IS THERE A RELATION BETWEEN CHORION FRONDOSUM THICKNESS AND SEVERE HYPEREMESIS GRAVIDARUM?
Abstract
Background: Hyperemesis gravidarum (HG) is a pregnancy complication that is characterized by severe nausea, vomiting, weight loss, and dehydration. The current study investigated chorion frondosum (CF) thickness and the relation between placental dysfunction and hyperemesis gravidarum.
Methods: We enrolled 96 participants in this study during their first trimester of pregnancy. We found that 48 of them had hyperemesis gravidarum symptoms and +2/+3 urine ketone levels. The others were taken as controls. Demographic characteristics, blood β-hCG, thyroid hormone levels (TSH, fT3, fT4), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and urine ketone levels were obtained from all participants. The CF thickness of each participant was measured to demonstrate the relation between CF thickness and HG.
Results: The mean gestational age was 8.69 (± 2.15) weeks in the HG group and 8.92 (±2.14) weeks in the control group (p=0.6). The HG group had significantly higher urine ketone levels (+2.7) compared to the control group (+0.1) (p<0.001). The CF thickness was significantly higher in the HG group (16.02 mm) than in the control group (13.50 mm) (p=0.02).
Conclusion: The mean chorion frondosum thickness (CF) was significantly higher in the HG group than the healthy controls. This finding may also constitute clinical prediction, in addition to indicating pathophysiology.
Keywords
chorion, hyperemesis gravidarum, ultrasonography
Supporting Institution
No funding was used for the study.
Ethical Statement
The local ethics committee of Izmir Bakircay University approved the trial with 865 reference IDs. All procedures performed in the current study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Thanks
No acknowledgement for the study.
References
- Verberg MFG, Gillott DJ, Al-Fardan N, Grudzinskas JG. Hyperemesis gravidarum, a literature review. Hum Reprod Update. 2005 Oct;11(5):527–39.
- Roseboom TJ, Ravelli ACJ, van der Post JA, Painter RC. Maternal characteristics largely explain poor pregnancy outcome after hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2011 May;156(1):56–9.
- Veenendaal M, van Abeelen A, Painter R, van der Post J, Roseboom T. Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis. BJOG. 2011 Oct;118(11):1302–13.
- Kaufmann P, Black S, Huppertz B. Endovascular Trophoblast Invasion: Implications for the Pathogenesis of Intrauterine Growth Retardation and Preeclampsia. Biol Reprod. 2003 Jul;69(1):1–7.
- Dommisse J, Tiltman AJ. Placental bed biopsies in placental abruption. BJOG. 1992 Aug;99(8):651–4.
- Smith GCS, Fretts RC. Stillbirth. The Lancet. 2007;370(9600):1715–25.
- Chen JZJ, Sheehan PM, Brennecke SP, Keogh RJ. Vessel remodelling, pregnancy hormones and extravillous trophoblast function. Mol Cell Endocrinol. 2012;349(2):138–44.
- Ali AI, Nori W, Abdulrahman Hadi BAl. Hyperemesis gravidarum and risks of placental dysfunction disorders. J Pak Med Assoc. 2021 Dec 1;71 9)(12):S24–8.
- Niemeijer MN, Grooten IJ, Vos N, Bais JMJ, van der Post JA, Mol BW, et al. Diagnostic markers for hyperemesis gravidarum: A systematic review and metaanalysis. Am J Obstet Gynecol. 2014;211(2):150.e1-150.e15.
- Vandraas KF, Vikanes Å V, Støer NC, Vangen S, Magnus P, Grjibovski AM. Is hyperemesis gravidarum associated with placental weight and the placental weight-to-birth weight ratio? A population-based Norwegian cohort study. Placenta. 2013;34(11):990–4.