Evaluation of Insulin Resistance and Metabolic Syndrome Components in Patients with Seborrheic Dermatitis

Year 2024, Volume: 7 Issue: 3, 283 - 287, 27.10.2024

Rabia Öztaş Kara , Bahar Sevimli Dikicier , Berna Solak , Büşra Aydın

https://doi.org/10.53446/actamednicomedia.1457017

Abstract

Objective: Seborrheic dermatitis (SD) is a common inflammatory skin disorder. There is scarce data regarding SD and metabolic syndrome. We aimed to investigate the prevalence of metabolic syndrome in patients with seborrheic dermatitis.
Methods: Sixty-six patients with seborrheic dermatitis and 52 healthy controls were enrolled. Subjects’ height, weight, waist circumference, smoking status, and comorbidities were recorded. Blood pressure, fasting blood glucose, triglyceride, HDL, total cholesterol, and insulin levels were measured. Seborrheic dermatitis area and severity index (SASI) score, body mass index (BMI), and Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) were calculated. The presence of metabolic syndrome was evaluated.
Results: BMI, waist circumference, glucose, HOMA-IR, and C-reactive protein (C-RP) were significantly higher in the SD group. The prevalence of hypertension and type II diabetes was significantly higher in the SD group than in the controls. There was no difference between the patient and control groups regarding metabolic syndrome. However, the duration of SD was significantly higher in SD with metabolic syndrome than those of SD without metabolic syndrome. There were no significant differences in age and SASI score between seborrheic dermatitis patients with and without metabolic syndrome.
Conclusion: SD patients may have an increased risk of metabolic syndrome development and may have higher inflammation and insulin resistance status compared with controls.

Keywords

Metabolic syndrome, Seborrheic Dermatitis, Insulin resistance, Hypertension

Ethical Statement

The research protocol was approved by the Sakarya University Clinical Research Ethics Committee (approval number: E-16214662-050.01.04-175)

Supporting Institution

none

Seboreik Dermatitli Hastalarda İnsülin Direnci ve Metabolik Sendrom Parametrelerinin Değerlendirilmesi

Abstract

Amaç: Seboreik dermatit (SD) yaygın görülen inflamatuar bir deri hastalığıdır. SD ve metabolik sendrom ile ilgili az veri vardır. Bu çalışmada seboreik dermatitli hastalarda metabolik sendrom prevalansını araştırmayı amaçladık.
Yöntem: Çalışmaya seboreik dermatit tanılı 66 hasta ve 52 sağlıklı kontrol dahil edildi. Olguların boyları, kiloları, bel çevreleri, sigara içme durumları ve ek hastalıkları kaydedildi. Kan basıncı, açlık kan şekeri, trigliserit, HDL ve total kolesterol, insülin düzeyleri ölçüldü. Seboreik dermatit alan ve şiddet indeksi (SASI) skoru, vücut kitle indeksi (VKİ) ve Homeostatik Model Değerlendirme-İnsülin Direnci (HOMA-IR) hesaplandı. Metabolik sendrom varlığı değerlendirildi.
Bulgular: VKİ, bel çevresi, glukoz, HOMA-IR ve C-Reaktif Protein (C-RP) SD grubunda anlamlı olarak yüksekti. Hipertansiyon ve tip II diyabet prevalansı SD grubunda kontrol grubuna göre anlamlı derecede yüksekti. Metabolik sendrom varlığı açısından gruplar arasında fark izlenmedi Ancak metabolik sendromlu SD'de SD süresi, metabolik sendromu olmayan SD'ye göre anlamlı olarak daha yüksekti. Metabolik sendromu olan ve olmayan seboreik dermatitli hastalar arasında yaş ve SASI skoru açısından anlamlı fark yoktu.
Sonuç: SD hastalarında metabolik sendrom gelişme riski artmış olabilir. Seboreik dermatit (SD) hastalarında kontrollere kıyasla daha yüksek inflamasyon ve insülin direnci durumu olabileceğini belirledik.

