan K, Başar O, Erer B, Toprak S, Sansoy V. Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels--a prospective and cross-sectional evaluation. Atherosclerosis, 2002. 165: p. 285-92.
  • Ozsahin AK, Gokcel A, Sezgin N, Akbaba M, Guvener N, Ozisik L, Karademir BM. Prevalence of the metabolic syndrome in a Turkish adult population. Diabetes Nutr Metab, 2004. 17: p. 230-4.
  • Reaven GM. Banting lecture 1988. Role of insulin resis- tance in human disease. Diabetes, 1988. 37: p. 1595- 607.
  • Chinali M, Devereux RB, Howard BV, Roman MJ, Bella JN, Liu JE, Resnick HE, Lee ET, Best LG, de Simone G. Comparison of cardiac structure and function in Ameri- can Indians with and without the metabolic syndrome (the Strong Heart Study). Am J Cardiol, 2004. 93: p. 40- 4.
  • Murphy JG., MA. Lloyd, and Mayo Clinic. Mayo Clinic cardiology: concise textbook. 3rd ed. 2007, Rochester, MN: Mayo Clinic Scientific Press: Informa Healthcare USA. XXIII, 1580 p.
  • Eric J. Topol, Robert M. Califf, Jeffrey Isner, Eric N. Prys- towsky, Judith Swain, James Thomas, Paul Thompson, James B. Young. Textbook of cardiovascular medicine. 2nd ed. 2002, Philadelphia: Lippincott Williams & Wil- kins. XXI, 2210 p.
  • Knopp RH., X. Zhu, and B. Bonet. Effects of estrogens on lipoprotein metabolism and cardiovascular disease in women. Atherosclerosis, 1994. 110 Suppl: p. S83-91.
  • Knopp R, Poirier P. Exaggerated lipoprotein abnormali- ties in diabetic women as compared with diabetic men:possible significan ce fo atherosclerosis. cardiovascular health and disease in women, 1993: p. 131-138
  • Hokanson JE. and MA. Austin. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta- analysis of population-based prospective studies. J Car- diovasc Risk, 1996. 3: p. 213-9.
  • Gordon DJ, Probstfield JL, Garrison RJ, Neaton JD, Cas- telli WP, Knoke JD, Jacobs DR Jr, Bangdiwala S, Tyroler HA. High-density lipoprotein cholesterol and cardiovas- cular disease. Four prospective American studies. Circu- lation, 1989. 79: p. 8-15.
  • Schillaci G, Pirro M, Pucci G, Mannarino MR, Gemelli F, Siepi D, Vaudo G, Mannarino E.
  • Different impact of the metabolic syndrome on left ventricular structure and function in hypertensive men and women. Hypertension, 2006. 47: p. 881-6.
  • Hunt KJ, Resendez RG, Williams K, Haffner SM, Stern MP. San Antonio Heart Study., National Cholesterol Education Program versus World Health Organization metabolic syndrome in relation to all-cause and cardio- vascular mortality in the San Antonio Heart Study. Circu- lation, 2004. 110: p. 1251-7.
  • Turhan H, Yasar AS, Yagmur J, Kurtoglu E, Yetkin E. The impact of metabolic syndrome on left ventricular func- tion: evaluated by using the index of myocardial per- formance. Int J Cardiol, 2009. 132: p. 382-6.
  • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 2002. 106: p. 3143-421.
  • Griffin Brian P; Topol Eric J. Manual of cardiovascular medicine. 3rd ed. 2009, Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins. xvii, 1015 p.
  • Chinali M, de Simone G, Roman MJ, Best LG, Lee ET, Russell M, Howard BV, Devereux RB. Cardiac markers of preclinical disease in adolescents with the metabolic syndrome. JACC. 2008; 52:932-8
  • Schillaci G, Pirro M, Pucci G, Mannarino MR, Gemelli F, Siepi D, Vaudo G, Mannarino E. Different impact of the metabolic syndrome on left ventricular structure and function in hypertention men and women. Hyperten- sion. 2006;47:881-886.
There are 21 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Göktürk İpek This is me

Emine Bilen This is me

Mustafa Kurt This is me

Mehmet Fatih Karakaş This is me

Uğur Arslantaş This is me

İsa Öner Yüksel This is me

Ayşe Saatci Yaşar This is me

Mehmet Bilge This is me

Publication Date May 1, 2012
Published in Issue Year 2012 Volume: 1 Issue: 2

Cite

APA İpek, G., Bilen, E., Kurt, M., Karakaş, M. F., et al. (2012). Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması. Abant Medical Journal, 1(2), 39-44. https://doi.org/10.5505/abantmedj.2012.35744
AMA İpek G, Bilen E, Kurt M, Karakaş MF, Arslantaş U, Yüksel İÖ, Yaşar AS, Bilge M. Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması. Abant Med J. May 2012;1(2):39-44. doi:10.5505/abantmedj.2012.35744
Chicago İpek, Göktürk, Emine Bilen, Mustafa Kurt, Mehmet Fatih Karakaş, Uğur Arslantaş, İsa Öner Yüksel, Ayşe Saatci Yaşar, and Mehmet Bilge. “Metabolik Sendrom Ve Cinsiyet: Doku Doppler Çalışması”. Abant Medical Journal 1, no. 2 (May 2012): 39-44. https://doi.org/10.5505/abantmedj.2012.35744.
EndNote İpek G, Bilen E, Kurt M, Karakaş MF, Arslantaş U, Yüksel İÖ, Yaşar AS, Bilge M (May 1, 2012) Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması. Abant Medical Journal 1 2 39–44.
IEEE G. İpek, E. Bilen, M. Kurt, M. F. Karakaş, U. Arslantaş, İ. Ö. Yüksel, A. S. Yaşar, and M. Bilge, “Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması”, Abant Med J, vol. 1, no. 2, pp. 39–44, 2012, doi: 10.5505/abantmedj.2012.35744.
ISNAD İpek, Göktürk et al. “Metabolik Sendrom Ve Cinsiyet: Doku Doppler Çalışması”. Abant Medical Journal 1/2 (May 2012), 39-44. https://doi.org/10.5505/abantmedj.2012.35744.
JAMA İpek G, Bilen E, Kurt M, Karakaş MF, Arslantaş U, Yüksel İÖ, Yaşar AS, Bilge M. Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması. Abant Med J. 2012;1:39–44.
MLA İpek, Göktürk et al. “Metabolik Sendrom Ve Cinsiyet: Doku Doppler Çalışması”. Abant Medical Journal, vol. 1, no. 2, 2012, pp. 39-44, doi:10.5505/abantmedj.2012.35744.
Vancouver İpek G, Bilen E, Kurt M, Karakaş MF, Arslantaş U, Yüksel İÖ, Yaşar AS, Bilge M. Metabolik Sendrom ve Cinsiyet: Doku Doppler Çalışması. Abant Med J. 2012;1(2):39-44.