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Diz osteoartritli hastalarda ortalama platelet hacmi ve platelet dağılım genişliği parametrelerinin değerlendirilmesi

Year 2018, Volume: 4 Issue: 2, 750 - 760, 15.08.2018
https://doi.org/10.30569/adiyamansaglik.377453

Abstract

Amaç:
Bu
çalışmanın amacı, diz osteoartriti tanılı hastalarda ortalama platelet hacmi (OPH)
ve platelet dağılım genişliği (PDG) parametrelerinin değerlendirilmesiydi.

Yöntem:
Çalışmamıza
Ocak 2016 - Aralık 2017 tarihleri arasında Adıyaman Üniversitesi Fiziksel Tıp
Ve Rehabilitasyon polikliniğine başvuran diz osteoartriti tanısı olan 453 hasta
(Gonartroz Grubu) ve bu grupla yaş ve cinsiyet olarak benzer özelliklere sahip
ancak diz osteoartriti tanısı olmayan 341 hasta (Kontrol Grubu) dahil edildi. Hastaların
yaşı, cinsiyeti, platelet sayıları (PS), OPH ve PDG değerleri retrospektif
olarak hastane kayıtları üzerinden elde edilerek kaydedildi. Her iki grup PS, OPH
ve PDG değerleri açısından karşılaştırıldı.

Bulgular:
Gonartroz
grubunda, ortalama OPH düzeyi kontrol grubuna göre anlamlı olarak daha düşük
iken (p=0,001), ortalama PDG değerleri anlamlı olarak daha yüksekti (p=0,003). Ortalama
PS düzeyi Gonartroz grubunda hafif düzeyde daha düşük olmasına rağmen fark
istatistiksel olarak anlamlı değildi (p=0,298).







Sonuç:
Bu
çalışma diz osteoartritli hastalarda OPH ve PDG parametrelerinin diz
osteoartriti tanısı olmayan kişilerden anlamlı olarak farklılık
gösterebileceğini ortaya koymaktadır. Literatürde farklılık olmadığını bildiren
çalışmaların da olması, konuyu tartışmalı kılmaktadır. Daha geniş serilerde,
klinik parametreleri de içeren prospektif çalışmaların fayda sağlayacağı
kanaatindeyiz.

References

  • 1. Evcik D, Ay S. Osteoartrit patogenezi. Editör: Ataman Ş, Yalçın P. Romatoloji. Yayınevi: Akademisyen Kitabevi İstanbul, Turkey, 2012: 659-666
  • 2. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. Theprevalence of kneeosteoarthritis in theelderly. The Framingham Osteoarthritis Study. Arthritis & Rheumatology 1987; 30(8): 914-8
  • 3. Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. The Journal of Rheumatology 1997; 24: 365-71
  • 4. Tetik Ş, Ak K, Yardımcı KT. Trombosit fonksiyon testlerini etkileyen faktörler. Cumhuriyet Medical Journal 2012; 34(1): 123-127
  • 5. Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians ? American Journal of Clinical Pathology 2002; 118(5): 787–793
  • 6. Jagroop A, Clatworthy I, Lewin J, Mikhailidis DP. Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy. Platelets 2000; 11: 28-32
  • 7. Osselaer JC, Jamart J, Scheiff JM. Platelet distribution width for differential diagnosis of thrombocytosis. Clinical Chemistry 1997; 43: 1072-1076
  • 8. McNicol A, Israels SJ. Beyond hemostasis: the role of platelets in inflammation, malignancy and infection. Cardiovascular & Haematological Disorders-Drug Targets (Formerly Current Drug Targets-Cardiovascular & Hematological Disorders) 2008; 8: 99-117
  • 9. Yildirim A, Karabiber M, Surucu GD, Türkbeyler IH, Karakoyun A, Selkuc MY, et al. The changes of mean platelet volume and platelet distribution width ın patients with rheumatoid arthritis and their correlation with disease activity. Acta Medica Mediterranea 2015; 31: 1105-1111
  • 10. Milovanovic M, Nilsson E, Järemo P. Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clinica Chimica Acta 2004; 343: 237-240
  • 11. Gasparyan AY, Ayvazyan L, Mikhailidis DM, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Current Pharmaceutical Design 2011; 17(1): 47–58
  • 12. Pauling D, O’Donnell VB, Mchugh NJ. The contribution of platelets to the pathogenesis of Raynaud’s phenomenon and systemic sclerosis. Platelets 2013; 24(7): 503-515
  • 13. Dan K, Gomi S, Inokuchi K, Ogata K, Yamada T, Ohki I, et al. Effects of lnterleukin-1 and Tumor Necrosis Factor on Megakaryocytopoiesis: Mechanism of Reactive Thrombocytosis. Acta Haematologica 1995; 93: 67-72
  • 14. Ünsal E, Aksaray S, Köksal D, Şipit T. Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Postgraduate Medical Journal 2005; 81: 604-607
  • 15. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nature Reviews Rheumatology 2010; 6: 625–635
  • 16. Goldring MB, Otero M. Inflammation in osteoarthritis. Current Opinion in Rheumatology 2011; 23: 471-478
  • 17. Benito MJ, Veale, DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Annals of the Rheumatic Diseases 2005; 64: 1263-1267
  • 18. Furuzawa-Carballeda J, Macip-Rodriguez PM, Cabral AR. Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. Clinical and Experimental Rheumatology 2008; 26: 554-560
  • 19. Farahat MN, Yanni G, Poston R, Panayi GS. Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Annals of the Rheumatic Diseases 1993; 52: 870-875
  • 20. Furuzawa-Carballeda J, Alcocer-varela J. Interleukin-8, interleukin-10, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression levels are higher in synovial tissue from patients with rheumatoid arthritis than in osteoarthritis. Scandinavian Journal of Immunology 1999; 50: 215–222
  • 21. Yıldırım A, Bulut HT. Postmenopozal kadınlarda kemik mineral yoğunluğu ile platelet endeksleri arasındaki ilişki. Turkish Journal of Osteoporosis /Turk Osteoporoz Dergisi 2016: 22(2): 92-96
  • 22- Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets 2014; 25: 81-5
  • 23 - Hira S , Tamam C. Diagnostic value of hematological parameters in patients with osteoarthritis. Cukurova Medical Journal 2017; 42(1): 120-125
  • 24. Santimone I, Di Castelnuovo A, De Curtis A, Spinelli M, Cugino D, Gianfagna F, ... & Iacoviello, L. White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project. Haematologica 2011; 96(8): 1180-1188
  • 25. Atar E, Aşkın A. Diz osteoartrit hastalarında nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi. Cukurova Medical Journal 2017; 42(2): 329-336

