Relationship Between Forensic Behavioral Genetics and Gut Microbiota

Abstract

Genetic basis of human behavior is investigated in psychiatry, neurology, biology, forensic science, sociology and many different discip- lines, and results of studies are shared with scientific publications. In recent years, it is founded the correlation between brain and gut micro- biome is more different and complicated than it should be. That differences come from excess of nerve impulses between the intestine and brain. Ano- ther important aspect of the intestine is the effects of the microorganisms it contains on human metabolism, hormones, psychology and behavioral states. Each microorganisms present in human gut microbiota has its own metabo- lism, exchange nutrients and various microbial secretions. These secretions have various properties and are involved in metabolism with other digested nutrients from the intestinal wall. This causes various effects on human physiology, and these effects can also be reflected in the psychological state of a person. From a forensic perspective, it may be thought that the effect of the type and type of microorganism in a person’s microbiome on brain fun- ctions may be reflected in the behavior of the person, and if these behaviors are negative, the person may be prone to crime. In our study, it is discussed impact of the human intestinal flora on the behavior of people that can be involved to crimes as victims or crime per- petrators in terms of forensic science.

Adli Davranış Genetiği ve Bağırsak Florası İlişkisi

Abstract

Davranışların genetik temeli, psikiyatri, nöroloji, biyoloji, adli bilim- ler, sosyoloji ve birçok farklı disiplinde çalışılmakta ve bilimsel yayınlar ile çalışmaların sonuçları paylaşılmaktadır. Son yıllarda, beyin – bağırsak arasındaki sinirsel uyarıların fazlalığından dolayı iki organ arasındaki ilişkinin sanılandan çok daha kapsamlı boyutta olduğu saptanmıştır. Bağırsakların bir diğer önemli yanının, içerdiği mik- roorganizmaların insan metabolizmasına, hormonlara, psikolojiye ve dav- ranış durumlarına olan etkileri olduğu düşünülmektedir. İnsan bağırsağı içerisinde bulunan mikroorganizmaların her birinin kendine ait metabolizması, bağırsakla besin alışverişi ve çeşitli mikrobiyal salgıları vardır. Bu salgılar çeşitli özelliklerde olup, bağırsak duvarından diğer sindirilmiş besinlerle beraber metabolizmaya karışmaktadırlar. Bu da insan fizyolojisi üzerinde çeşitli etkilere sebep olmakta, bu etkiler kişinin psikolojik durumuna da yansıyabilmektedir. Adli açıdan değerlendirildiğinde, kişinin mikrobiyotasındaki mikroorganizma sayı ve tür çeşidinin, beyin fonksiyonları üzerindeki etkisinin kişinin davranışlarına yansıyabileceği ve bu davranışların olumsuz olması durumunda kişinin suça meyilli olabileceği sonucuna varmak mümkün olabilir. Çalışmamızda, insan bağırsak florasının suça fail veya mağdur olarak karı- şabilecek kişilerin davranışları üzerindeki etkileri, adli bilimler yönünden tartışılmıştır.

Keywords

• Davranış Genetiği
• Suç
• Mikrobiyota
• Bağırsak
• Beyin

References

1. Abay, E., Tuğlu C., (2000). Şiddet ve Agresyonun Nörobiyolojisi, Klinik Psikiyatri Dergisi. 2000;3, ss.21-26
2. Alam, R., Abdolmaleky, H. M., & Zhou, J.-R. (2017). Microbiome, inflammation, epigenetic alterations, and mental diseases. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 174(6), pp. 651–660. doi:10.1002/ajmg.b.32567
3. Altuner, D., Engin, N., Gürer, C., Akyay, İ., Akgül, A. (2009). Madde Kullanımı ve Suç İlişkisi: Kesitsel Bir Araştırma. Tıp Araştırmaları Dergisi, 7(2), ss. 87-94.
4. Allis, C., Jenuwein, T. The molecular hallmarks of epigenetic control. Nat Rev Genet 17, pp.487–500 (2016). https://doi.org/10.1038/nrg.2016.59
5. Bloomfield, P. S., Selvaraj, S., Veronese, M., Rizzo, G., Bertoldo, A., Owen, D. R., ... Howes, O. D. (2016). Microglial activity in people at ultra high risk of psychosis and in schizophrenia: An [(11)C]PBR28 PET brain imaging study. The American Journal of Psychiatry, 173, pp.44–52.
6. Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., Cryan, J. F. (2014). The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential. in Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. pp. 373-403). Springer New York.
7. Book, A. S., Starzyk, K. B., & Quinsey, V. L. (2001). The relationship between testosterone and aggression: a meta-analysis. Aggression and Violent Behavior, 6(6), pp.579–599.
8. Bouchard, J., Loehlin, J., (2001). Genes, Evolution, and Personality. Behavior Genetics, 31(3), pp. 243-273.

