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Sulbactam+Cefoperazone in Treatment of Complicated Urinary Tract Infections

Year 1996, Volume: 1 Issue: 1, 35 - 36, 30.11.1996

Abstract



The
clinical efficacy and safety of sulbactam+cefoperazone combination was
evaluated 30 patients suffering from serious urinary tract infection,
complicated with urinary tract obstruction. All of the patients who were
operating lists, with proven urinary tract infection were given a total daily
dose of 2 gr sulbactam combined with 2 gr cefoperazone. Drug administration
continued for jive days intravenously twice daily. A 90 percent bacteriological
eradication of the isolates was achieved and no significant side effects.
Results of the bacteriological studies together with the clinical course of
patients confirmed excellent therapeutic efficacy and safety of this drug.

References

  • Kobayashi S, Arai S, Hayashi S, Sakaguchi T. In vitro effects of beta-lactams combined with beta-lactamase inhibitors against methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy. 1989:33(3);331-335. doi: ı0.ıı28/AAC.33.3.33ı
  • Williams JD. Importance of beta-lactamase and clinical implications of their inhibitors. Drugs. 1988;35:3-11.
  • Kawada Y. The significance of the combination of sulbactam and cefoperazone in the treatment of complicated urinary infections. Sulbactam: An Advance in Overcoming Bacterial Resistance. Science Press, Seul. 1986;66-70.
  • Kawada Y, Nishiura T. Clinical evaluation of cefoperazone/sulbactam in the surgical field. Sixth international Cefoperazone Symposium, Tokyo, 1982; p.69.
  • Gutmann L, Williamson R, Kitzis MD, Acar JF. Synergism and antagonism in double beta-lactam antibiotic combinations. The American journal of medicine. 1986;80(5C):21-29.
  • Kunii O. Clinical evaluation of sulbactam I cefoperazone in the field of internal medicine. Sixth International Cefoperazone Symposium, Tokyo.1982; p.61.
  • Uneo K. Bacteriological studies of sulbactam / cefoperazone. Sulbactam: An Advance in Overcaming Bacterial Resistance, Scince Press, 1986;25-27.
  • Fu KP, Neu J-JC. Synergistic activity of cefoperazone in combination with beta-lactamase inhibitors. J Antimicrob Chemother. 1981;7(3): 287-292. doi: ı0.ı093/jac/7.3.287
  • Sözer H. Urogenital infeksiyonlarda sefoperazon/ sulbaktam kombinasyonu. İlaç Tedavi Dergisi. 1994;7:32-33.
  • Yaman LS, Kandilci S, Gemalmaz H. Nonkomplike genitoüriner infeksiyonlann tedavisinde Sulperazone (sefoperazon + sulbaktam). İlaç ve Tedavi Dergisi. 1994;7:29-31.
  • Özyurt M, Yavaşcaoğlu İ, Şimşek Ü, Oktay B, Kavrama İ. Clinical experience with sulbactam / sefoperazone in complicated urinary tract infections. İlaç ve Tedavi Dergisi. 1994;7:34-36.
  • Reitberg DP, Marble DA, Schultz RW, et al. Pharmacokinetics of cefoperazone and sulbactam coadministered to subjects with normal renal function, patients with decreased renal function, and patients with end-stage renal disease on hemodialysis. Antimicrob Agents Che Mother. 1988; 32: 503-509.

Komplike Üriner Sistem İnfeksiyonlarinin Tedavisinde Sulbaktam+Sefoperazon

Year 1996, Volume: 1 Issue: 1, 35 - 36, 30.11.1996

Abstract





Sulbaktam
+ Sefoperazon kombinasyonunun etkinliği ve klinik güvenilirliği, üriner sistem
obstrüksiyonu ile komplike üriner sistem infeksiyonu bulunan 30 hastada
denendi. Hastalann tamamına operasyondan bir gün önce 2 gr sulbaktamla kombine
2 gr sefoperazon total günlük doz olarak başandı. Tedaviye daha sonra beş gün
süre ile aynı doz günde iki defada İV yolla verilerek devam edildi. İzole
edilen bakterilerde %90 oranında eradikasyon sağlanırken önemli bir yan etkiye
rastlanmadı. Sonuç olarak bakteriyolojik ve klinik veriler bu kombinasyonun
üriner sistem infeksiyonlarında etkili ve güvenilir olduğunu gösterdi.




References

  • Kobayashi S, Arai S, Hayashi S, Sakaguchi T. In vitro effects of beta-lactams combined with beta-lactamase inhibitors against methicillin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy. 1989:33(3);331-335. doi: ı0.ıı28/AAC.33.3.33ı
  • Williams JD. Importance of beta-lactamase and clinical implications of their inhibitors. Drugs. 1988;35:3-11.
  • Kawada Y. The significance of the combination of sulbactam and cefoperazone in the treatment of complicated urinary infections. Sulbactam: An Advance in Overcoming Bacterial Resistance. Science Press, Seul. 1986;66-70.
  • Kawada Y, Nishiura T. Clinical evaluation of cefoperazone/sulbactam in the surgical field. Sixth international Cefoperazone Symposium, Tokyo, 1982; p.69.
  • Gutmann L, Williamson R, Kitzis MD, Acar JF. Synergism and antagonism in double beta-lactam antibiotic combinations. The American journal of medicine. 1986;80(5C):21-29.
  • Kunii O. Clinical evaluation of sulbactam I cefoperazone in the field of internal medicine. Sixth International Cefoperazone Symposium, Tokyo.1982; p.61.
  • Uneo K. Bacteriological studies of sulbactam / cefoperazone. Sulbactam: An Advance in Overcaming Bacterial Resistance, Scince Press, 1986;25-27.
  • Fu KP, Neu J-JC. Synergistic activity of cefoperazone in combination with beta-lactamase inhibitors. J Antimicrob Chemother. 1981;7(3): 287-292. doi: ı0.ı093/jac/7.3.287
  • Sözer H. Urogenital infeksiyonlarda sefoperazon/ sulbaktam kombinasyonu. İlaç Tedavi Dergisi. 1994;7:32-33.
  • Yaman LS, Kandilci S, Gemalmaz H. Nonkomplike genitoüriner infeksiyonlann tedavisinde Sulperazone (sefoperazon + sulbaktam). İlaç ve Tedavi Dergisi. 1994;7:29-31.
  • Özyurt M, Yavaşcaoğlu İ, Şimşek Ü, Oktay B, Kavrama İ. Clinical experience with sulbactam / sefoperazone in complicated urinary tract infections. İlaç ve Tedavi Dergisi. 1994;7:34-36.
  • Reitberg DP, Marble DA, Schultz RW, et al. Pharmacokinetics of cefoperazone and sulbactam coadministered to subjects with normal renal function, patients with decreased renal function, and patients with end-stage renal disease on hemodialysis. Antimicrob Agents Che Mother. 1988; 32: 503-509.
There are 12 citations in total.

Details

Primary Language Turkish
Subjects Urology
Journal Section Research Articles
Authors

Orhan Yalçın This is me

Lütfü Tahmaz This is me

İdris Bilgiç This is me

Mustafa Yılmaz This is me

Publication Date November 30, 1996
Submission Date July 30, 1996
Acceptance Date November 1, 1996
Published in Issue Year 1996 Volume: 1 Issue: 1

Cite

AMA Yalçın O, Tahmaz L, Bilgiç İ, Yılmaz M. Komplike Üriner Sistem İnfeksiyonlarinin Tedavisinde Sulbaktam+Sefoperazon. Acta Med Nicomedia. November 1996;1(1):35-36.

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