Helicobacter pylori infection in pediatric patients with celiac disease: A single-center experience

Year 2024, Volume: 10 Issue: 1, 55 - 59, 23.04.2024

Sibel Yavuz , Haci Ballı , Hatice Uygun , Merve Kılıç Çil

https://doi.org/10.30569/adiyamansaglik.1420528

Abstract

Aim: There are numerous studies investigating the relationship between celiac disease (CD) and Helicobacter pylori (H. pylori). In this study, we aimed to compare the prevalence of coexisting H. pylori infection and CD in pediatric patients diagnosed with celiac disease at our clinic versus an age-matched control group.
Materials and Methods: A total of 198 patients with celiac disease and 131 sex and age -matched controls undergoing upper gastrointestinal endoscopy due to dyspeptic complaints were included in this study. The prevalence of H. pylori was compared between the groups.
Results: Of the 198 patients with CD included in the study, 66 (33.3%) were male and 132 (66.7%) were female, while in the control group, 36 (27.5%) were male, and 95 (72.5%) were female. 89 (44%) of the patients with CD and 70 (53.4%) of the controls were H. pylori-positive. There was no statistically significant difference in the distribution of Marsh scores between the H. pylori-negative and -positive groups.
Conclusion: The association between celiac disease and H. pylori remains controversial. Thus, multicenter studies are warranted to evaluate the role of H. pylori in the pathogenesis of celiac disease.

Keywords

Celiac Disease, H. Pylori, Prevalence

Ethical Statement

This study was performed in line with the principles of the Declaration of Helsinki. Approval was obtained from the Institutional Review Board of Adıyaman University Faculty of Medicine.

Supporting Institution

No financial support was received for this study from a person or organization.

Çölyak hastalığı olan çocuk hastalarda Helicobacter pylori enfeksiyonu: Tek merkez deneyimi

Abstract

Amaç: Çölyak hastalığı ve Helicobacter pylori (H. pylori) arasındaki ilişkiyi araştıran birçok çalışma vardır. Biz çalışmamızda; kliniğimizde çölyak hastalığı tanısı almış hastalarda, Helicobacter pylori birlikteliğini ve yaş uyumlu kontrol grubu ile karşılaştırmayı amaçladık
Gereç ve Yöntem: Çalışmaya 198 çölyak hastası, yaş ve cinsiyet uyumlu, dispeptik şikayetleri nedeni ile üst gastrointestinal sistem endoskopisi yapılmış 131 kontrol hastası dahil edildi. İki grubun H. pylori prevalansları saptanarak aralarında farklılık olup olmadığı araştırıldı.
Bulgular: Çalışmaya alınan 198 çölyak hastasının 66 (%33,3)’sı erkek, 132 (%66,7)’si kız hasta ve kontrol grubunun 36 (%27.5)’ erkek, 95 (%72.5) kız hasta idi. Çölyak hastalığı olan 198 hastanın 89’unda (%44), kontrol grubundaki 131 hastanın 70’inde(%53.4) H. pylori pozitif saptandı. H. pylori pozitif ve negatif gruplar arasında Marsh skoru dağılımı açısından istatistiksel anlamlı fark saptanmadı.
Sonuç: Çölyak hastalığı ile H. pylori arasındaki ilişki tartışmalı olmakla birlikte çölyak hastalığı patogenezinde H. pylori’nin rolünü değerlendirmek için çok merkezli çalışmalara ihtiyaç vardır.

Keywords

Çölyak Hastalığı, H. Pylori, Prevalans

Ethical Statement

This study was performed in line with the principles of the Declaration of Helsinki. Approval was obtained from the Institutional Review Board of Adıyaman University Faculty of Medicine.

Supporting Institution

No financial support was received for this study from a person or organization.

References

• Lebwohl B, Sanders DS, Green PHR. Coeliac disease. Lancet. 2018;391(10115):70-81.
• Sahin Y. Celiac disease in children: A review of the literature. World J Clin Pediatr. 2021 Jul 9;10(4):53-71.
• Veres G, Pehlivanoglu E. Helicobacter pylori infection in pediatrics. Helicobacter. 2007;12 Suppl 1:38-44.
• Smyk DS, Koutsoumpas AL, Mytilinaiou MG, Rigopoulou EI, Sakkas LI, Bogdanos DP. Helicobacter pylori and autoimmune disease: cause or bystander. World J Gastroenterol. 2014;20(3):613-629.
• Broide E, Sandbank J, Scapa E, Kimchi NA, Shapiro M, Lerner A. The immunohistochemistry profile of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and inflammation. Mediators Inflamm. 2007;2007:81838.
• Green PH, Cellier C. Celiac disease. N Engl J Med. 2007;357(17):1731-1743.
• Sahin Y, Gubur O, Tekingunduz E. Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children. Arch Argent Pediatr. 2020 Jun;118(3):e241-e245.
• Villanacci V, Bassotti G, Liserre B, Lanzini A, Lanzarotto F, Genta RM. Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol. 2006;101(8):1880-1885.
• Konturek PC, Karczewska E, Dieterich W, Hahn EG, Schuppan D. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol. 2000;95(12):3682-3683.
• Ciacci C, Squillante A, Rendina D, et al. Helicobacter pylori infection and peptic disease in coeliac disease. Eur J Gastroenterol Hepatol. 2000;12(12):1283-1287.
• Luzza F, Mancuso M, Imeneo M, et al. Helicobacter pylori infection in children with celiac disease: prevalence and clinicopathologic features. J Pediatr Gastroenterol Nutr. 1999;28(2):143-146.
• Rostami Nejad M, Rostami K, Yamaoka Y, et al. Clinical and histological presentation of Helicobacter pylori and gluten related gastroenteropathy. Arch Iran Med. 2011;14(2):115-118.
• Jozefczuk J, Bancerz B, Walkowiak M, et al. Prevalence of Helicobacter pylori infection in pediatric celiac disease. Eur Rev Med Pharmacol Sci. 2015;19(11):2031-2035.
• Pişkinpaşa, N. (2021). Çölyak Hastalığının Sıklık Artışında Helicobacter Pylori’nin Etkisi. STED/Sürekli Tıp Eğitimi Dergisi, 30(1), 32-35.
• Crabtree JE, O'Mahony S, Wyatt JI, et al. Helicobacter pylori serology in patients with coeliac disease and dermatitis herpetiformis. J Clin Pathol. 1992;45(7):597-600.
• Lebwohl B, Blaser MJ, Ludvigsson JF, et al. Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol. 2013;178(12):1721-1730.
• Narang M, Puri AS, Sachdeva S, Singh J, Kumar A, Saran RK. Celiac disease and Helicobacter pylori infection in children: Is there any Association?. J Gastroenterol Hepatol. 2017;32(6):1178-1182.
• Yue M, Chen Q, Zhou X, Li L, Lu C. Is Helicobacter pylori Infection Associated with Celiac Disease? A Meta-analysis. Turk J Gastroenterol. 2022;33(3):205-212.
• Aksoy, E. K., Sapmaz, F., Akpınar, M. Y., & Uzman, M. (2018). Çölyak Hastalığında Helicobacter Pylori Prevalansının Değerlendirilmesi. Akademik Gastroenteroloji Dergisi, 17(1), 12-17.