Submakuler Hemoraji Olgusunda İntravitreal Aflibersept

Emine Çakar; Saadet Gültekin Irgat; Fatih Özcura

doi:10.47493/abantmedj.853734

Case Report

Submakuler Hemoraji Olgusunda İntravitreal Aflibersept

Year 2021, Volume: 10 Issue: 2, 295 - 299, 31.08.2021

Emine Çakar , Saadet Gültekin Irgat Fatih Özcura

Abstract

Ellisekiz yaşında erkek olgu, sol gözde 1 aydır devam eden görme azalması şikayeti ile başvurdu. oftalmolojik muayenesinde görme keskinliği sağ gözde 0,8, sol gözde 0,2 idi. Göz içi basınçları (GİB) sırasıyla 17 ve 13 mmHg ölçüldü. Biyomikroskopide sağ göz evre 2 nükleer skleroz, sol göz psödofakikti. Fundus muayenesinde sağ doğal, sol makulada yaklaşık 8-9 optik disk çapında subretinal hemoraji, üst temporal arkuat hizasında hiperpigmente lezyon saptandı. Fundus Fluoresein anjiografide(FFA) sol gözde yaklaşık 8-9 optik disk çapında koroid blokajına neden olan geniş bir hipofloresan alan ve üst temporal arkuat hizasında geç dönemde belirginleşen hiperfloresan alan mevcuttu. Optik koherens tomografide (OKT) merkezi makula kalınlığı sağ gözde 243 µm, sol gözde 641 µm idi. Olgunun muayene bulguları ve tetkikler sonucunda submakular hemoraji tanısı konuldu. Olgumuza tedavi seçenekleri arasından intravitreal aflibercept enjeksiyonu uygulandı. Uygulanan dört doz intravitreal aflibersept sonrasında olgunun görme keskinliğinin 0,6’ya yükseldiği, fundus muayenesinde subretinal hemorajinin kaybolduğu ve merkezi makula kalınlığının 388 µm’ye gerilediği görüldü. Submakuler hemoraji olgularında intravitreal aflibercept enjeksiyonunun, primer tedavi olarak düşünülebileceğine dikkat çekmek istedik.

Keywords

aflibercept, submakuler hemoraji, subretinal hemoraji

References

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2. Paradee Kunavisarut, MD, Tipparut Thithuan, MD, Direk Patikulsila, MD, et al. Submacular Hemorrhage: Visual Outcomes and Prognostic Factors. Asia Pac J Ophthalmol (Phila). 2018 Mar-Apr;7(2):109-13.
3. Mehmet Çakır, Ziya Kapran, Tuğrul Atlan et al. Subretinal t-PA and Pneumatic Displacement in Submacular Hemorrhage. Ret-Vit. 2005;13:Özel Sayı 19-21
4. Avery RL, Fekrat S, Hawkins BS, Bressler NM. Natural histury of subfoveal subretinal hemorrhage in age-related macular degeneration. Retina 1996;16:183-9.
5. Glatt H, Machemer R.: Experimental subretinal hemorrhage in rabbits. Am J Ophthalmol 1996;122:484-93.
6. Tennant MT, Borillo JL, Regillo CD. Management of submacular hemorrhage. Ophthalmol Clin Nort Am. 2002;15:445-52.
7. Krepler K, Kruger A, Tittl M, Stur M, Wedrich A. Intravitreal injection of tissue plasminogen activator and gas in subretinal hemorrhage caused by age-related macular degeneration. Retina 2000:251-6.
8. Boone DE, Boldt HC, Ross RD, Folk JC, Kimura AE. The use of intravitreal tissue plasminogen activator in the treatment of experimental subretinal hemorrhage in the pig model. Retina. 1996;16(6):518-24.
9. Coll GE, Sparrow JR, Marinovic A, Chang S. Effect of intravitreal tissue plasminogen activator on experimental subretinal hemorrhage. Retina. 1995;15(4):319-26.
10. Lewis H, Resnick SC, Flannery JG, Straatsma BR. Tissue plasminogen activator treatment of experimental subretinal hemorrhage. Am J Ophthalmol. 1991 Feb 15;111(2):197-204.
11. Toth CA, Morse LS, Hjelmeland LM, Landers MB 3rd.Fibrin directs early retinal damage after experimental subretinal hemorrhage. Arch Ophthalmol. 1991;109(5):723-9.
12. Sawa M, Ober MD, Freund KB, Spaide RF. Fundus autofluorescence in patients with pseudoxanthoma elasticum. Ophthalmology. 2006;113:814-20.e2
13. Stanescu-Segall D, Balta F, Jackson TL.Submacular hemorrhage in neovascular age-related macular degeneration: A synthesis of the literature. Surv Ophthalmol. 2016 Jan-Feb;61(1):18-32.
14. Steel DHW, Sandhu SS. Submacular haemorrhages associated with neovascular age-related macular degeneration. Br J Ophthalmol 2011; 95 (8): 1051–7.
15. Fine HF, Iranmanesh R, Del Priore LV et al. Surgical outcomes after massive subretinal hemorrhage secondary to age-related macular degeneration. Retina 2010; 30 (10): 1588–94.
16. Scupola A, Coscas G, Soubrane G, Balestrazzi E.Natural history of macular subretinal hemorrhage in agerelated macular degeneration. Ophthalmologica 1999; 213 (2): 97–102.
17. Shin K-H, Lee TG, Kim JH et al. The effi cacy of intravitreal afl ibercept in submacular hemorrhage secondary to wet age-related macular degeneration. Korean J Ophthalmol 2016; 30 (5): 369–76

