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Evaluation of the Parotid Gland with Ultrasonography of Patients with Type 2 Diabetes

Year 2025, Volume: 4 Issue: 2, 83 - 88, 28.08.2025

Abstract

Amaç
Bu çalışmanın amacı tip 2 diyabeti olan hastaların parotis bezi kalınlıklarını ultrasonografi ile değerlendirmektir.
Gereç ve Yöntemler
Toplam 50 hasta iki haftalık aralıklarla bir gözlemci tarafından iki kez muayene edilmiştir. Her iki parotis bezi nin ultrasonografik incelemesi sırasında prob, hastanın dişleri okluzyondayken transvers (kraniokaudal) ve longitudinal (anteroposterior) yönlerde hareket ettirilmiştir. Ölçümler sırasında hasta, başı bir yastığa dayalı olarak düz bir zeminde yatmıştır. Bulgular Kontrol grubunda, sağ parotis bezleri sol parotis bezlerinden anlamlı derecede daha kalındı (p = 0.023). Ancak, tip 2 diyabetli hastalarda sağ ve sol taraflar arasında parotis bezi kalınlığı açısından anlamlı bir fark yoktu (p = 0.275). Tip 2 diyabetli hastalar ile kontrol grubu arasında da parotis bezi kalınlığı açısından anlamlı bir fark yoktu (P > 0.05).
Sonuç
Ultrasonografi, sistemik hastalıkların baş ve boyun yu muşak dokuları üzerindeki etkisini tespit etmek ve izlemek için ileriye dönük bir tanı testi olabilir, ancak daha fazla araştırmaya ihtiyaç vardır.

References

  • 1. Hand AR. Salivary glands. Dental Science for the Medical Professional: An Evidence-Based Approach; 2023. p.49-66.
  • 2. Lawrence JM, Divers J, Isom S et al. Trends in prevalence of type 1 and type 2 diabetes in children and adolescents in the US, 2001-2017. Jama. 2021; 326(8): 717-727.
  • 3. Carda C, Mosquera-Lloreda N, Salom L et al. Structural and functional salivary disorders in type 2 diabetic patients. Medicina Oral Patologia Oral y Cirugia Bucal. 2006; 11(4): 209. 4. Hausegger KW, Krasa H, Plezmann W et. al. Sonogrphie der spichelderusen. Ultraschall Med. 1993; 14:68-74.
  • 5. Tomic D, Jonathan E, Dianna JM The burden and risks of emerging complications of diabetes mellitus. Nature Reviews Endocrinology. 2022; 18.9: 525-539.
  • 6. Spinnato P, Patel DB, Di Carlo M et al. Imaging of musculoskeletal soft-tissue infections in clinical practice: a comprehensive updated review. Microorganisms. 2022; 10(12): 2329.
  • 7. Hussain S, Mubeen I, Ullah N et al. Modern diagnostic imaging technique applications and risk factors in the medical field: a review. BioMed research international. 2022(1); 5164970.
  • 8. Rumack CM Diagnostic ultrasound. Elsevier/Mosby. 2011; 1(vol 1): 2-33.
  • 9. Afzelius P, Nielsen MY, Ewertsen C et al. Imaging of the major salivary glands. Clin Physiol Funct Imaging. 2016; 36(1): 1–10.
  • 10. Carotti M, Ciapetti A, Jousse-Joulin S et al. Ultrasonography of the salivary glands: the role of greyscale and colour/power Doppler. Clin Exp Rheumatol. 2014; 32(1 Suppl 80): 61–70.
  • 11. Fouani M, Basset CA, Jurjus AR et al. Salivary gland proteins alterations in the diabetic milieu. Journal of molecular histology, 2021; 52: 893-904.
  • 12. Mandel L, Khelemsky R Asymptomatic bilateral facial swelling. J Am Dent Assoc. 2012; 143(11): 1205-1208.
  • 13. Mandel L, Patel S. Sialadenosis associated with diabetes mellitus: a case report. J Oral Maxillofac Surg. 2002; 60(6): 696-698.
  • 14. Monteiro MM, D'Epiro TTS, Bernardi L et al. Long-and short-term diabetes mellitus type 1 modify young and elder rat salivary glands morphology. Arch Oral Biol. 2017; 73: 40-47.
  • 15. Gupta A, Ramachandra VK, Khan M et al. A cross-sectional study on ultrasonographic measurements of parotid glands in type 2 diabetes mellitus. Int J Dent. 2021; 2021:5583412.
  • 16. Lilliu MA, Solinas P, Cossu M et al. Diabetes causes morphological changes in human submandibular gland: a morphometric study. J Oral Pathol Med. 2015; 44(4): 291-295.
  • 17. Ozturk EMA, Yalcin ED. Evaluation of submandibular and parotid salivary glands by ultrasonography in patients with diabetes. Journal of Oral Rehabilitation. 2024; 51(7): 1144-1157.
  • 18. Yüksel KE, Geduk, G. Evaluation of parotid and submandibular salivary glands with ultrasonography in diabetic patients. Clinical Oral Investigations. 2025; 29(2), 95.
  • 19. Bowers LM, Vissink A, Brennan MT. Salivary gland diseases. Burket's Oral Medicine. 2021.p.281-347.
  • 20. Mandel, L. Sialadenosis. In: Clinical Management of Salivary Gland Disorders. Cham: Springer International Publishing. 2024.p.157-172.
  • 21. Neville BW, Damm DD, Allen CM et al. Oral and maxillofacial pathology. Philadelpia: Saunders Company Ed. 2002; 404-5.
  • 22. Scott J, Burns J, Flower EA. Histological analysis of parotid and submandibular glands in chronic alcohol abuse: a necropsy study. Journal of clinical pathology. 1988; 41(8): 837-840.
  • 23. Sleman WL, Zainab H, Ahlam A. Factors associated with parotid gland enlargement among poorly controlled Type II Diabetes Mellitus. Scientific Journal Published by the College of Dentistry–University of Baghdad. 2011; 23(3): 80-82.

