Investigation of Amyloid Accumulation in Postoperative Gallbladder Material

Year 2025, Volume: 14 Issue: 2, 79 - 83, 29.08.2025

Ali Osman Avcı , Emre Akarsu , Hesna Müzeyyen Astarcı

https://doi.org/10.47493/abantmedj.1673424

Abstract

Objective: Amyloid deposition in the gallbladder and biliary tract is a relatively underexplored area in the medical literature. The frequency of amyloid deposition in gallbladders after cholecystectomy remains unclear. The present study aims to address this gap in knowledge by investigating amyloid deposition in postoperative gallbladder materials.
Materials and Methods: The study comprised adult patients over the age of 18 who had undergone cholecystectomy for gallstones. Tissue samples taken from the fundus, corpus, and neck regions of the postoperative gallbladder were cut into 5-micron thicknesses for routine examination, stained with hematoxylin-eosin, and then stained with Congo red to search for amyloid deposits under a polarized light.
Results: The study involved 100 patients (57 females, 43 males). The average age of female patients was 46.49 ± 16.20 years, and for male patients, it was 49.58 ± 14.91 years. No amyloid deposition was observed in any gallbladder tissue sample.
Conclusion: It was concluded that it is not necessary to look for amyloid deposits in gallbladder material after cholecystectomy, regardless of the patient's age, gender, concomitant diseases, duration and composition of gallstones.

Keywords

cholecystectomy , gallbladder , amyloidosis

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