Twenty years of research on total intravenous anesthesia (TIVA): bibliometric analysis and visual mapping with Web of Science data

Year 2025, Volume: 7 Issue: 2, 97 - 104, 21.03.2025

Turan Evran , Hüseyin Özçınar , İsmet Çopur

Abstract

Aims: This study aims to determine the leading articles, countries, institutions, authors, funding sources and scientific collaborations by examining the scientific literature related to total intravenous anesthesia (TIVA) using bibliometric methods. It also aims to reveal the thematic structure and research trends of the field using keyword analysis.
Methods: A total of 494 English-language articles published in the Web of Science Core Collection (WoSCC) database were examined. Publication trends were evaluated using citation analyses, co-citation networks, and keyword co-occurrence analyses. Bibliometrix and VOSviewer programs were used for the analyses. In addition, thematic trends and keyword evolution were analyzed with Sankey diagrams and trend analysis.
Results: In total, 494 articles and 195 journals from 54 countries were evaluated. The most productive countries are the USA, China and South Korea, while institutions such as the National Defense Medical Center and Tri-Service General Hospital have come to the fore. Wu ZF, Lai HC and Lee MS have been identified as the most prolific authors. Anesthesiology has been the most cited journal, while pediatric anesthesia has been the most prolific journal. Among the most frequently used keywords were propofol, TIVA and anesthesia. After 2019, it has been observed that the interest in areas such as cancer surgery and recovery issues has increased. The studies of Nimmo and Wu ZF have been among the important references highlighting the oncological and postoperative advantages of TIVA.
Conclusion: This bibliometric study examines the scientific studies in the field of TIVA between 2003 and 2023. During this time, the number of publications has increased, and the USA has come to the fore as the country with the highest number of publications and citations. China and South Korea, on the other hand, are following the United States. National Defense Medical Center and Tri Service General Hospital are the prominent institutions. The most active authors are Wu ZF, Lai HC and Lee MS; Wu ZF in particular is the leader in both the number of publications and citations. Anesthesiology is the most cited and pediatric anesthesia is the most active journal. After 2019, there has been an increasing interest in the topics of "obstructive sleep apnea," "recovery," and "cancer surgery". The Sankey diagram indicates that topics such as "rocuronium," "cerebral oxygen saturation" and "surgery" were more focused during this period.

Keywords

Total intravenous anesthesia, bibliometric analysis, TIVA, propofol, anesthesia, volatile free anesthesia

References

• Nimmo AF, Absalom AR, Bagshaw O, et al. Guidelines for the safe practice of total intravenous anaesthesia (TIVA): joint guidelines from the association of anaesthetists and the society for intravenous anaesthesia. Anaesthesia. 2019;74(2):211-224. doi:10.1111/anae.14428
• Irwin MG, Trinh T, Yao CL. Occupational exposure to anaesthetic gases: a role for TIVA. Expert Opin Drug Saf. 2009;8(4):473-483. doi:10.1517/ 14740330903003778
• Shui M, Xue Z, Miao X, Wei C, Wu A. Intravenous versus inhalational maintenance of anesthesia for quality of recovery in adult patients undergoing non-cardiac surgery: a systematic review with meta-analysis and trial sequential analysis. PLoS One. 2021;16(7):e0254271. doi:10.1371/journal.pone.0254271
• Anderson BJ, Bagshaw O. Practicalities of total intravenous anesthesia and target-controlled infusion in children. Anesthesiology. 2019;131(1): 164-185. doi:10.1097/ALN.0000000000002657
• Mani V, Morton NS. Overview of total intravenous anesthesia in children. Paediatr Anaesth. 2010;20(3):211-222. doi:10.1111/j.1460-9592.2009. 03112.x
• Gargiulo DA, Mitchell SJ, Sheridan J, et al. Microbiological contamination of drugs during their administration for anesthesia in the operating room. Anesthesiology. 2016;124(4):785-794. doi:10.1097/ALN.0000000000001041
• Marik PE. Propofol: therapeutic indications and side-effects. Curr Pharm Des. 2004;10(29):3639-3649. doi:10.2174/1381612043382846
• Jia L, Hou J, Zheng H, et al. Study of the rational dose of propofol in elderly patients under bispectral index monitoring during total intravenous anesthesia: a PRISMA-compliant systematic review. Medicine (Baltimore). 2020;99(5):e19043. doi:10.1097/MD.0000000000019043
• Iri R, Unal E. (2024). Bibliometric Analysis of Research (1980-2023). Ahi Evran Üniversitesi Sosyal Bilimler Enstitüsü Dergisi. 2024;10(2):386-403. doi:10.31592/aeusbed.1446738
• Yao L, Zhang L, Tai Y, et al. Visual analysis of obesity and hypothyroidism: a bibliometric analysis. Medicine. 2024;103(1):e36841. doi:10.1097/MD.0000000000036841
• Kokol P, Blažun Vošner H, Završnik J. Application of bibliometrics in medicine: a historical bibliometrics analysis. Health Info Libr J. 2021; 38(2):125-138. doi:10.1111/hir.12295
• Landoni G, Lomivorotov VV, Nigro Neto C, et al. Volatile anesthetics versus total ıntravenous anesthesia for cardiac surgery. N Engl J Med. 2019;380(13):1214-1225. doi:10.1056/NEJMoa1816476
• Yap A, Lopez-Olivo MA, Dubowitz J, Hiller J, Riedel B; Global Onco-Anesthesia Research Collaboration Group. Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia. Can J Anesth. 2019;66(8):1007-1008. doi: 10.1007/s12630-019-01381-0
• Wigmore TJ, Mohammed K, Jhanji S. Long-term survival for patients undergoing volatile versus IV anesthesia for cancer surgery: a retrospective analysis. Anesthesiology. 2016;124(1):69-79. doi:10.1097/ALN.0000000000000936
• Wu ZF, Lee MS, Wong CS, et al. Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in colon cancer surgery. Anesthesiology. 2018;129(5):932-941. doi:10. 1097/ALN.0000000000002357
• Kataria BK, Ved SA, Nicodemus HF, et al. The pharmacokinetics of propofol in children using three different data analysis approaches. Anesthesiology. 1994;80(1):104-122. doi:10.1097/00000542-199401000-00018
• McFarlan CS, Anderson BJ, Short TG. The use of propofol infusions in paediatric anaesthesia: a practical guide. Paediatr Anaesth. 1999;9(3): 209-216. doi:10.1046/j.1460-9592.1999.00364.x
• Ozek B, Lu Z, Pouromran F, Radhakrishnan S, Kamarthi S. Analysis of pain research literature through keyword co-occurrence networks. PLOS Digit Health. 2023;2(9):e0000331. doi:10.1371/journal.pdig.0000331
• Hao P, Xin R, Li Y, Na X, Lv X. Developmental trends and knowledge frameworks in the application of radiomics in prostate cancer: a bibliometric analysis from 2000 to 2024. Discov Oncol. 2024;15(1):781. doi:10.1007/s12672-024-01678-7
• Farhat F, Silva ES, Hassani H, et al. The scholarly footprint of ChatGPT: a bibliometric analysis of the early outbreak phase. Front Artif Intell. 2024;6:1270749. doi:10.3389/frai.2023.1270749
• Shiao CC, Wu JT, Chu YC, Tang YH, Huang L, Lai HY. Bibliometric analysis of the top 100 most-cited articles on video laryngoscope from 2011 to 2022. J Chin Med Assoc. 2023;86(10):902-910. doi:10.1097/JCMA. 0000000000000981