Evaluation of mean platelet volume and platelet distribution width parameters in patients with knee osteoarthritis.

Year 2018, Volume: 4 Issue: 2, 750 - 760, 15.08.2018
https://doi.org/10.30569/adiyamansaglik.377453

Abstract

Aim:  The aim of this study was to evaluate the mean
platelet volume (MPV) and platelet distribution width (PDW) parameters in
patients with knee osteoarthritis.

Material and
Methods:
Four hundred fifty-three patients diagnosed with knee
osteoarthritis (Gonarthrosis Group) who admitted to the Physical Medicine and
Rehabilitation outpatient clinic of Adıyaman Education and Research Hospital
between January 2016 and December 2017 and 341 subjects with similar
characteristics as age and gender but without knee osteoarthritis and not
having any disease affecting thrombocyte count and function (Control Group)
were included this study. Patients' age, gender, platelet count (PC), MPV and
PDW values were recorded retrospectively from hospital records.
Both groups
were compared in terms of PC, MPV and PDW values.

Results: In the
gonarthrosis group, mean MPV levels (7,84 ± 1,58 fL) were significantly lower
than the control group (8,23 ± 1,69 fL; p = 0.001) and mean PDW values were
significantly higher (18,67 ± 1,81 fL and 18,12 ± 3,31 fL, respectively; p =
0.003). Although the mean PC level was slightly lower in the gonarthrosis
group, the difference was not statistically significant (p = 0.298).







Conclusion: This study
suggests that MPV and PDW parameters in patients with knee osteoarthritis may
differ significantly from those without knee osteoarthritis.  The fact that there are studies in the
literature that there is no difference makes this issue controversial. We
believe that prospective studies in larger series and including clinical
parameters would be useful.

