Effects of chronic obstructive pulmonary disease stage on muscle oxygenation during exercise

Year 2023, , 518 - 525, 27.10.2023

Gülhan Yılmaz Gökmen , Canan Demir

https://doi.org/10.38053/acmj.1366947

Abstract

Aims: The aim of this study was to investigate peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD) at rest, during submaximal exercise, and during recovery, and to determine the effects of disease stage on peripheral muscle oxygenation.
Methods: Of the 35 stable COPD patients (62.49±8.45 years), 18 patients in GOLD 1 and 2 were assigned to Group 1 and 17 patients in GOLD 3 and 4 were assigned to Group 2. Dyspnea perception of the patients was evaluated with the Modified Medical Research Council (mMRC) Dyspnea Scale, severity of the disease affecting daily life was evaluated with the COPD Assessment Test (CAT-COPD Assessment Test), respiratory function was evaluated with the Pulmonary Function Test, and quadriceps muscle strength was evaluated with a manual muscle testing device. Muscle oxygenation of the patients was measured with Near-infrared spectroscopy (NIRS) for 5 minutes at rest, 6 minutes during the 6-Minute Walk Test (6-MWT), and 5 minutes during recovery after the end of the test. The results of the two groups were compared.
Results: Intragroup comparisons of muscle oxygenation at rest, during 6-MWT and during recovery; in Group 1, there was a statistically significant decrease between resting SmO2 mean and test SmO2 mean (p=0.001), a increase between test SmO2 mean and recovery SmO2 mean (p<0.001), and a significant increase between resting SmO2 mean and recovery SmO2 mean (p=0.022). In Group 2, there was a statistically significant decrease between resting SmO2 mean and SmO2 mean during the test (p=0.002), increase between resting SmO2 mean and recovery SmO2 mean (p<0.001*), and resting SmO2 mean and recovery SmO2 mean (p=0.024). There was no significant difference between the groups in Δ Rest-Test SmO2mean, Δ Recovery-Test SmO2mean, and Δ Recovery-Rest SmO2mean (p>0.05). In the SmO2 comparison of Group 1 and Group 2 at rest, during 6-MWT, and during recovery, it was observed that the test SmO2mean value was statistically higher in Group 2 (p=0.023).
Conclusion: When the disease stage increases in individuals with COPD, muscle oxygen utilization metabolism during submaximal exercise worsens, demanding more oxygen to the muscle to produce the same movement as in individuals with a lower disease stage. This may be explained by the fact that energy metabolism and endurance are affected due to the decrease in the oxygen level of the muscle and its capacity to utilize the available oxygen with increasing disease severity.

Keywords

COPD, near infrared spectrometry, severity, submaximal test

Ethical Statement

This study was approved by Bandırma Onyedi Eylul University Health Sciences Non-Interventional Research Ethics Committee (Ethics Committee No: 2023-72) and registered at ClinicalTrials.gov (Identifier: NCT06041126). The study was conducted according to the principles of the Declaration of Helsinki. Informed Consent: All patients signed the free and informed consent form.

Supporting Institution

None

Thanks

As the authors, we would like to thank the Assoc. Prof. Dilber Durmaz, pulmonologist at the department of pulmonology Bandırma Training and Research Hospital, who supported our data collection.

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