Hematolojik Kanser Olguları ve Kan Donörlerinde Sitomegalovirüs IgG ve IgM Antikorları
Year 1997,
Volume: 2 Issue: 2, 20 - 22, 30.04.1997
Erdener Balıkçı
Mehmet Orhan Ayyıldız
Naci Tiftik
Dede Şit
Ömer Mete
Abstract
Bu çalışmada 40 hematolojik kanser (15 Akut lenfoblastik lösemi, 14 Akut myeblastik lösemi, 8 Lenfoma ve 3 Multipl Myeloma) ve 35 gönüllü kan donöründe Sitomegalovirüs (CMV) antikorları ELISA ile çalışıldı. Hemotolojik hasta grubunda CMV IgG antikorları 26/40 hastada (%65), CMV IgM antikorları 3/40 hastada (%7,5) oranında pozitif bulundu. Rastgele seçilmiş sağlıklı kan donörlerinde bu oran CMV IgG’de 22/35 hastada (%62.8), CMV IgM için 1/35 hastada (%2.8) pozitif bulundu. Hematolojik hasta grubunda IgG ve IgM birlikteliğinde 6/40 (%15) oranında pozitiflik saptandı. Sonuçlar CMV’nin sık kan transfüzyonu yapılan hematolojik kanser hastalarındaki enfeksiyon ve reaktivasyonunun önemine işaret etmektedir
References
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Year 1997,
Volume: 2 Issue: 2, 20 - 22, 30.04.1997
Erdener Balıkçı
Mehmet Orhan Ayyıldız
Naci Tiftik
Dede Şit
Ömer Mete
References
- Schooley RT, Hirsch MS, Colvin RB et al. Association of herpesvirus infections with T-lymphocyte-subset alterations, glomerulopathy, and opportunistic infections after renal transplantation. N Engl J Med. 1983;308(6):307-313. doi:10.1056/NEJM198302103080603
- Jackson JB, Orr HT, McCullough JJ, Jordan MC. Failure to detect human cytomegalovirus DNA in IgM-seropositive blood donors by spot hybridization. J Infect Dis. 1987;156(6):1013-1016. doi: 10.1093/infdis/156.6.1013
- Nielsen SL, Sørensen I, Andersen HK. Kinetics of specific immunoglobulins M, E, A, and G in congenital, primary, and secondary cytomegalovirus infection studied by antibody-capture enzyme-linked immunosorbent assay. J Clin Microbiol. 1988;26(4):654–661.
- Abott laboratories. Human cytomegalovirus. Wiesbaden. 1987.
- Schimpff SC. Infections in compromised host. An overview. In: Mandell GL, Douglas RG, Bennet JE, eds. Principles and practice of infections diseases. USA: Churchill Livingstone; 1990.
- Casazza AR, Charles PD, Carbone PP. Infection in Lymphoma Histology, Treatment, and Duration in Relation to Incidence and Survival. JAMA. 1966;197(9):710-716. doi:10.1001/jama.1966.03110090074021
- Cangir A, Sullivan MP. The Occurrence of Cytomegalovirus Infections in Childhood Leukemia. Report of Three Cases. JAMA. 1966;195(8):616-622. doi:10.1001/jama.1966.03100080056015
- Beresford CH, Storey G, Faed JM, Milligan LM. Cytomegalovirus infection and blood transfusion. N Z Med J. 1988 J;101(838):2-4.
- Ho M. Epidemiology of cytomegalovirus infections. Rev Infect Dis. 1990;12:701-710. doi: 10.1093/clinids/12.supplement_7.s701
- Onorato IM, Morens DM, Martone WJ, Stansfield SK. Epidemiology of cytomegaloviral infections: recommendations for prevention and control. Rev Infect Dis. 1985;7(4):479-497. doi:10.1093/clinids/7.4.479
- Pass RF. Epidemiology and transmission of cytomegalovirus. J Infect Dis. 1985;152(2):243-248. doi: 10.1093/infdis/152.2.243
- Kılıç S. Kan ve kan ürünleriyle bulaşan enfeksiyonlar. 3.Ulusal enfeksiyon hastalıkları kongre kitabı. 1991; İzmir.
- Lentz EB, Dock NL, McMahon CA, Fiesthumel SR, Arnold CB, Lamberson HV Jr. Detection of antibody to cytomegalovirus-induced early antigens and comparison with four serologic assays and presence of viruria in blood donors. J Clin Microbiol. 1988;26(1):133-135.
- Cox F, Hughes WT. The value of isolation procedures for cytomegalovirus infections in children with leukemia. Cancer. 1975;36(3):1158-61. doi:10.1002/1097-0142(197509)36:3<1158::aid-cncr2820360350>3.0.co;2-n
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- Erkişi, Yarkın F, Öztürk C, Hafta A, Akın O, Akan E. A study of cytomegalovirus(CMV) and Epstein-Barr virus(EBV) IgM antibodies in lung and breast cancer patients. . İnfeksiyon dergisi (Turkish Journal of Infection). 1993;7(3-4):235-237.