Aims: The aim of this study was to investigate peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD) at rest, during submaximal exercise, and during recovery, and to determine the effects of disease stage on peripheral muscle oxygenation.
Methods: Of the 35 stable COPD patients (62.49±8.45 years), 18 patients in GOLD 1 and 2 were assigned to Group 1 and 17 patients in GOLD 3 and 4 were assigned to Group 2. Dyspnea perception of the patients was evaluated with the Modified Medical Research Council (mMRC) Dyspnea Scale, severity of the disease affecting daily life was evaluated with the COPD Assessment Test (CAT-COPD Assessment Test), respiratory function was evaluated with the Pulmonary Function Test, and quadriceps muscle strength was evaluated with a manual muscle testing device. Muscle oxygenation of the patients was measured with Near-infrared spectroscopy (NIRS) for 5 minutes at rest, 6 minutes during the 6-Minute Walk Test (6-MWT), and 5 minutes during recovery after the end of the test. The results of the two groups were compared.
Results: Intragroup comparisons of muscle oxygenation at rest, during 6-MWT and during recovery; in Group 1, there was a statistically significant decrease between resting SmO2 mean and test SmO2 mean (p=0.001), a increase between test SmO2 mean and recovery SmO2 mean (p<0.001), and a significant increase between resting SmO2 mean and recovery SmO2 mean (p=0.022). In Group 2, there was a statistically significant decrease between resting SmO2 mean and SmO2 mean during the test (p=0.002), increase between resting SmO2 mean and recovery SmO2 mean (p<0.001*), and resting SmO2 mean and recovery SmO2 mean (p=0.024). There was no significant difference between the groups in Δ Rest-Test SmO2mean, Δ Recovery-Test SmO2mean, and Δ Recovery-Rest SmO2mean (p>0.05). In the SmO2 comparison of Group 1 and Group 2 at rest, during 6-MWT, and during recovery, it was observed that the test SmO2mean value was statistically higher in Group 2 (p=0.023).
Conclusion: When the disease stage increases in individuals with COPD, muscle oxygen utilization metabolism during submaximal exercise worsens, demanding more oxygen to the muscle to produce the same movement as in individuals with a lower disease stage. This may be explained by the fact that energy metabolism and endurance are affected due to the decrease in the oxygen level of the muscle and its capacity to utilize the available oxygen with increasing disease severity.
This study was approved by Bandırma Onyedi Eylul University Health Sciences Non-Interventional Research Ethics Committee (Ethics Committee No: 2023-72) and registered at ClinicalTrials.gov (Identifier: NCT06041126). The study was conducted according to the principles of the Declaration of Helsinki. Informed Consent: All patients signed the free and informed consent form.
None
As the authors, we would like to thank the Assoc. Prof. Dilber Durmaz, pulmonologist at the department of pulmonology Bandırma Training and Research Hospital, who supported our data collection.
Primary Language | English |
---|---|
Subjects | Chest Diseases, Physiotherapy |
Journal Section | Research Articles |
Authors | |
Publication Date | October 27, 2023 |
Published in Issue | Year 2023 Volume: 5 Issue: 4 |
TR DİZİN ULAKBİM and International Indexes (1b)
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]
Note: Our journal is not WOS indexed and therefore is not classified as Q.
You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/3449/file/4924/show
Journal Indexes and Platforms:
TR Dizin ULAKBİM, Google Scholar, Crossref, Worldcat (OCLC), DRJI, EuroPub, OpenAIRE, Turkiye Citation Index, Turk Medline, ROAD, ICI World of Journal's, Index Copernicus, ASOS Index, General Impact Factor, Scilit.The indexes of the journal's are;
The platforms of the journal's are;
The indexes/platforms of the journal are;
TR Dizin Ulakbim, Crossref (DOI), Google Scholar, EuroPub, Directory of Research Journal İndexing (DRJI), Worldcat (OCLC), OpenAIRE, ASOS Index, ROAD, Turkiye Citation Index, ICI World of Journal's, Index Copernicus, Turk Medline, General Impact Factor, Scilit
EBSCO, DOAJ, OAJI is under evaluation.
Journal articles are evaluated as "Double-Blind Peer Review"