Termination of pregnancy for fetal anomaly: evaluation of single centre results

Year 2024, Volume: 6 Issue: 6, 351 - 354, 28.10.2024

Masum Kayapınar , Zafer Bütün , Ece Akça Salık

https://doi.org/10.38053/acmj.1545553

Abstract

Aims: To assess the indications of termination of pregnancies (TOP) for fetal anomaly beyond 22 weeks of gestation.
Methods: It is a retrospective study conducted at Eskişehir City Hospital between January 2021 and December 2023. Our hospital which It serves as a tertiary referral center in the city. During the research period, 4143 births took place, and 495 women were treated in our high-risk unit. During the study period, 34 women underwent elective TOP at at least 22 weeks’ gestation. Routine 18–20-week anomaly screening was recommended for all pregnant women.
Results: The sonographic findings revealed the presence of 15 cases of central nervous system malformation, 4 cases of micromelia and thorax hypoplasia, 1 case of diafragma hernia, 3 case of early IUGG, 2 cases of cardiac anomaly, 2 cases of neural tube defect, 3 cases of isolated thorax hypoplasia, 1 case of scoliosis, 1 case of renal agenesis, 1 case of thick nuchal fold, 1 case of partial corpus collosum agenesis. Among 34 cases, there were 1 case of mosaic trisomy 21, case of trisomy 21, 1 case of trisomy 1, 3 cases of trisomy 13, 2 cases of trisomy 18. Array analysis revealed a case of 14 p deletion, 1 case of 16 p 11.2 deletion, 1 case of 1p36 deletion. In all study population 5 cases underwent cesarean delivery. Majority of the terminations were achieved by misoprostol or cervical balloon application.
Conclusion: In conclusion, although late termination of pregnancy by fetocide procedure seems to be safe, earlier detection of fetal structural and chromosomal anomalies is mandatory.

Keywords

Fetosid, termination of pregnancy, fetal anomaly

Ethical Statement

This study was conducted in accordance with the principles of the Helsinki Declaration and approved by the Institutional Ethical Committee (Approval no:2023-62; date: 22/11/2023). Written informed consent was obtained from all participants.

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