Keywords

Metabolik sendrom, Seboreik dermatit, İnsülin direnci, Hipertansiyon

References

• Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin Dermatol. 2013;31(4):343-351. doi:10.1016/j.clindermatol.2013.01.001
• Gupta AK, Bluhm R. Seborrheic dermatitis. J Eur Acad Dermatol Venereol. 2004;18(1):13-20. doi:10.1111/j.1468-3083.2004.00693.x
• Naldi L. Seborrhoeic dermatitis. BMJ Clin Evid. 2010;2010:1713.
• Schwartz RA, Janusz CA, Janniger CK. Seborrheic dermatitis: an overview. Am Fam Physician. 2006;74(1):125-130.
• Kibar M, Aktan Ş, Bilgin M. Dermoscopic findings in scalp psoriasis and seborrheic dermatitis; two new signs; signet ring vessel and hidden hair. Indian J Dermatol. 2015;60(1):41-45. doi:10.4103/0019-5154.147786
• Robati RM, Partovi-Kia M, Haghighatkhah HR, Younespour S, Abdollahimajd F. Increased serum leptin and resistin levels and increased carotid intima-media wall thickness in patients with psoriasis: is psoriasis associated with atherosclerosis? J Am Acad Dermatol. 2014;71(4):642-648. doi:10.1016/j.jaad.2014.06.006
• Evensen K, Slevolden E, Skagen K, et al. Increased subclinical atherosclerosis in patients with chronic plaque psoriasis. Atherosclerosis. 2014;237(2):499-503. doi:10.1016/j.atherosclerosis.2014.10.008
• Miller IM, Ellervik C, Yazdanyar S, Jemec GB. Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors. J Am Acad Dermatol. 2013;69(6):1014-1024. doi:10.1016/j.jaad.2013.06.053
• Linder D, Dreiher J, Zampetti A, Sampogna F, Cohen AD. Seborrheic dermatitis and hypertension in adults: a cross-sectional study. J Eur Acad Dermatol Venereol. 2014;28(11):1450-1455. doi:10.1111/jdv.12310
• Dowlati B, Firooz A, Khamesipour A, et al. Insulin quantification in patients with seborrheic dermatitis. Arch Dermatol. 1998;134(8):1043-1045. doi:10.1001/archderm.134.8.1043
• Smith SA, Baker AE, Williams JH. Effective treatment of seborrheic dermatitis using a low dose, oral homeopathic medication consisting of potassium bromide, sodium bromide, nickel sulfate, and sodium chloride in a double-blind, placebo-controlled study. Altern Med Rev. 2002;7(1):59-67.
• Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419.
• Grundy SM, Cleeman JI, Daniels SR, Donato KA, Echel RH, Franklin BA. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735-2752. doi:10.1161/CIRCULATIONAHA. 105.169404
• Watanabe S, Kano R, Sato H, Nakamura Y, Hasegawa A. The effects of Malassezia yeasts on cytokine production by human keratinocytes. J Invest Dermatol. 2001;116(5):769-773. doi:10.1046/j.1523-1747.2001.01321.x
• Tosun M, Yasak Güner R, Akyol M. Investigation of the relationship between inflammatory blood parameters and seborrheic dermatitis. J Cosmet Dermatol. 2022;21(10):5111-5115. doi:10.1111/jocd.14984
• Savaş Erdoğan S, Falay Gür T, Özkur E, Dogan B. Insulin Resistance and Metabolic Syndrome in Patients with Seborrheic Dermatitis: A Case-Control Study. Metab Syndr Relat Disord. 2022;20(1):50-56. doi:10.1089/met.2021.0063
• Radi S, Binmahfooz S, Nawar S, Hebah M. Alström Syndrome: A Rare Cause of Severe Insulin Resistance. JCEM Case Rep. 2022;1(1):luac012. doi:10.1210/jcemcr/luac012