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İdiyopatik Erkek Faktör İnfertilitesi Tanısıyla ICSI Yapılan Hastalarda Antioksidan Tedavinin Fertilizasyon, Gebelik ve Canlı Doğum Oranlarına Etkisi

Year 2021, Volume: 4 Issue: 2, 35 - 39, 30.06.2021

Abstract

AMAÇ :
Çalışmamızda idiyopatik erkek faktör infertilitesi (erkek subfertilitesi) nedeniyle ICSI uygulanan çiftlerde öncesinde kombine antioksidan kullanımının fertilizasyon, gebelik ve canlı doğum oranlarına etkisini araştırmayı amaçladık.
YÖNTEM:
2008-2010 yılları arasında Kocaeli Üniversitesi Üroloji Anabilim Dalı Androloji Polikliniğinde idiyopatik erkek faktör infertilitesi (erkek subfertilitesi) tanısı alan ve Kocaeli Üniversitesi Yardımla Üreme Teknikleri Merkezinde ICSI tedavisi uygulanan hastalar geriye dönük olarak değerlendirildi. Bunlardan bilgilerine ulaşılabilen oligoastenospermisi olan, eşlik eden kadın faktörü olmayan ve spontan gebelik olmayan 55 hasta çalışmaya dahil edildi. Bu hastalar medikal tedavi almayan (n=31) ve günde iki kez Proxeed plus® tedavisi alan (n=24) olarak gruplandı. Semen parametrelerinde değişim ve fertilizasyon, gebelik ve canlı doğum oranları karşılaştırıldı.
BULGULAR:
Her iki grupta, kadın ve erkek hasta yaşları, başlangıç ve ICSI öncesi sperm sayı ve hareketleri benzerdi (p>0,05). Her iki grupta enjeksiyon yapılan oosit sayısı, fertilize olan oosit sayısı ve fertilizasyon oranları benzerdi (p>0,05). Her iki grupta gebelik ve canlı doğum oranlarında fark saptanmadı (p>0,05). Tedavi alan grupta ICSI öncesi sperm sayısındaki artış anlamlı değildi (p>0,05) ve sperm hareketi %50’ nin altında olanların oranı değişmemişti (p=1,000).
SONUÇ:
İdiyopatik erkek faktör infertilitesi nedeniyle ICSI yapılan hastalarda kombine antioksidan kullanımı ile semen parametrelerinde ve fertilizasyon, gebelik, canlı doğum oranlarında anlamlı iyileşme izlenmedi. Bulgularımızın daha iyi değerlendirilebilmesi için plasebo kontrollü ileri dönük rastgele hasta seçimi yapılmış çalışmalara ihtiyaç vardır.