Evaluation of the Parotid Gland with Ultrasonography of Patients with Type 2 Diabetes

Year 2025, Volume: 4 Issue: 2, 83 - 88, 28.08.2025

Abstract

Objective
The aim of this study was to evaluate the parotid gland thickness of patients with type 2 diabetes by ultrasonography.
Material and Methods
A total of 50 patients were examined twice by 1 observer at 2 week intervals. During ultrasonographic examination of both parotid glands, the probe was moved in trans verse (craniocaudal) and longitudinal (anteroposterior) directions while the patient's teeth were occluded. During the measurements, the patient lay on a flat surface with their head resting on a pillow.
Results
In the control group, the right parotid glands were significantly thicker than the left parotid glands (p = 0.023). However, there was no significant difference in parotid gland thickness between the right and left sides in patients with type 2 diabetes (p = 0.275). There was also no significant difference in parotid gland thicknesses between patients with type 2 diabetes and the control group (P > 0.05).
Conclusion
Ultrasonography may be a prospective diagnostic test for detecting and monitoring the impact of systemic diseases on the soft tissues of the head and neck, but more research is needed.

References

  • 1. Hand AR. Salivary glands. Dental Science for the Medical Professional: An Evidence-Based Approach; 2023. p.49-66.
  • 2. Lawrence JM, Divers J, Isom S et al. Trends in prevalence of type 1 and type 2 diabetes in children and adolescents in the US, 2001-2017. Jama. 2021; 326(8): 717-727.
  • 3. Carda C, Mosquera-Lloreda N, Salom L et al. Structural and functional salivary disorders in type 2 diabetic patients. Medicina Oral Patologia Oral y Cirugia Bucal. 2006; 11(4): 209. 4. Hausegger KW, Krasa H, Plezmann W et. al. Sonogrphie der spichelderusen. Ultraschall Med. 1993; 14:68-74.
  • 5. Tomic D, Jonathan E, Dianna JM The burden and risks of emerging complications of diabetes mellitus. Nature Reviews Endocrinology. 2022; 18.9: 525-539.
  • 6. Spinnato P, Patel DB, Di Carlo M et al. Imaging of musculoskeletal soft-tissue infections in clinical practice: a comprehensive updated review. Microorganisms. 2022; 10(12): 2329.
  • 7. Hussain S, Mubeen I, Ullah N et al. Modern diagnostic imaging technique applications and risk factors in the medical field: a review. BioMed research international. 2022(1); 5164970.
  • 8. Rumack CM Diagnostic ultrasound. Elsevier/Mosby. 2011; 1(vol 1): 2-33.
  • 9. Afzelius P, Nielsen MY, Ewertsen C et al. Imaging of the major salivary glands. Clin Physiol Funct Imaging. 2016; 36(1): 1–10.
  • 10. Carotti M, Ciapetti A, Jousse-Joulin S et al. Ultrasonography of the salivary glands: the role of greyscale and colour/power Doppler. Clin Exp Rheumatol. 2014; 32(1 Suppl 80): 61–70.
