Erken Gebelikte Progesteron Tedavisinin Hormonal ve Klinik Etkileri

Year 1997, Volume: 2 Issue: 1, 21 - 23, 30.01.1997

Aydın Çorakçı Semih Özeren İzzet Yücesoy Ramazan Mercan Gülseren Yücesoy Metin Çapar

Abstract

Çalışmamızda erken gebelikte tartışmalı bir konu
olan progesteron tedavisinin hormonal ve klinik etkilerini araştırıp
progesteron tedavisi uygulanacak hastaları seçmek için protokol geliştirmeyi
amaçladık. Düşük tehdidi bulguları ile başvuran 6-9 haftalık 48 gebe iki gruba
ayrıldı. Grup I'e tedavi verilmedi, grup II'ye 250 mg 17 OH progesteron
kapronat İM verildi. Bir hafta sonra progesteron, estradiol, hCG, ve 17 OH
progesteron değişiklikleri izlenerek 2 grup karşılaştırıldı. Grup I'de 24
hastanın 3'ünde (%12,5), grup II'de 24 hastanın 2'sinde (%8,33) düşük
gerçekleşti. Ancak hormonal değerler arasında anlamlı bir fark gözlenmedi.

Çalışmamızda elde ettiğimiz sonuçlara dayanarak
progesteronu 10 ng/ml'nin altında olan olası luteal faz defekti bulunan düşük
tehdidi bulguları gösteren hastalara ultrasonografi ile fetusun viabilitesi
tespit edildikten sonra progesteron tedavisinin yararlı olabileceği kanaatine
vardık.

Keywords

Erken gebelik, progesteron tedavisi, luteal faz defekti

Hormonal and Clinical Effects of Progesterone Therapy in Early Pregnancy

Abstract

The purpose of this study was to evaluate the
clinical and hormonal effects of progesterone treatment in early pregnancy and
to establish a protocol to determine the patients who would benefit from
progesterone treatment. 48 women who were admitted with the signs of threatened
abortion and had gestational ages ranged from 6 to 9 weeks were divided into
two groups. Group I did not receive any treatment while group II received 250
mg 17 OH Progesterone capronate intramuscularly. One week later, serum levels
of progesterone, estradiol, hCG, and 17 OH Progesterone were measured and the
results of each group were compared. Abortion occurred in 3 of 24 (12.5%) woman
in group I and 2 of 24 (8.33%) women in group II. No significant differences
between hormonal measurements were noted in both groups.

We conclude that after detecting fetal viability by
ultrasonography, progesterone treatment might be useful in patients with
threatened abortion who have a progesterone level less than 10 ng/ml and who
probably have a luteal phase defect.

Keywords

Early pregnancy, progesterone treatment, luteal phase defect

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