IS THERE A RELATION BETWEEN CHORION FRONDOSUM THICKNESS AND SEVERE HYPEREMESIS GRAVIDARUM?
Abstract
Background: Hyperemesis gravidarum (HG) is a pregnancy complication that is characterized by severe nausea, vomiting, weight loss, and dehydration. The current study investigated chorion frondosum (CF) thickness and the relation between placental dysfunction and hyperemesis gravidarum.
Methods: We enrolled 96 participants in this study during their first trimester of pregnancy. We found that 48 of them had hyperemesis gravidarum symptoms and +2/+3 urine ketone levels. The others were taken as controls. Demographic characteristics, blood β-hCG, thyroid hormone levels (TSH, fT3, fT4), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and urine ketone levels were obtained from all participants. The CF thickness of each participant was measured to demonstrate the relation between CF thickness and HG.
Results: The mean gestational age was 8.69 (± 2.15) weeks in the HG group and 8.92 (±2.14) weeks in the control group (p=0.6). The HG group had significantly higher urine ketone levels (+2.7) compared to the control group (+0.1) (p<0.001). The CF thickness was significantly higher in the HG group (16.02 mm) than in the control group (13.50 mm) (p=0.02).
Conclusion: The mean chorion frondosum thickness (CF) was significantly higher in the HG group than the healthy controls. This finding may also constitute clinical prediction, in addition to indicating pathophysiology.
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