  • 11. Fouani M, Basset CA, Jurjus AR et al. Salivary gland proteins alterations in the diabetic milieu. Journal of molecular histology, 2021; 52: 893-904.
  • 12. Mandel L, Khelemsky R Asymptomatic bilateral facial swelling. J Am Dent Assoc. 2012; 143(11): 1205-1208.
  • 13. Mandel L, Patel S. Sialadenosis associated with diabetes mellitus: a case report. J Oral Maxillofac Surg. 2002; 60(6): 696-698.
  • 14. Monteiro MM, D'Epiro TTS, Bernardi L et al. Long-and short-term diabetes mellitus type 1 modify young and elder rat salivary glands morphology. Arch Oral Biol. 2017; 73: 40-47.
  • 15. Gupta A, Ramachandra VK, Khan M et al. A cross-sectional study on ultrasonographic measurements of parotid glands in type 2 diabetes mellitus. Int J Dent. 2021; 2021:5583412.
  • 16. Lilliu MA, Solinas P, Cossu M et al. Diabetes causes morphological changes in human submandibular gland: a morphometric study. J Oral Pathol Med. 2015; 44(4): 291-295.
  • 17. Ozturk EMA, Yalcin ED. Evaluation of submandibular and parotid salivary glands by ultrasonography in patients with diabetes. Journal of Oral Rehabilitation. 2024; 51(7): 1144-1157.
  • 18. Yüksel KE, Geduk, G. Evaluation of parotid and submandibular salivary glands with ultrasonography in diabetic patients. Clinical Oral Investigations. 2025; 29(2), 95.
  • 19. Bowers LM, Vissink A, Brennan MT. Salivary gland diseases. Burket's Oral Medicine. 2021.p.281-347.
  • 20. Mandel, L. Sialadenosis. In: Clinical Management of Salivary Gland Disorders. Cham: Springer International Publishing. 2024.p.157-172.
  • 21. Neville BW, Damm DD, Allen CM et al. Oral and maxillofacial pathology. Philadelpia: Saunders Company Ed. 2002; 404-5.
  • 22. Scott J, Burns J, Flower EA. Histological analysis of parotid and submandibular glands in chronic alcohol abuse: a necropsy study. Journal of clinical pathology. 1988; 41(8): 837-840.
  • 23. Sleman WL, Zainab H, Ahlam A. Factors associated with parotid gland enlargement among poorly controlled Type II Diabetes Mellitus. Scientific Journal Published by the College of Dentistry–University of Baghdad. 2011; 23(3): 80-82.
There are 22 citations in total.

Details

Primary Language English
Subjects Oral and Maxillofacial Radiology
Journal Section Research Articles
Authors

Tansu Çimen 0000-0002-9999-0811

Füsun Yaşar 0000-0003-0720-0892

Publication Date August 28, 2025
Submission Date May 22, 2025
Acceptance Date July 7, 2025
Published in Issue Year 2025 Volume: 4 Issue: 2

Cite

Vancouver Çimen T, Yaşar F. Evaluation of the Parotid Gland with Ultrasonography of Patients with Type 2 Diabetes. Akd Dent J. 2025;4(2):83-8.

Founded: 2022

Period: 3 Issues Per Year

Publisher: Akdeniz University