Corrected TLC-Data of 61 Benzodiazepines and Metabolites In Two Systems*

Yıl 1985, Cilt: 1 Sayı: 1, 22 - 29, 30.04.1985

Arald Schütz

https://izlik.org/JA46TE38KU

Öz

Since the discovery of chlordiazepoxide (Librium) in 1957 the benzodiazepines have had
a tremendous impact on the treatment of disorders of nervous origin. These drugs have become
among the most widely prescribed in medicine and referred to in the analytical literature.
Many other benzodiazėpines have also been introduced. In this work we have determined the
thin - layer chromatographic properties of 61 important 1,4- and 1,5- benzodiazepines respectively and metabolites on the base of corrected Rf - values which are calculated according
to the procedure reported by Franke and De Zeeuw.

Anahtar Kelimeler

benzodiazepines , TLC-Data , Systems

Kaynakça

• Schütz, H. (1982) Benzodiazepines - A Handbook, Springer - Verlag, Berlin, Heidel- berg, New York, Tokyo.
• Franke, J.P. (Personal communication).
• De Zeeuw, R.A., Schepers, P., Greving, J.E. and Franke, J.P. (1978) Proc. Intern. Symp. Instrumental Applications in Forensic Drug Chemistry, May 29 - 30, Washington, DC.
• Galanos, D.S. and Kapoulas, V.M. (1964) J. Chromatogr., 13, 128.
• Machata, G. (Personal communication).
• Akkerboom, J. C., Schepers, P., v.d. Werff, J. (1980) Statistica Neerlandica, 34, 173.1029
• Dhont, J.H., Vinkenborg, C., Compaarn, H., Ritter, F.J., Labadie, R.P., Verweij, A., de Zeeuw, R.A. (1970) J. Chromatogr, 47, 376.
• Dhont, J.H., Vinkenborg, C., Compaarn, H., Ritter, F.J., Labadie, R.P., Verweij, A., de Zeeuw, R.A. (1972) J. Chromatogr., 71, 283.
• Enders, P. (Personal communication).- Schütz, H. (1978) J. Anal. Toxicol., 2, 147 - 148.
• Schütz, H. (1979) Z. Anal. Chem., 294: 135-139.
• Schütz, H. (1978) Z. Rechtsmed., 82, 43 - 53. 15
• Schütz, H. and Westenberger, V. (1979)
• Schütz, H. (1982) Arztl. Lab., 28, 117- 132. - Schütz, H. (1980) Arztl. Lab., 26, 83-88. J. Chromatogr., 169, 409 -411.
• Schütz, H. (1983) Alkohol im Blut, Nachweis und Bestimmung, rechnung. Verlag Chemie, Weinheim, Deerfield Beach, Basel.