The Relationship Between Systemic Inflammatory Response Index and Systemic Immune-Inflammation Index and Diagnostic Rates of Myocardial Infarction, Pulmonary Thromboembolism, and Aortic Dissection in Patients Presenting to the Emergency Department with Chest Pain
Abstract
Background: This study aims to investigate the association between the Systemic Inflammatory Response Index (SIRI) and the Systemic Immune-Inflammation Index (SII) and serious cardiovascular diagnoses such as myocardial infarction, pulmonary thromboembolism, and aortic dissection in patients presenting to the emergency department with chest pain. Additionally, it evaluates the potential role of these biomarkers in supporting clinical decision-making processes.
Methods: This retrospective cross-sectional study included 612 patients aged 18–100 years who presented with chest pain to the Emergency Department of Yozgat City Hospital between July 1, 2025, and July 31, 2025. Demographic characteristics, final diagnoses, and laboratory parameters were analyzed, and SII and SIRI values were calculated accordingly. Statistical analyses were conducted using SPSS 22 with appropriate statistical tests.
Results: In the STEMI group, the mean SII was 1725.90 ± 1274.25 and the mean SIRI was 4.50 ± 3.66. In the NSTEMI group, these values were 1410.94 ± 1341.51 and 3.28 ± 2.79, respectively. Patients with non-cardiovascular causes exhibited significantly lower SII and SIRI levels. Based on ROC analysis, the AUC for SII was 0.738 with a cut-off value of 658, while the AUC for SIRI was 0.723 with a cut-off of 1.92. A positive and significant correlation was found between SII/SIRI and troponin and D-dimer levels (p < 0.001).
Conclusion: SII and SIRI levels are markedly elevated in chest pain of cardiovascular origin and may serve as useful adjunct biomarkers in the diagnostic differentiation of these conditions.
Keywords
Chest Pain, Systemic Inflammatory Response Index (SIRI), Emergency Department Diagnostic Approach
Supporting Institution
None
Ethical Statement
All authors declare that the study was conducted in accordance with the Declaration of Hesinki and followed the ethical standards of Türkiye. Approval was granted by the Yozgat Bozok University Non-Interventional Clinical Research Ethics Committee (2025-GOKAEK- 2518_2025.15.10_687).
Thanks
None
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