References

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  • 2. Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Human reproduction. May 2005;20(5):1144-7. doi:10.1093/humrep/deh870
  • 3. Evers JL. Female subfertility. Lancet. Jul 13 2002;360(9327):151-9. doi:10.1016/S0140-6736(02)09417-5
  • 4. Siddiq FM, Sigman M. A new look at the medical management of infertility. The Urologic clinics of North America. Nov 2002;29(4):949-63. doi:10.1016/s0094-0143(02)00085-x
  • 5. Irvine DS. Epidemiology and aetiology of male infertility. Human reproduction. Apr 1998;13 Suppl 1:33-44. doi:10.1093/humrep/13.suppl_1.33
  • 6. Winters BR, Walsh TJ. The epidemiology of male infertility. The Urologic clinics of North America. Feb 2014;41(1):195-204. doi:10.1016/j.ucl.2013.08.006
  • 7. De Geyter C, Calhaz-Jorge C, Kupka MS, et al. ART in Europe, 2015: results generated from European registries by ESHRE. Human reproduction open. 2020;2020(1):hoz038. doi:10.1093/hropen/hoz038
  • 8. Aitken RJ, Buckingham D, West K, Wu FC, Zikopoulos K, Richardson DW. Differential contribution of leucocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors. Journal of reproduction and fertility. Mar 1992;94(2):451-62. doi:10.1530/jrf.0.0940451
  • 9. Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. Journal of reproduction and fertility. Nov 1987;81(2):459-69. doi:10.1530/jrf.0.0810459
  • 10. Aitken RJ, Clarkson JS, Hargreave TB, Irvine DS, Wu FC. Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. Journal of andrology. May-Jun 1989;10(3):214-20. doi:10.1002/j.1939-4640.1989.tb00091.x
  • 11. Iwasaki A, Gagnon C. Formation of reactive oxygen species in spermatozoa of infertile patients. Fertility and sterility. Feb 1992;57(2):409-16. doi:10.1016/s0015-0282(16)54855-9
  • 12. Mazzilli F, Rossi T, Marchesini M, Ronconi C, Dondero F. Superoxide anion in human semen related to seminal parameters and clinical aspects. Fertility and sterility. Oct 1994;62(4):862-8. doi:10.1016/s0015-0282(16)57017-4
  • 13. Shekarriz M, Thomas AJ, Jr., Agarwal A. Incidence and level of seminal reactive oxygen species in normal men. Urology. Jan 1995;45(1):103-7. doi:10.1016/s0090-4295(95)97088-6
  • 14. Zini A, de Lamirande E, Gagnon C. Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase- and catalase-like activities in seminal plasma and spermatozoa. International journal of andrology. Jun 1993;16(3):183-8. doi:10.1111/j.1365-2605.1993.tb01177.x
  • 15. Shimura T, Inoue M, Taga M, et al. p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm. Molecular and cellular biology. Apr 2002;22(7):2220-8. doi:10.1128/mcb.22.7.2220-2228.2002
  • 16. Robinson L, Gallos ID, Conner SJ, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Human reproduction. Oct 2012;27(10):2908-17. doi:10.1093/humrep/des261
  • 17. Simon L, Murphy K, Shamsi MB, et al. Paternal influence of sperm DNA integrity on early embryonic development. Human reproduction. Nov 2014;29(11):2402-12. doi:10.1093/humrep/deu228
  • 18. Smits RM, Mackenzie-Proctor R, Yazdani A, Stankiewicz MT, Jordan V, Showell MG. Antioxidants for male subfertility. The Cochrane database of systematic reviews. Mar 14 2019;3:CD007411. doi:10.1002/14651858.CD007411.pub4
  • 19. WHO. WHO Laboratory Manual for The Examination of Human Semen and Semen-Cervical Mucus Interaction Cambridge University Press; 1999:126.
  • 20. Guzick DS, Overstreet JW, Factor-Litvak P, et al. Sperm morphology, motility, and concentration in fertile and infertile men. The New England journal of medicine. Nov 8 2001;345(19):1388-93. doi:10.1056/NEJMoa003005
  • 21. Kessopoulou E, Powers HJ, Sharma KK, et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertility and sterility. Oct 1995;64(4):825-31. doi:10.1016/s0015-0282(16)57861-3
  • 22. Greco E, Romano S, Iacobelli M, et al. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Human reproduction. Sep 2005;20(9):2590-4. doi:10.1093/humrep/dei091
  • 23. Tremellen K, Miari G, Froiland D, Thompson J. A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. The Australian & New Zealand journal of obstetrics & gynaecology. Jun 2007;47(3):216-21. doi:10.1111/j.1479-828X.2007.00723.x
  • 24. Tremellen K, Woodman R, Hill A, Shehadeh H, Lane M, Zander-Fox D. Use of a male antioxidant nutraceutical is associated with superior live birth rates during IVF treatment. Asian journal of andrology. Jan-Feb 2021;23(1):16-23. doi:10.4103/aja.aja_41_20
  • 25. Joseph T, Mascarenhas M, Karuppusami R, Karthikeyan M, Kunjummen AT, Kamath MS. Antioxidant pretreatment for male partner before ART for male factor subfertility: a randomized controlled trial. Human reproduction open. 2020;2020(4):hoaa050. doi:10.1093/hropen/hoaa050
  • 26. Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. The Cochrane database of systematic reviews. Jan 19 2011;(1):CD007411. doi:10.1002/14651858.CD007411.pub2
  • 27. Showell MG, Mackenzie-Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. The Cochrane database of systematic reviews. 2014;(12):CD007411. doi:10.1002/14651858.CD007411.pub3
  • 28. Steiner AZ, Hansen KR, Barnhart KT, et al. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertility and sterility. Mar 2020;113(3):552-560 e3. doi:10.1016/j.fertnstert.2019.11.008
Year 2021, Volume: 4 Issue: 2, 35 - 39, 30.06.2021

