The effect of tumor laterality on prognosis in metastatic renal cell carcinoma

Year 2024, Volume: 10 Issue: 2, 134 - 139, 30.08.2024

Özlem Doğan , Hayriye Şahinli , Yakup Duzkopru , Perihan Perkin , Esra Zeynelgil

https://doi.org/10.30569/adiyamansaglik.1446010

Abstract

Aim: In metastatic renal cell carcinoma (RCC), prognosis relies on various factors. Tumor lateralization's role is still debated. Our study examined how tumor localization affects survival in metastatic RCC patients.Materials and Methods: The study retrospectively analyzed 80 patients with metastatic renal cell carcinoma, diagnosed between January 1999 and December 2021.
Results: Eighty patients were evaluated. The median age at diagnosis was 60 (range 37-86). Tumors were in the right kidney for 39 patients (48.8%) and in the left kidney for 41 patients (51.2%). Of these patients, 58 (72.5%) had de novo metastatic disease, while 22 (27.5%) had recurrences during follow-up. Tumor localization showed no significant association with age (p=0.684), gender (p=0.761), ECOG performance status (p=0.326), primary tumor surgery (p=0.697), or lung metastasis (p=0.495). However, a significant association was found with liver metastasis (p=0.032). There was no significant difference in median survival between right and left-sided tumors (p=0.266).
Conclusion: In our study, survival showed no correlation with tumor lateralization in metastatic RCC.

Keywords

Renal cell carcinoma, Lateralization, Metastazis, Kidney

Ethical Statement

The study was conducted according to the principles of the Helsinki Declaration and was approved by the Ankara Etlik City Hospital Ethics Committee on April 5, 2023, with approval number 2023-043.

Supporting Institution

The authors received no financial support for the research and/or authorship of this article.

Thanks

None

Metastatik renal hücreli karsinomda tümör lateralitesinin prognoza etkisi

Abstract

Amaç: Metastatik renal hücreli kanserlerde (RCC) prognoz prognostik faktörlere bağlıdır. Tümör lateralizasyonun bu faktörlerden biri olup olmadığı halen tartışmalıdır. Çalışmamızda metastatik RCC ile takip edilen hastalarda tümörün yerleşiminin sağkalım üzerine etkisini araştırdık.
Gereç ve Yöntem: Çalışmada Ocak 1999 ve Aralık 2021 arasında metastatik renal hücreli kanser tanısı alan 80 hasta retrospektif olarak incelendi.
Bulgular: 80 hasta değerlendirildi. Median tanı yaşı 60 (37-86) idi. 39 (%48,8) hastada tümör sağ böbrekte, 41(%51,2) hastada sol böbrekte idi. Hastaların 58’i (%72,5) denova metastatik iken 22 (%27,5) hastada takipte nüks gelişmişti. Tümör lokalizasyonu ile yaş (p=0.684), cinsiyet (p=0.761), ECOG ps (p=0.326), tümör primerine cerrahi yapılması (p=0.697) ve akciğer metastazı (p=0.495) arasında anlamlı ilişki yokken, karaciğer metastazı arasında anlamlı ilişki saptandı (p=0.032). Sağ ve sol lokalizasyonlu tümör arasında median sağkalım açısından anlamlı fark yoktu (p=0.266).
Sonuç: Çalışmamızda, metastatik RCC'de sağkalım ile tümör lateralizasyonu arasınd ilişki bulunamadı.

Keywords

Renal hücreli karsinom, Lateralizasyon, Metastaz, Böbrek

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