The Relationship Between Systemic Inflammatory Response Index and Systemic Immune-Inflammation Index and Diagnostic Rates of Myocardial Infarction, Pulmonary Thromboembolism, and Aortic Dissection in Patients Presenting to the Emergency Department with Chest Pain
Öz
Background: This study aims to investigate the association between the Systemic Inflammatory Response Index (SIRI) and the Systemic Immune-Inflammation Index (SII) and serious cardiovascular diagnoses such as myocardial infarction, pulmonary thromboembolism, and aortic dissection in patients presenting to the emergency department with chest pain. Additionally, it evaluates the potential role of these biomarkers in supporting clinical decision-making processes.
Methods: This retrospective cross-sectional study included 612 patients aged 18–100 years who presented with chest pain to the Emergency Department of Yozgat City Hospital between July 1, 2025, and July 31, 2025. Demographic characteristics, final diagnoses, and laboratory parameters were analyzed, and SII and SIRI values were calculated accordingly. Statistical analyses were conducted using SPSS 22 with appropriate statistical tests.
Results: In the STEMI group, the mean SII was 1725.90 ± 1274.25 and the mean SIRI was 4.50 ± 3.66. In the NSTEMI group, these values were 1410.94 ± 1341.51 and 3.28 ± 2.79, respectively. Patients with non-cardiovascular causes exhibited significantly lower SII and SIRI levels. Based on ROC analysis, the AUC for SII was 0.738 with a cut-off value of 658, while the AUC for SIRI was 0.723 with a cut-off of 1.92. A positive and significant correlation was found between SII/SIRI and troponin and D-dimer levels (p < 0.001).
Conclusion: SII and SIRI levels are markedly elevated in chest pain of cardiovascular origin and may serve as useful adjunct biomarkers in the diagnostic differentiation of these conditions.
Anahtar Kelimeler
Chest Pain, Systemic Inflammatory Response Index (SIRI), Emergency Department Diagnostic Approach
Destekleyen Kurum
Yok
Etik Beyan
Yozgat Bozok Üniversitesi Girişimsel Olmayan Klinik Araştırmalar Etik Kurulu onayı 2025-GOKAEK-2518_2025.15.10_687
Teşekkür
Yok
Kaynakça
- Deniz L, Yuksel Y, Arslan HF, Aral H, Bulut U. Evaluation of systemic inflammation markers in predicting cardiac risk in patients with acute chest pain. Int J Med Biochem. 2023;6(2):75-83.
- Wang C, Yan W, Ren M, Zhong L. Screening significance of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) in coronary heart disease of symptomatic youth. Immun Inflamm Dis. 2024;12:e1369.
- Dziedzic EA, Gasior JS, Tuzimek A, Paleczny J, Junka A, Dabrowski M, et al. Investigation of the associations of novel inflammatory biomarkers—systemic inflammatory index (SII) and systemic inflammatory response index (SIRI)—with the severity of coronary artery disease and acute coronary syndrome occurrence. Int J Mol Sci. 2022;23(17):9553.
- Liu Z, Zheng L. Associations between SII, SIRI, and cardiovascular disease in obese individuals: a nationwide cross-sectional analysis. Front Cardiovasc Med. 2024;11:1361088.
- Bayraktar MF, Cosgun M. Can SII and SIRI predict the severity of coronary artery disease? Northwest Med J. 2024;4(3):157-62.
- Li Y, Bai G, Gao Y, Guo Z, Chen X, Liu T, et al. The systemic immune inflammatory response index can predict the clinical prognosis of patients with coronary artery disease. J Inflamm Res. 2023;16:5069-82.
- Guo J, Huang Y, Pang L, Yuan J, Zhou B, Fu M. Association of SIRI with ST segment elevation myocardial infarction and degree of coronary stenosis: a cross-sectional study. BMC Cardiovasc Disord. 2024;24(1):98.
- Xiu J, Lin X, Chen Q, Yu P, Lu J, Yang Y, et al. The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension. Front Cardiovasc Med. 2023;10:1163900.
- Can systemic inflammatory markers be used in pulmonary embolism risk assessment in acute pulmonary thromboembolism? J Inflamm Res. 2023;18:5969-77.
- Haba MSC, Manole OM, Buburuz AM, Tudorancea I, Costache-Enache II, Onofrei V. The prognostic value of inflammatory indices in acute pulmonary embolism. Diagnostics (Basel). 2025;15(3):312.