Abstract

References

  • 1. Zegers-Hochschild F, Adamson GD, Dyer S, et al. The International Glossary on Infertility and Fertility Care, 2017. Fertility and sterility. Sep 2017;108(3):393-406. doi:10.1016/j.fertnstert.2017.06.005
  • 2. Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Human reproduction. May 2005;20(5):1144-7. doi:10.1093/humrep/deh870
  • 3. Evers JL. Female subfertility. Lancet. Jul 13 2002;360(9327):151-9. doi:10.1016/S0140-6736(02)09417-5
  • 4. Siddiq FM, Sigman M. A new look at the medical management of infertility. The Urologic clinics of North America. Nov 2002;29(4):949-63. doi:10.1016/s0094-0143(02)00085-x
  • 5. Irvine DS. Epidemiology and aetiology of male infertility. Human reproduction. Apr 1998;13 Suppl 1:33-44. doi:10.1093/humrep/13.suppl_1.33
  • 6. Winters BR, Walsh TJ. The epidemiology of male infertility. The Urologic clinics of North America. Feb 2014;41(1):195-204. doi:10.1016/j.ucl.2013.08.006
  • 7. De Geyter C, Calhaz-Jorge C, Kupka MS, et al. ART in Europe, 2015: results generated from European registries by ESHRE. Human reproduction open. 2020;2020(1):hoz038. doi:10.1093/hropen/hoz038
  • 8. Aitken RJ, Buckingham D, West K, Wu FC, Zikopoulos K, Richardson DW. Differential contribution of leucocytes and spermatozoa to the generation of reactive oxygen species in the ejaculates of oligozoospermic patients and fertile donors. Journal of reproduction and fertility. Mar 1992;94(2):451-62. doi:10.1530/jrf.0.0940451
  • 9. Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. Journal of reproduction and fertility. Nov 1987;81(2):459-69. doi:10.1530/jrf.0.0810459
  • 10. Aitken RJ, Clarkson JS, Hargreave TB, Irvine DS, Wu FC. Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. Journal of andrology. May-Jun 1989;10(3):214-20. doi:10.1002/j.1939-4640.1989.tb00091.x
  • 11. Iwasaki A, Gagnon C. Formation of reactive oxygen species in spermatozoa of infertile patients. Fertility and sterility. Feb 1992;57(2):409-16. doi:10.1016/s0015-0282(16)54855-9
  • 12. Mazzilli F, Rossi T, Marchesini M, Ronconi C, Dondero F. Superoxide anion in human semen related to seminal parameters and clinical aspects. Fertility and sterility. Oct 1994;62(4):862-8. doi:10.1016/s0015-0282(16)57017-4
  • 13. Shekarriz M, Thomas AJ, Jr., Agarwal A. Incidence and level of seminal reactive oxygen species in normal men. Urology. Jan 1995;45(1):103-7. doi:10.1016/s0090-4295(95)97088-6
  • 14. Zini A, de Lamirande E, Gagnon C. Reactive oxygen species in semen of infertile patients: levels of superoxide dismutase- and catalase-like activities in seminal plasma and spermatozoa. International journal of andrology. Jun 1993;16(3):183-8. doi:10.1111/j.1365-2605.1993.tb01177.x
  • 15. Shimura T, Inoue M, Taga M, et al. p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm. Molecular and cellular biology. Apr 2002;22(7):2220-8. doi:10.1128/mcb.22.7.2220-2228.2002
  • 16. Robinson L, Gallos ID, Conner SJ, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis. Human reproduction. Oct 2012;27(10):2908-17. doi:10.1093/humrep/des261