9. Caspi, A., McClay, J., Moffitt, T.E., Mill, J., Martin, J., Craig, I.W., Taylor, A. and Poulton, R. (2002), Role of genotype in the cycle of violence in maltreated children, Science, vol. 297 no. 5582, pp. 851-854.
10. Caspi, C. E., Sorensen, G., Subramanian, S. V., & Kawachi, I. (2012). Thelocal food environment and diet: A systematic review.Health &Place,18(5), pp.1172–1187
11. Cenit, M. C., Sanz, Y., & Codoñer-Franch, P. (2017). Influence of gut microbiota on neuropsychiatric disorders. World journal of gastroenterology, 23(30), pp.5486–5498. https://doi.org/10.3748/wjg.v23.i30.5486
12. Chen, X., Hackett, P.D., DeMarco, A.C. et al. (2016). Effects of oxytocin and vasopressin on the neural response to unreciprocated cooperation within brain regions involved in stress and anxiety in men and women. Brain Imaging and Behavior 10, pp.581–593 https://doi.org/10.1007/s11682-015-9411-7
13. Chinna Meyyappan, A., Forth, E., Wallace, C. J. K., & Milev, R. (2020). Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review. BMC Psychiatry, 20(1). doi:10.1186/s12888-020-02654-5
14. Choy, O., & Raine, A. (2021). Vitamin D sufficiency attenuates the effect of early social adversity on child antisocial behavior. Psychological Medicine, pp.1-10. doi:10.1017/ S0033291721001069
15. Coccaro, E,F., McNamee, B., (1998). Biology of Agression: Relevance to Crime. Psychopathology and Violent Crime, AE Skodol (Ed), Washington, American Psychiatric Press, s.99-128. Aktaran: Abay, E., Tuğlu C., (2000) Şiddet ve Agresyonun Nörobiyolojisi Klinik Psikiyatri Dergisi 2000;3, pp.21-26
16. Cura, D. O., & Çankaya, T. (2017). Genetik faktörlerin şiddet davranışı üzerine etkisi. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 31(2), ss.97-102.
17. Crews, D. (2011). Epigenetic modifications of brain and behavior: Theory and practice. Hormones and Behavior, 59(3), pp. 393–398. doi:10.1016/j.yhbeh.2010.07.001
18. Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., Dinan, T. G. (2008). The Probiotic Bifidobacteria infantis: an Assessment of Potential Antidepressant Properties in the Rat. Journal of psychiatric research, 43(2), pp. 164-174.
19. DiLalla, L. F. (2004). Behavior Genetics Principles: Perspectives in Development, Personality, and Psychopathology. American Psychological Association
20. Evren, C., Tamar, D., Ögel, K., Çorapçıoğlu, A., Çakmak, D. (2000). Damar Yolu ile Eroin Kullanımı ve İlişkili Bazı Davranış Biçimleri. Türkiye Psikiyatri Dergisi, 1, ss.220- 224.
21. Evrensel, A., & Ceylan, M. E. (2015). Bağırsak Beyin Ekseni: Psikiyatrik Bozukluklarda Bağırsak Mikrobiyotasının Rolü. Psikiyatride Güncel Yaklaşımlar, 7(4), ss. 461-472.
22. Feng, C., DeMarco, A. C., Haroon, E., & Rilling, J. K. (2015). Neuroticism modulates the effects of intranasal vasopressin treatment on the neural response to positive and negative social interactions. Neuropsychologia, 73, pp.108–115.
23. Fung, T. C., Olson, C. A., & Hsiao, E. Y. (2017). Interactions between the microbiota, immune and nervous systems in health and disease. Nature Neuroscience, 20(2), pp. 145–155. doi:10.1038/nn.4476
24. Gülşah, K. O. Ç. (2018). Nutrigenomik: Genotipten Fenotipe Beslenme Etkisi. Tıp Fakültesi Klinikleri Dergisi, 1(1), ss.79-92.
25. Gültekin, T., & Gökçümen, Ö. (2009). Genetik Bilgi ve Antropoloji. Tübitak Bilim Teknik Dergisi, s.494.
26. Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., ...
27. Cryan, J. F. (2016). Regulation of prefrontal cortex myelination by the microbiota. Translational Psychiatry, 6(4), p.774