Intravitreal Aflibercept in a Case of Submacular Hemorrhage

Year 2021, Volume: 10 Issue: 2, 295 - 299, 31.08.2021

Emine Çakar , Saadet Gültekin Irgat Fatih Özcura

Abstract

References

1. Dr. Kenan Sönmez. Submacular Hemorrhage and Its Management. Turkiye Klinikleri J Ophthalmol-Special Topics. 2009;2(2):72-82
2. Paradee Kunavisarut, MD, Tipparut Thithuan, MD, Direk Patikulsila, MD, et al. Submacular Hemorrhage: Visual Outcomes and Prognostic Factors. Asia Pac J Ophthalmol (Phila). 2018 Mar-Apr;7(2):109-13.
3. Mehmet Çakır, Ziya Kapran, Tuğrul Atlan et al. Subretinal t-PA and Pneumatic Displacement in Submacular Hemorrhage. Ret-Vit. 2005;13:Özel Sayı 19-21
4. Avery RL, Fekrat S, Hawkins BS, Bressler NM. Natural histury of subfoveal subretinal hemorrhage in age-related macular degeneration. Retina 1996;16:183-9.
5. Glatt H, Machemer R.: Experimental subretinal hemorrhage in rabbits. Am J Ophthalmol 1996;122:484-93.
6. Tennant MT, Borillo JL, Regillo CD. Management of submacular hemorrhage. Ophthalmol Clin Nort Am. 2002;15:445-52.
7. Krepler K, Kruger A, Tittl M, Stur M, Wedrich A. Intravitreal injection of tissue plasminogen activator and gas in subretinal hemorrhage caused by age-related macular degeneration. Retina 2000:251-6.
8. Boone DE, Boldt HC, Ross RD, Folk JC, Kimura AE. The use of intravitreal tissue plasminogen activator in the treatment of experimental subretinal hemorrhage in the pig model. Retina. 1996;16(6):518-24.
9. Coll GE, Sparrow JR, Marinovic A, Chang S. Effect of intravitreal tissue plasminogen activator on experimental subretinal hemorrhage. Retina. 1995;15(4):319-26.
10. Lewis H, Resnick SC, Flannery JG, Straatsma BR. Tissue plasminogen activator treatment of experimental subretinal hemorrhage. Am J Ophthalmol. 1991 Feb 15;111(2):197-204.
11. Toth CA, Morse LS, Hjelmeland LM, Landers MB 3rd.Fibrin directs early retinal damage after experimental subretinal hemorrhage. Arch Ophthalmol. 1991;109(5):723-9.
12. Sawa M, Ober MD, Freund KB, Spaide RF. Fundus autofluorescence in patients with pseudoxanthoma elasticum. Ophthalmology. 2006;113:814-20.e2
13. Stanescu-Segall D, Balta F, Jackson TL.Submacular hemorrhage in neovascular age-related macular degeneration: A synthesis of the literature. Surv Ophthalmol. 2016 Jan-Feb;61(1):18-32.
14. Steel DHW, Sandhu SS. Submacular haemorrhages associated with neovascular age-related macular degeneration. Br J Ophthalmol 2011; 95 (8): 1051–7.
15. Fine HF, Iranmanesh R, Del Priore LV et al. Surgical outcomes after massive subretinal hemorrhage secondary to age-related macular degeneration. Retina 2010; 30 (10): 1588–94.
16. Scupola A, Coscas G, Soubrane G, Balestrazzi E.Natural history of macular subretinal hemorrhage in agerelated macular degeneration. Ophthalmologica 1999; 213 (2): 97–102.
17. Shin K-H, Lee TG, Kim JH et al. The effi cacy of intravitreal afl ibercept in submacular hemorrhage secondary to wet age-related macular degeneration. Korean J Ophthalmol 2016; 30 (5): 369–76

