The effects of transfer day in intracytoplasmic sperm injection (ICSI) pregnancies on first trimester screening test results

Year 2018, , 1083 - 1093, 15.12.2018

Nur Dokuzeylül Güngör , Tuğba Gürbüz , Aynur Erşahin

https://doi.org/10.30569/adiyamansaglik.440359

Cited By: 1

Abstract

Objects: To compare first trimesterscrening (FTS) serum markers free
β-human chorionic gonodotropin (free β-hCG and pregnancy associated plasma
protein A (PAPP-A)  of blastocyst versus
cleavage stage embryo transfers after assisted
reproductive technologies (ART).

Methods: Retrospective
examinations of 123 women who conceived with ART were subjected to FTS from
January 2017 to December 2017 at Bahçeşehir University Göztepe Medical Park
Hospital In Vitro Fertilization (IVF) Unit.The age,gestational week,ultrasound
(US) markers and biochemistry markers(PAPP-A,free β-hCG) were
collected.Outcomes were regarded as meaningful when the p < 0.05.
Statistical Package For Social Sciences (SPSS) v.17.0 for Windows was preferred
to make statistical analysis.

Results: PAPP-A
amounts were remarkably low in day-3 (cleavage stage embryos) transfer
intracytoplasmic sperm injection (ICSI) pregnancies compared to day-5
(blastocyst stage embryos) transfer ICSI pregnancies.Free β-hCG amounts weren’t
significantly different in two groups (p=0.371). NT was unaffected by the
transferenceday (p=0.21). Also CRL wasunaffected by the transferenceday
(p=0.693). No differences appeared between 3rd and 5th day embryo transference
according to maternal age (p=0.616), weight (p=0.693) and gestational age
(p=0.742) at sampling.

Conclusion: Today,
the datas about the effects of ART over the ingredients of combined FTS for
chromosomal analysis are contentious yet.Day-3 ICSI pregnancies had
meaningfully low PAPP-A amounts which support the requirement to properly set
the combined FTS risks algoritm. These outcomes are likely to be because of
changings in the placenta of ART pregnancies.

Keywords

Assisted reproduction techniques, blastocyst, cleavage, first trimester screening

The effects of transfer day in intracytoplasmic sperm injection (ICSI) pregnancies on first trimester screening test results

Abstract

Objects

To
compare first trimester screning serum markers free β-human chorionic
gonodotropin (free β-hCG and pregnancy associated plasma protein A (PAPP-A)  of blastocyst versus cleavage stage embryo
transfers after assisted reproductive technologies (ART) .

Methods

Retrospective
analysis of 123 women who conceived with ART
undergone first-trimester  screening between
January 2017 and December 2017 at Bahçeşehir University Göztepe Medical Park Hospital  IVF Unit. The age, gestational week, ultrasound
markers and biochemistry  markers (PAPP- A,free
β-hCG) were collected. Results were considered significant when the p value was
less than 0.05. Statistical Package For Social Sciences (SPSS) version 17.0 for
Windows was used for statistical analysis.

Results

PAPP-A
levels were significantly lower in day-3 (cleavage stage embryos) transfer intracytoplasmic sperm injection (ICSI) pregnancies
compared to day-5 (blastocyst stage embryos) transfer ICSI pregnancies (p<0.05).
Free β-hCG levels weren’t significantly differ in two groups (p=0.371). NT was
unaffected by the day of transfer (p=0.21). Also CRL wasn’t affected by the day
of transfer (p=0.693). No differences appeared between day-3 and day-5 embryo
transfer with respect to maternal age ,(p=0.616) weight (p=0.693) and gestational
age (p=0.742)  at sampling.

 

Conclusion

Today,
the data on the effect of ART on the components of first trimester combined
screening

for
chromosomal analysis are still controversial. Day-3  ICSI  pregnancies 
had significantly

lower
PAPP-A levels supporting the need to appropriately adjust the combined first trimester

screening
(cFTS) risk algoritm. These results may be due to alterations in the
placentation of ART pregnancies.

Keywords

Assisted reproduction techniques, blastocyst, cleavage, first trimester screening

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