28. Hooks, K. B., Konsman, J. P., & O’Malley, M. A. (2019). Microbiota-gut-brain research: a critical analysis. Behavioral and Brain Sciences, p.42.
29. Hornig, M. (2013). The Role of Microbes and Autoimmunity in the Pathogenesis of Neuropsychiatric Illess. Current Opinion in Rheumatology, 25(4), pp.488-795.
30. Jandhyala, S. M., Talukdar, R., Subramanyam, C., Vuyyuru, H., Sasikala, M., & Nageshwar Reddy, D. (2015). Role of the normal gut microbiota. World journal of gastroenterology, 21(29), pp. 8787–8803. https://doi.org/10.3748/wjg.v21.i29.8787
31. Karabay, A., Saija, J. D., Field, D. T., & Akyürek, E. G. (2018). The acute effects of cocoa flavanols on temporal and spatial attention. Psychopharmacology, 235(5), pp. 1497- 1511. https://doi.org/10.1007/ s00213-018-4861-4
32. Karataş, O., Karabay, A., & Alıcı, T. (2022). Uzun Süreli Kakao Flavanolleri Alımının Bilişsel İşlevlere ve Duygudurumuna Etkileri ve Bu Etkilerin Altındaki Fizyolojik Mekanizmalar: Bir Derleme Çalışması. Türk Psikoloji Yazıları, 25(49), ss.1-26.
33. Khanna, S., & Tosh, P. K., (2014),. A Clinician’s Primer On The Role Of The Microbiome in Human Health and Disease. In Mayo Clinic Proceedings Vol. 89, No. 1, pp. 107- 114. Elsevier.
34. Liu, J., Raine, A., Venables, P. H., & Mednick, S. A. (2004). Malnutrition at age 3 Years and Externalizing Behavior Problems at ages 8, 11, and 17 Years. American Journal of Psychiatry, 161(11), pp.2005-2013.
35. Lyte, M. (2011). Probiotics Function Mechanistically as Delivery Vehicles for Neuroactive Compounds: Microbial Endocrinology in the Design and Use of Probiotics. Bioessays, 33(8), pp. 574-581.
36. MacQueen, G., Surette, M., & Moayyedi, P. (2017). The gut microbiota and psychiatric illness. Journal of Psychiatry & Neuroscience, 42(2), pp.75–77. doi:10.1503/ jpn.170028
37. Messaoudi, M., Violle, N., Bisson, J. F., Desor, D., Javelot, H., & Rougeot, C. (2011). Beneficial Psychological Effects of a Probiotic Formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in Healthy Human Volunteers. Gut Microbes, 2(4),pp. 256-261.
38. Meyer, U., Feldon, J., & Dammann, O. (2011). Schizophrenia and autism: Both shared and disorder-specific pathogenesis via perinatal inflammation? Pediatric Research, 69, pp.26-33.
39. Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014). Correlation Between The Human Fecal Microbiota And Depression. Neurogastroenterology & Motility, 26(8), pp.1155-1162.
40. O’Hara, A. M., & Shanahan, F. (2006). The gut flora as a forgotten organ. EMBO Reports, 7(7), pp.688–693. doi:10.1038/sj.embor.7400731
41. Paul, B., Barnes, S., Demark-Wahnefried, W., Morrow, C., Salvador, C., Skibola, C., & Tollefsbol, T. O. (2015). Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases. Clinical Epigenetics, 7, p.112.
42. Portnoy, J., McGouldrick, S. H., Raine, A., Zemel, B. S., Tucker, K. L., &Liu, J. (2021). Lower dietary intake of magnesium is associated withmore callous–unemotional traits in children.Nutritional Neuroscience,pp.1–10.
43. Raimondi, I., Izzo, L., Tunesi, M., Comar, M., Albani, D., & Giordano, C. (2020). Organon- a-chip in vitro models of the brain and the blood-brain barrier and their value to study the microbiota-gut-brain axis in neurodegeneration. Frontiers in Bioengineering and Biotechnology, 7, 435, pp.1-17.
44. Ridaura, V., & Belkaid, Y. (2015). Gut Microbiota: The Link to Your Second Brain. Cell, 161(2), pp.193–194. doi:10.1016/j.cell.2015.03.033
