Relationship between coronary artery disease and high-density lipoprotein cholesterol-monocyte ratio

Abstract

Aims: To investigate the association between high-density lipoprotein cholesterol (HDL-C)-to- monocyte ratio(HMR) and coronary artery disease (CAD) proven by coronary angiography. Methods: A total of 311 patients were enrolled in the retrospective study. The grouping was based on whether the stenosis of one coronary artery exceeds 50%. Gensini Score (GS) to evaluate the severity of coronary artery stenosis. Spearman correlation analysis, progressive logistic regression, and receiver operating characteristic (ROC) curve analysis were used. Results: The HMR difference between the CAD and non-CAD groups was statistically significant (P<0.001). Spearman correlation analysis showed that the HMR was slightly and moderately correlated with other independent risk factors of CAD (r<0.5). HMR was a new independent risk factor by progressive logistic regression analysis (odds ratio=0.784. 95% CI, 0.682-0.901). HMR was related to the GS of CAD patients (r=-0.244, P<0.001). Moreover, the HMR was better than HDL-C and HDL-C-to-cholesterol by comparing AUC (AUC HDL-C-to-monocyte=0.642, AUC HDL-C=0.603, AUC HDL-C-to-cholesterol=0.584). Conclusion: HMR was an independent factor of CAD and can be used as a biomarker to evaluate the severity of CAD.

Keywords

• Coronary artery disease
• HDL-C-to-monocyte ratio
• coronary angiography

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