Ceftazidime-Induced Non-Convulsive Status Epilepticus (NCSE) in a Pediatric Patient with Literature Review

Year 2024, Volume: 13 Issue: 2, 85 - 93

Mehpare Sarı Yanartaş Sait Açık Özlem Yayıcı Köken Gülşah Aksoy Şenay Haspolat

https://doi.org/10.47493/abantmedj.1413064

Abstract

Cephalosporins are a class of antibiotics routinely prescribed for a variety of pediatric infections. Among uncommon adverse effects, cephalosporins can be neurotoxic and epileptogenic, particularly in patients with reduced renal function. Neurotoxic effects are most frequently observed in adults with impaired renal function, and they have rarely been recorded in children. An 11-year-old boy with chronic renal failure experienced non-convulsive status epilepticus two days after initiating intravenous cefazolin and ceftazidime with a pre-diagnosis of peritonitis. The patient's mental condition reverted to baseline within hours after intravenous antibiotic treatment was discontinued and appropriate antiepileptic and anticonvulsive therapy was started. Providers should investigate cephalosporin-induced non-convulsive status epilepticus clinically and electrophysiologically in any child with renal impairment who demonstrates acute changes in mental status or decreased awareness after initiating intravenous cephalosporins.

Keywords

ephalosporin, non-convulsive status epilepticus, renal failure

Pediatrik Hastada Seftazidime Bağlı Non-Konvülsif Status Epileptikus (NKSE) Olgusu; Literatür Derlemesi ile

Abstract

Sefalosporinler, çeşitli pediatrik enfeksiyonların tedavisinde rutin olarak reçete edilen bir antibiyotik sınıfıdır. Seyrek görülen yan etkiler arasında, sefalosporinlerin özellikle böbrek fonksiyonu azalmış hastalarda nörotoksik ve epileptojenik olabileceği belirtilmiştir. Nörotoksik etkiler, özellikle böbrek fonksiyonu bozulmuş yetişkinlerde daha sık gözlenirken, çocuklarda nadiren bildirilmiştir. Kronik böbrek yetmezliği tanısı ile takip edilen 11 yaşındaki erkek hastada peritonit ön tanısı ile intravenöz sefazolin ve seftazidim tedavisine başladıktan iki gün sonra non-konvülsif status epileptikus tablosu gelişmiştir. Hasta intravenöz antibiyotik tedavisinin kesilmesi ve uygun antikonvülsan tedavinin başlatılmasının ardından birkaç saat içinde mental durumu normale dönmüştür. İntravenöz sefalosporin başlanmasının ardından akut mental durum değişiklikleri gösteren her çocuk hastada klinik ve elektrofizyolojik olarak sefalosporin kaynaklı non-konvülsif status epileptikus akla gelmesi gereken ön tanılardan biridir.

Keywords

sefalosporin, nonkonvulzif status epileptikus, renal yetmezlik

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