  • 17. Simon L, Murphy K, Shamsi MB, et al. Paternal influence of sperm DNA integrity on early embryonic development. Human reproduction. Nov 2014;29(11):2402-12. doi:10.1093/humrep/deu228
  • 18. Smits RM, Mackenzie-Proctor R, Yazdani A, Stankiewicz MT, Jordan V, Showell MG. Antioxidants for male subfertility. The Cochrane database of systematic reviews. Mar 14 2019;3:CD007411. doi:10.1002/14651858.CD007411.pub4
  • 19. WHO. WHO Laboratory Manual for The Examination of Human Semen and Semen-Cervical Mucus Interaction Cambridge University Press; 1999:126.
  • 20. Guzick DS, Overstreet JW, Factor-Litvak P, et al. Sperm morphology, motility, and concentration in fertile and infertile men. The New England journal of medicine. Nov 8 2001;345(19):1388-93. doi:10.1056/NEJMoa003005
  • 21. Kessopoulou E, Powers HJ, Sharma KK, et al. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertility and sterility. Oct 1995;64(4):825-31. doi:10.1016/s0015-0282(16)57861-3
  • 22. Greco E, Romano S, Iacobelli M, et al. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Human reproduction. Sep 2005;20(9):2590-4. doi:10.1093/humrep/dei091
  • 23. Tremellen K, Miari G, Froiland D, Thompson J. A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment. The Australian & New Zealand journal of obstetrics & gynaecology. Jun 2007;47(3):216-21. doi:10.1111/j.1479-828X.2007.00723.x
  • 24. Tremellen K, Woodman R, Hill A, Shehadeh H, Lane M, Zander-Fox D. Use of a male antioxidant nutraceutical is associated with superior live birth rates during IVF treatment. Asian journal of andrology. Jan-Feb 2021;23(1):16-23. doi:10.4103/aja.aja_41_20
  • 25. Joseph T, Mascarenhas M, Karuppusami R, Karthikeyan M, Kunjummen AT, Kamath MS. Antioxidant pretreatment for male partner before ART for male factor subfertility: a randomized controlled trial. Human reproduction open. 2020;2020(4):hoaa050. doi:10.1093/hropen/hoaa050
  • 26. Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. The Cochrane database of systematic reviews. Jan 19 2011;(1):CD007411. doi:10.1002/14651858.CD007411.pub2
  • 27. Showell MG, Mackenzie-Proctor R, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. The Cochrane database of systematic reviews. 2014;(12):CD007411. doi:10.1002/14651858.CD007411.pub3
  • 28. Steiner AZ, Hansen KR, Barnhart KT, et al. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertility and sterility. Mar 2020;113(3):552-560 e3. doi:10.1016/j.fertnstert.2019.11.008
There are 28 citations in total.

Details

Primary Language Turkish
Subjects Urology
Journal Section Research Articles
Authors

Hasan Yılmaz 0000-0003-2512-8820

Mustafa Melih Çulha 0000-0002-7617-7529

Publication Date June 30, 2021
Submission Date May 20, 2021
Acceptance Date June 4, 2021
Published in Issue Year 2021 Volume: 4 Issue: 2

Cite

AMA Yılmaz H, Çulha MM. İdiyopatik Erkek Faktör İnfertilitesi Tanısıyla ICSI Yapılan Hastalarda Antioksidan Tedavinin Fertilizasyon, Gebelik ve Canlı Doğum Oranlarına Etkisi. Acta Med Nicomedia. June 2021;4(2):35-39. doi:10.53446/actamednicomedia.939839

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