There are 17 citations in total.

Details

Primary Language	Turkish
Subjects	Clinical Sciences
Journal Section	Case Report
Authors	Emine Çakar 0000-0001-6532-0249 Saadet Gültekin Irgat This is me 0000-0001-5289-7962 Fatih Özcura This is me 0000-0001-6482-180X
Publication Date	August 31, 2021
Submission Date	January 4, 2021
Published in Issue	Year 2021 Volume: 10 Issue: 2

Cite

APA	Çakar, E., Gültekin Irgat, S., & Özcura, F. (2021). Submakuler Hemoraji Olgusunda İntravitreal Aflibersept. Abant Medical Journal, 10(2), 295-299. https://doi.org/10.47493/abantmedj.853734
AMA	Çakar E, Gültekin Irgat S, Özcura F. Submakuler Hemoraji Olgusunda İntravitreal Aflibersept. Abant Med J. August 2021;10(2):295-299. doi:10.47493/abantmedj.853734
Chicago	Çakar, Emine, Saadet Gültekin Irgat, and Fatih Özcura. “Submakuler Hemoraji Olgusunda İntravitreal Aflibersept”. Abant Medical Journal 10, no. 2 (August 2021): 295-99. https://doi.org/10.47493/abantmedj.853734.
EndNote	Çakar E, Gültekin Irgat S, Özcura F (August 1, 2021) Submakuler Hemoraji Olgusunda İntravitreal Aflibersept. Abant Medical Journal 10 2 295–299.
IEEE	E. Çakar, S. Gültekin Irgat, and F. Özcura, “Submakuler Hemoraji Olgusunda İntravitreal Aflibersept”, Abant Med J, vol. 10, no. 2, pp. 295–299, 2021, doi: 10.47493/abantmedj.853734.
ISNAD	Çakar, Emine et al. “Submakuler Hemoraji Olgusunda İntravitreal Aflibersept”. Abant Medical Journal 10/2 (August 2021), 295-299. https://doi.org/10.47493/abantmedj.853734.
JAMA	Çakar E, Gültekin Irgat S, Özcura F. Submakuler Hemoraji Olgusunda İntravitreal Aflibersept. Abant Med J. 2021;10:295–299.
MLA	Çakar, Emine et al. “Submakuler Hemoraji Olgusunda İntravitreal Aflibersept”. Abant Medical Journal, vol. 10, no. 2, 2021, pp. 295-9, doi:10.47493/abantmedj.853734.
Vancouver	Çakar E, Gültekin Irgat S, Özcura F. Submakuler Hemoraji Olgusunda İntravitreal Aflibersept. Abant Med J. 2021;10(2):295-9.

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