Diyabetik ve prediabetik hastalarda serum magnezyum ve serum glukoz düzeyleri ile HOMA-IR arasındaki ilişkinin değerlendirilmesi

Year 2019, , 6 - 9, 15.03.2019

Gülçin Şahingöz Erdal , Faruk Karandere Fuat Mısıroğlu İşıl Özbaş Tevetoğlu Yıldız Okuturlar , Hakan Koçoğlu Mehmet Hurşitoğlu

https://doi.org/10.25000/acem.451930

Cited By: 2

Abstract

Amaç: Bu çalışmada diyabetik ve prediyabetik
hastalarda serum magnezyum (Mg) düzeyleri ile yaş, vücut kitle indeksi,
HOMA-IR, serum açlık glukoz, HbA1c ve insülin düzeyleri arasındaki ilişkiyi inceledik.

Yöntemler: Bu retrospektif çalışmada, yeni
tanı almış prediyabet (Grup PD) (n=63) ve tip 2 diabetes mellitus (Grup D) (n=67)
olmak üzere toplam 130 hasta çalışmaya alındı. Hastaların yaşı, vücut kitle
indeksi, serum Mg, glukoz ve insülin değerleri, HOMA-IR ve HbA1c kaydedildi.
Prediabetes ve tip 2 diyabet tanısı, tanı anında WHO kriterlerine göre yapıldı.

Bulgular: Grup D'de ortalama Mg düzeyi (1,88
± 0,17 mg/dl), grup PD'den (1,96 ± 0,17 mg/dl) anlamlı derecede düşüktü (p = 0,007).
Korelasyon analizi, D grubunda Mg ve glukoz (r = -0,390, p = 0,001) ve HOMA-IR
(r = -0,284; p = 0,022) arasında anlamlı negatif korelasyon olduğunu gösterdi.
Serum Mg ile insülin, HbA1c, yaş ve vücut kütle indeksi (sırasıyla p = 0,801, 0,087,
0,611 ve 0,691) arasında korelasyon saptanmadı. Grup PD'de serum insülin,
HbA1c, glukoz, HOMA-IR, yaş ve vücut kitle indeksi ile serum Mg düzeyleri arasında
korelasyon yoktu (sırasıyla p = 0,801, 0,087, 0,939, 0,998, 0,611 ve 0,691).

Sonuçlar: Diyabetik
hastalarda magnezyum düzeyleri ile HOMA-IR ve açlık kan glikoz düzeyleri
arasında negatif bir ilişki olduğunu, ancak bu ilişkinin prediyabetik
hastalarda mevcut olmadığını gösterdik. Çalışma sonuçlarımız serum Mg seviyesinin
tip 2 diyabetin metabolik kontrolü ile ilişkili olduğunu ve bu nedenle bu
hastalarda göz önüne alınabileceğini düşündürmektedir.

Keywords

Magnezyum, diyabet, prediyabet, insülin direnci, açlık glukoz, HOMA-IR

Assessment of relationship between serum magnesium and serum glucose levels and HOMA-IR in diabetic and prediabetic patients

Abstract

Aim: In this study, we aimed to investigate
the serum magnesium (Mg) levels in diabetic and prediabetic patients and its
correlation with age, body-mass index, HOMA-IR, serum fasting glucose, HbA1c,
and insulin levels.

Methods: In this retrospective study, a total
of 130 patients consisted of newly diagnosed prediabetes (Group PD) (n=63) and
type 2 diabetes mellitus (Group D) (n=67) were included. Patients' age, body
mass index, serum Mg, glucose and insulin, HOMA-IR and HbA1c were recorded. The
prediabetes and type 2 diabetes diagnoses had been made according to WHO
criteria at the time of diagnosis.

Results: In group D, the mean Mg level (1.88
± 0.17 mg/dl) was significantly lower than group PD (1.96 ± 0.17 mg/dl) (p = 0.007).
Correlation analysis showed that there was a significant negative correlation
between Mg and glucose (r = -0.390, p = 0.001) and HOMA-IR (r = -0.284; p = 0.022)
in the group D. No correlation was found between serum Mg level and serum
insulin, HbA1c, age, and body-mass index (p = 0.801, 0.087, 0.611 and 0.691,
respectively). In group PD, serum insulin, HbA1c, glucose, HOMA-IR, age, and
body-mass index were not corraleted with serum Mg levels (p = 0.801, 0.087, 0.939,
0.998, 0.611 and 0.691, respectively).

Conclusıon: We showed
that while there was a negative correlation between magnesium levels and
HOMA-IR and fasting blood glucose levels in diabetic patients, but this
correlation was not present in prediabetic patients. Our results suggest that
serum Mg level is associated with metabolic control of type 2 diabetes and thus
it can be considered in these patients.

Keywords

Magnesium, Diabetes, Prediabetes, Insulin resistance, Fasting glucose, HOMA-IR

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