Aims: The current study aimed to examine the values of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) in generalized anxiety disorder (GAD).
Methods: In this retrospective study, 147 GAD patients who did not receive treatment and 154 healthy controls with similar characteristics to the patient group were included. NLR, PLR, MLR, SII, and SIRI values calculated from the complete blood count values of the GAD group were compared with age- and sex-matched healthy controls.
Results: Neutrophil, lymphocyte, monocyte, platelet counts and NLR, MLR, SII, and SIRI values were significantly higher in the GAD group compared to healthy controls (p<0.001, p=0.001, p<0.001, p<0.001, p<0.001, p=0.003, p<0.001, p<0.001, respectively). The logistic regression analysis revealed that SII and SIRI were identified as significant variables associated with receiving a diagnosis of GAD.
Conclusion: Inflammatory markers such as NLR, MLR, SII, and SIRI are thought to play an important role in the evaluation of inflammatory activity in GAD. However, larger and more comprehensive studies are needed.
Generalized anxiety disorder inflammatory biomarker systemic immune-inflammation index systemic inflammatory response index
Primary Language | English |
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Subjects | Psychiatry |
Journal Section | Research Articles |
Authors | |
Publication Date | March 8, 2024 |
Submission Date | January 29, 2024 |
Acceptance Date | February 18, 2024 |
Published in Issue | Year 2024 Volume: 6 Issue: 2 |
TR DİZİN ULAKBİM and International Indexes (1b)
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]
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