References

  • 1. Evcik D, Ay S. Osteoartrit patogenezi. Editör: Ataman Ş, Yalçın P. Romatoloji. Yayınevi: Akademisyen Kitabevi İstanbul, Turkey, 2012: 659-666
  • 2. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. Theprevalence of kneeosteoarthritis in theelderly. The Framingham Osteoarthritis Study. Arthritis & Rheumatology 1987; 30(8): 914-8
  • 3. Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. The Journal of Rheumatology 1997; 24: 365-71
  • 4. Tetik Ş, Ak K, Yardımcı KT. Trombosit fonksiyon testlerini etkileyen faktörler. Cumhuriyet Medical Journal 2012; 34(1): 123-127
  • 5. Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians ? American Journal of Clinical Pathology 2002; 118(5): 787–793
  • 6. Jagroop A, Clatworthy I, Lewin J, Mikhailidis DP. Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy. Platelets 2000; 11: 28-32
  • 7. Osselaer JC, Jamart J, Scheiff JM. Platelet distribution width for differential diagnosis of thrombocytosis. Clinical Chemistry 1997; 43: 1072-1076
  • 8. McNicol A, Israels SJ. Beyond hemostasis: the role of platelets in inflammation, malignancy and infection. Cardiovascular & Haematological Disorders-Drug Targets (Formerly Current Drug Targets-Cardiovascular & Hematological Disorders) 2008; 8: 99-117
  • 9. Yildirim A, Karabiber M, Surucu GD, Türkbeyler IH, Karakoyun A, Selkuc MY, et al. The changes of mean platelet volume and platelet distribution width ın patients with rheumatoid arthritis and their correlation with disease activity. Acta Medica Mediterranea 2015; 31: 1105-1111
  • 10. Milovanovic M, Nilsson E, Järemo P. Relationships between platelets and inflammatory markers in rheumatoid arthritis. Clinica Chimica Acta 2004; 343: 237-240
  • 11. Gasparyan AY, Ayvazyan L, Mikhailidis DM, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Current Pharmaceutical Design 2011; 17(1): 47–58
  • 12. Pauling D, O’Donnell VB, Mchugh NJ. The contribution of platelets to the pathogenesis of Raynaud’s phenomenon and systemic sclerosis. Platelets 2013; 24(7): 503-515
  • 13. Dan K, Gomi S, Inokuchi K, Ogata K, Yamada T, Ohki I, et al. Effects of lnterleukin-1 and Tumor Necrosis Factor on Megakaryocytopoiesis: Mechanism of Reactive Thrombocytosis. Acta Haematologica 1995; 93: 67-72
  • 14. Ünsal E, Aksaray S, Köksal D, Şipit T. Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Postgraduate Medical Journal 2005; 81: 604-607
  • 15. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nature Reviews Rheumatology 2010; 6: 625–635
  • 16. Goldring MB, Otero M. Inflammation in osteoarthritis. Current Opinion in Rheumatology 2011; 23: 471-478
  • 17. Benito MJ, Veale, DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Annals of the Rheumatic Diseases 2005; 64: 1263-1267
  • 18. Furuzawa-Carballeda J, Macip-Rodriguez PM, Cabral AR. Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. Clinical and Experimental Rheumatology 2008; 26: 554-560
  • 19. Farahat MN, Yanni G, Poston R, Panayi GS. Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Annals of the Rheumatic Diseases 1993; 52: 870-875
  • 20. Furuzawa-Carballeda J, Alcocer-varela J. Interleukin-8, interleukin-10, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression levels are higher in synovial tissue from patients with rheumatoid arthritis than in osteoarthritis. Scandinavian Journal of Immunology 1999; 50: 215–222
  • 21. Yıldırım A, Bulut HT. Postmenopozal kadınlarda kemik mineral yoğunluğu ile platelet endeksleri arasındaki ilişki. Turkish Journal of Osteoporosis /Turk Osteoporoz Dergisi 2016: 22(2): 92-96
  • 22- Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets 2014; 25: 81-5
  • 23 - Hira S , Tamam C. Diagnostic value of hematological parameters in patients with osteoarthritis. Cukurova Medical Journal 2017; 42(1): 120-125
  • 24. Santimone I, Di Castelnuovo A, De Curtis A, Spinelli M, Cugino D, Gianfagna F, ... & Iacoviello, L. White blood cell count, sex and age are major determinants of heterogeneity of platelet indices in an adult general population: results from the MOLI-SANI project. Haematologica 2011; 96(8): 1180-1188
  • 25. Atar E, Aşkın A. Diz osteoartrit hastalarında nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve ortalama trombosit hacminin değerlendirilmesi. Cukurova Medical Journal 2017; 42(2): 329-336
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Onur Kılınç

Ayşe Atılgan Çelik

Semra Coşkun

Adem Yıldırım

Publication Date August 15, 2018
Submission Date January 11, 2018
Acceptance Date February 5, 2018
Published in Issue Year 2018 Volume: 4 Issue: 2

Cite

AMA Kılınç O, Atılgan Çelik A, Coşkun S, Yıldırım A. Diz osteoartritli hastalarda ortalama platelet hacmi ve platelet dağılım genişliği parametrelerinin değerlendirilmesi. ADYÜ Sağlık Bilimleri Derg. August 2018;4(2):750-760. doi:10.30569/adiyamansaglik.377453