Case Report
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Bupropion Kullanımına Bağlı Asemptomatik Transaminaz Yükselmesi: Olgu Sunumu ve Literatür Taraması

Year 2016, , 367 - 373, 15.12.2016
https://doi.org/10.30569/adiyamansaglik.375764

Abstract










Bupropion major depresyon tedavisinde genel olarak güvenli ve iyi tolere
edilebilir bir seçenektir. Preklinik çalışmalarda serum transaminaz
seviyelerinde hafif ve geçici yükselmelere neden olduğu gösterilmiştir. Bu vaka
sunumunda başka bir rahatsızlığı olmayan major depresyon hastasında bupropion
kullanımından sonra gelişen ve ilaç kesilince düzelen transaminaz yükselmesi
rapor edilmektedir.

References

  • 1. Wilkes S. Bupropion. Drugs Today (Barc) 2006;42:671-81
  • 2. Alvaro D, Onetti-Muda A, Moscatelli R, Attili AF. Acute cholestatic hepatitis induced by bupropion prescribed as pharmacological support to stop smoking. A case report. Dig Liver Dis 2001;33:703-6.
  • 3. Tucker WE, Preclinical toxicology of bupropion, an owerview. J clin. Psychiatry 1983;44:60-2.
  • 4. Oslin DW, Duffy K. The rise of serum aminotransferases in a patient treated with bupropion. J Clin Psychopharmacol 1993;13:364-5.
  • 5. Khoo AL, Tham LS, Lee KH, Lim GK. Acute liver failure with concurrent bupropion and carbimazole therapy. Ann Pharmacother 2003;37: 220-3. DOI 10.1345/aph.1C159.
  • 6. Bagshaw SM, Cload B, Gilmour J, Leung ST, Bowen TJ. Drug-induced rash with eosinophilia and systemic symptoms syndrome with bupropion administration. Ann Allergy Asthma Immunol 2003;90:572-5.
  • 7. Hu KQ, Tiyyagura L, Kanel G, Redeker AG. Acute hepatitis induced by bupropion. Dig Dis Sci 2000;45:1872-3.
  • 8. Humayun F, Shehab TM, Tworek JA, Fontana RJ: A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: case report. J Med Case Reports 2007;1:88.
  • 9. Verma S, Kaplowitz N: Diagnosis, management, and prevention of drug-induced liver injury. Gut 2009; 58:1555–64.

Asymptomatic Transaminase Elevation Due to Bupropion: Case Report and Overview of the Literature

Year 2016, , 367 - 373, 15.12.2016
https://doi.org/10.30569/adiyamansaglik.375764

Abstract

Generally bupropion is considered as a safe and well-tolerated
antidepressant for the treatment of major depression. In preclinical studies,
mild and transient elevation of serum aminotransferases  was observed and also phase 3 studies
revealed this increase as up to 1%. In this case report, we aimed to present a
major depression patient with asymptomatic elevation of liver enzymes after
bupropion treatment which returned to normal values after bupropion stopped.

References

  • 1. Wilkes S. Bupropion. Drugs Today (Barc) 2006;42:671-81
  • 2. Alvaro D, Onetti-Muda A, Moscatelli R, Attili AF. Acute cholestatic hepatitis induced by bupropion prescribed as pharmacological support to stop smoking. A case report. Dig Liver Dis 2001;33:703-6.
  • 3. Tucker WE, Preclinical toxicology of bupropion, an owerview. J clin. Psychiatry 1983;44:60-2.
  • 4. Oslin DW, Duffy K. The rise of serum aminotransferases in a patient treated with bupropion. J Clin Psychopharmacol 1993;13:364-5.
  • 5. Khoo AL, Tham LS, Lee KH, Lim GK. Acute liver failure with concurrent bupropion and carbimazole therapy. Ann Pharmacother 2003;37: 220-3. DOI 10.1345/aph.1C159.
  • 6. Bagshaw SM, Cload B, Gilmour J, Leung ST, Bowen TJ. Drug-induced rash with eosinophilia and systemic symptoms syndrome with bupropion administration. Ann Allergy Asthma Immunol 2003;90:572-5.
  • 7. Hu KQ, Tiyyagura L, Kanel G, Redeker AG. Acute hepatitis induced by bupropion. Dig Dis Sci 2000;45:1872-3.
  • 8. Humayun F, Shehab TM, Tworek JA, Fontana RJ: A fatal case of bupropion (Zyban) hepatotoxicity with autoimmune features: case report. J Med Case Reports 2007;1:88.
  • 9. Verma S, Kaplowitz N: Diagnosis, management, and prevention of drug-induced liver injury. Gut 2009; 58:1555–64.
There are 9 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Report
Authors

Osman Hasan Tahsin Kılıç This is me 0000-0001-8426-2072

İhsan Aksoy

Bahadır Demir This is me

Publication Date December 15, 2016
Submission Date January 6, 2018
Acceptance Date February 24, 2018
Published in Issue Year 2016

Cite

AMA Kılıç OHT, Aksoy İ, Demir B. Asymptomatic Transaminase Elevation Due to Bupropion: Case Report and Overview of the Literature. ADYÜ Sağlık Bilimleri Derg. December 2016;2(3):367-373. doi:10.30569/adiyamansaglik.375764