Corrected TLC-Data of 61 Benzodiazepines and Metabolites In Two Systems*

Year 1985, Volume: 1 Issue: 1, 22 - 29, 30.04.1985

Arald Schütz

https://izlik.org/JA46TE38KU

Abstract

Since the discovery of chlordiazepoxide (Librium) in 1957 the benzodiazepines have had
a tremendous impact on the treatment of disorders of nervous origin. These drugs have become
among the most widely prescribed in medicine and referred to in the analytical literature.
Many other benzodiazėpines have also been introduced. In this work we have determined the
thin - layer chromatographic properties of 61 important 1,4- and 1,5- benzodiazepines respectively and metabolites on the base of corrected Rf - values which are calculated according
to the procedure reported by Franke and De Zeeuw.

Keywords

benzodiazepines , TLC-Data , Systems

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