45. Rook, G. A., Lowry, C. A., & Raison, C. L. (2014). Hygiene And Other Early Childhood Influences on the Subsequent Function of the Immune System. Brain Research.
46. Rosales FJ, Reznick JS, Zeisel SH, (2009). Understanding the Role of Nutrition in the Brain and Behavioral Development of Toddlers and Preschool Children: Identifying and Addressing Methodological Barriers. Nutritional Neuroscience 12(5), pp.190-202.
47. Sampson, T. R., & Mazmanian, S. K. (2015). Control of brain development, function, and behavior by the microbiome. Cell Host & Microbe, 17(5), pp. 565–576.
48. Small, D. M., Zatorre, R. J., Dagher, A., Evans, A. C., & Jones-Gotman, M. (2001). Changes in Brain Activity Related To Eating Chocolate. Brain, 124(9), pp. 1720-1733.
49. Smeeth, D., Beck, S., Karam, E. G., & Pluess, M. (2021). The role of epigenetics in psychological resilience. The Lancet Psychiatry, 8(7), pp. 620–629. doi:10.1016/ s2215-0366(20)30515-0
50. Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2013). Microbial genes, brain & behaviour - epigenetic regulation of the gut-brain axis. Genes, Brain and Behavior, 13(1), pp. 69–86. doi:10.1111/gbb.12109
51. Tcherni-Buzzeo, M. (2022). Dietary interventions, the gut microbiome, and aggressive behavior: Review of research evidence and potential next steps. Aggressive Behavior. https://doi.org/10.1002/ab.22050
52. Thursby, E., & Juge, N. (2017). Introduction to the human gut microbiota. Biochemical Journal, 474(11), pp.1823–1836. doi:10.1042/bcj20160510
53. Topçuoğlu, P. (2015) Gastrointestinal Sistem Toksisitesi. Hematolojide Destek Tedavileri ve İnfeksiyonlar Kursu, 16-18. http://scholar.googleusercontent.com/scholar?q=cache:x SEVTwEJda8J:scholar.google.com/+kemoterapi+ba%C4%9F%C4%B1rsak+ floras%C4%B1 &hl=tr&as_sdt=0,5 Erişim Tarihi: 04.10.2015
54. Uhde, T. W., & Tancer, M. E. (1995). Benzodiazepine Receptor Agonists And Antagonists. Comprehensive textbook of psychiatry V, 2, p.1939.
55. Virkkunen, M., Rawlings, R., Tokola, R., Poland, R. E., Guidotti, A., Nemeroff, C., ... & Linnoila, M. (1994). CSF Biochemistries, Glucose Metabolism, And Diurnal Activity Rhythms İn Alcoholic, Violent Offenders, Fire Setters, And Healthy Volunteers. Archives of General Psychiatry, 51(1), pp.20-27.
56. Walton, J. S. (2021). Fit in your genes: an introduction to genes and epigenetics for forensic practitioners. The Journal of Forensic Practice. pp.189-200.
57. Woo, V and Alenghat, T. (2022). Epigenetic regulation by gut microbiota, Gut Microbes, 14:1, DOI: 10.1080/19490976.2021.2022407
58. Yang Q-Q, Sun J-W, Shao D, Zhang H-H, Bai C-F, Cao F-L. The Association between Diabetes Complications, Diabetes Distress, and Depressive Symptoms in Patients with Type 2 Diabetes Mellitus. Clinical Nursing Research. 2021;30(3), pp. 293-301.
59. Yang, X., Wang, W., Wang, X. T., & Wang, Y. W. (2021). A meta-analysis of hormone administration effects on cooperative behaviours: Oxytocin, vasopressin, and testosterone. Neuroscience & Biobehavioral Reviews, 126, pp.430–443.
60. Yarar, M. (2003) Dopamin DRD2 Geni Polimorfizmi ve Eroin Bağımlılığı, Yüksek Lisans Tezi, İstanbul Üniversitesi Adli Tıp Enstitüsü Kütüphanesi.
61. Yüksel, N. (2001). İntiharın Nörobiyolojisi. Klinik Psikiyatri Dergisi, 2, ss. 5-15.
62. Zhu, B., Wang, X. & Li, L. (2010) Human gut microbiome: the second genome of human body. Protein Cell 1, pp. 718–725
63. Zimmerman, G. M., & Posick, C. (2016). Risk factors for and behavioralconsequences of direct versus indirect exposure to violence.American Journal of Public Health,106(1), pp. 178–188.