Çocukluk çağı vasküliti ile takipli hastaların demografik verileri ve klinik izlemleri

Year 2024, Volume: 7 Issue: 2, 214 - 218, 30.06.2024

Kübra Uçak Nihal Şahin Hafize Emine Sönmez

Abstract

Giriş:
Vaskülitler, damar duvarlarının iltihaplanmasıyla karakterize bir grup hastalıktır. Vaskülitlerin çoğu belli büyüklükteki damarlarda inflamasyon yapar ve belirli hedef organlarda tutulum yaparlar. Bu çalışmada kliniğimizde vaskülit tanısı almış çocuk hastaların verilerini inceleyerek bölgemizdeki çocuk hekimlerinin bu konuda farkındalığını arttırmayı amaçladık.
Yöntem:
Çalışmada vaskülit tanısı alan 0-18 yaş arası hastalar incelendi. Vaskülit alt grupları, hastaların demografik verileri klinik bulguları ve tanı anındaki laboratuvar bulguları geriye dönük olarak tarandı.
Bulgular:
Çalışmaya dahil edilen 95 hastadan 78’i (%83) Henoch-Schönlein purpurası/Immunoglobulin A vasküliti (HSP/IgAV), 8’i (%8,4) Kawasaki hastalığı (KH), 6’sı (%6,4) Behçet Hastalığı (BH), 1’i (%1,1) eozinofilik granülomatöz polianjiyit/Churg-Strauss sendromu ve 1’i (%1,1) de santral sinir sistemi (SSS) vasküliti tanısı aldı. Yaş aralıklarına göre dağılımına bakıldığında; KH bebeklik ve oyun çocuğu döneminde daha sıkken BH sıklığı ergenlik döneminde artmaktaydı. Ancak HSP/IgAV bebeklik dönemi hariç her yaş grubunda en sık görülen vaskülit türüydü.
Sonuç:
Çocukluk çağı vaskülitleri klinik olarak tanınması oldukça güçtür ve bu konuda yapılmış epidemiyolojik çalışmalar oldukça yetersizdir. Sonuçlarımız bu hastalarla günlük pratiğinde karşılaşan çocuk hekimlerinin farkındalığı arıtmaya yardımcı olabilir.

Keywords

Henoch-Schönlein purpurası/Immunoglobulin A vasküliti, Kawasaki hastalığı, Vaskülit

Ethical Statement

Kocaeli Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurulu onayı alınmıştır. Tüm prosedürler, kurumsal ve/veya ulusal araştırma komitesinin etik standartlarına ve 1964 Helsinki Bildirgesi’ne uygun olarak gerçekleştirilmiştir. (Onay numarası ve tarihi: GOKAEK-2023/11.20, 16.Haziran.2023).

Supporting Institution

yok

Demographic data and clinical follow-up of patients with childhood vasculitis

Abstract

Objective
Vasculitides are distinguished by the inflammation of blood vessel walls. These conditions affect vessels of particular sizes and specific target organs. Herein, we aimed to increase the awareness of pediatricians concerning vasculitides by conducting a retrospective analysis of patients.
Methods
We conducted an examination of individuals aged 0-18 years who had been diagnosed with vasculitis. Subgroups of vasculitis, demographic, clinical, and laboratory findings of patients were reviewed retrospectively.
Results
Among the 95 patients included in the study, Henoch-Schönlein purpura/Immunoglobulin A vasculitis (HSP/IgAV) was the predominant vasculitis, afflicting 78 (83%) of the patients. Kawasaki disease (KD) was identified in 8 patients (8.4%), while Behçet's Disease (BD) was diagnosed in 6 (6.4%). One patient (1.1%) presented with eosinophilic granulomatosis polyangiitis/Churg-Strauss syndrome. One patient (1.1%) was diagnosed with central nervous system vasculitis. In terms of age distribution, KD was more prevalent in infancy and early childhood while the incidence of BD rises during adolescence. However, HSP/IgAV emerged as the most common vasculitis type across all age groups, except for infancy.
Conclusion
The clinical diagnosis of vasculitis in children can be particularly challenging. Moreover, there is a notable lack of comprehensive epidemiological studies in this area. The outcomes of our study have the potential to augment the awareness of pediatricians who routinely care for children with vasculitis in their clinical practice.

Keywords

Henoch-Schönlein purpura/Immunoglobulin A vasculitis, Kawasaki disease, Vasculitis

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