Gestasyonel Diyabette Plazma Ürotensin II Konsantrasyonu

Öz

Amaç: Urotensin II (UII) ve sistemi, birçok hastalığın (diyabet dahil) etyolojisinde rol oynar. Bu çalışmada gestasyonel diabetes mellitusta (GDM) UII'yi değerlendirmek ve karşılaştırmayı denedik.

Yöntemler: Çalışmaya alınan otuzaltı gebe (GDM olmayan 15 kadın hasta 1. Grubu ve 21 GDM kadın hasta 2. Grubu  oluşturdu). Üçüncü grup, yaşları eşleştirilmiş 22 gebe olmayan sağlıklı bireyden oluşuyordu. Plazma UII seviyeleri çalışmanın başında belirlendi. Doğum sonrası 12.hafta ikinci bir plazma UII düzeyi grup 1 ve 2 'deki hastalardan ölçüldü.

Bulgular: Hem GDM hem de GDM olmayan deneklerin Gestasyonel UII düzeyleri, gebe olmayan sağlıklı kontrollere göre daha yüksekti (her ikisi için p=0,0001). GDM'li hastaların gestasyonel ve postpartum UII düzeyleri, GDM'li olmayan gebelere göre daha yüksekti ancak istatistiksel olarak anlamlı değildi (p≥0.05). GDM'li olmayan kişilerde plazma UII konsantrasyonları, doğumdan sonra anlamlı olarak azaldı, ancak GDM'li kişilerde değişmedi (sırasıyla, p=0,036 ve p ≥0.05).

Sonuç: GDM hastalarında doğumdan sonra anlamlı bir şekilde azalmayan plazma UII konsantrasyonlarının yüksek bulunması (GDM olmayan bireylerle karşılaştırıldığında), UII'nin ve sisteminin GDM patogenezinde rol oynayabileceğini göstermektedir. Bu alanda daha ayrıntılı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• ürotensin,gestasyonel diabet,gebelik,glukoz tolerans testi

Plasma Urotensin II Concentration In Gestational Diabetes

Abstract

Aim: Urotensin II (UII) and its system is implicated in the etiology of many diseases (including diabetes mellitus). We tried in this study to evaluate and compare UII levels in gestational diabetes mellitus (GDM).

Methods: Thirty-six pregnant women (15 non-GDM patients consisted group 1 and 21 GDM patients consisted group 2) enrolled in this study. The 3rd group consisted of age matched 22 non pregnant healthy women. Plasma UII levels were determined at the beginning of the study. After 12 weeks of delivery, a second plasma UII was determined from group 1 and 2.

Results: Gestational UII levels of both GDM and non-GDM patients were higher than non-pregnant healthy controls (p=0.0001 for both). Both gestational and postpartum UII levels of GDM patients were higher than non-GDM patients but had not reached statistical significance (P≥0.05). Plasma UII concentrations in non-GDM patients significantly decreased after delivery but not in GDM patients (p=0.036 and p≥0.05, respectively).

Conclusion: The finding of elevated gestational plasma UII concentrations in GDM patients which did not decrease significantly after delivery (in compare to non-GDM patients) shows that plasma UII levels may have a role in the pathogenesis of GDM. Further detailed studies are needed in this field.

Keywords

• urotensin,gestational diabetes,pregnancy,glucose tolerance test

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