Corrected TLC-Data of 61 Benzodiazepines and Metabolites In Two Systems*

Öz

Since the discovery of chlordiazepoxide (Librium) in 1957 the benzodiazepines have had a tremendous impact on the treatment of disorders of nervous origin. These drugs have become among the most widely prescribed in medicine and referred to in the analytical literature. Many other benzodiazėpines have also been introduced. In this work we have determined the thin - layer chromatographic properties of 61 important 1,4- and 1,5- benzodiazepines respectively and metabolites on the base of corrected Rf - values which are calculated according to the procedure reported by Franke and De Zeeuw.

Anahtar Kelimeler

• benzodiazepines
• TLC-Data
• Systems

Kaynakça

1. Schütz, H. (1982) Benzodiazepines - A Handbook, Springer - Verlag, Berlin, Heidel- berg, New York, Tokyo.
2. Franke, J.P. (Personal communication).
3. De Zeeuw, R.A., Schepers, P., Greving, J.E. and Franke, J.P. (1978) Proc. Intern. Symp. Instrumental Applications in Forensic Drug Chemistry, May 29 - 30, Washington, DC.
4. Galanos, D.S. and Kapoulas, V.M. (1964) J. Chromatogr., 13, 128.
5. Machata, G. (Personal communication).
6. Akkerboom, J. C., Schepers, P., v.d. Werff, J. (1980) Statistica Neerlandica, 34, 173.1029
7. Dhont, J.H., Vinkenborg, C., Compaarn, H., Ritter, F.J., Labadie, R.P., Verweij, A., de Zeeuw, R.A. (1970) J. Chromatogr, 47, 376.
8. Dhont, J.H., Vinkenborg, C., Compaarn, H., Ritter, F.J., Labadie, R.P., Verweij, A., de Zeeuw, R.A. (1972) J. Chromatogr., 71, 283.

9. Enders, P. (Personal communication).- Schütz, H. (1978) J. Anal. Toxicol., 2, 147 - 148.
10. Schütz, H. (1979) Z. Anal. Chem., 294: 135-139.
11. Schütz, H. (1978) Z. Rechtsmed., 82, 43 - 53. 15
12. Schütz, H. and Westenberger, V. (1979)
13. Schütz, H. (1982) Arztl. Lab., 28, 117- 132. - Schütz, H. (1980) Arztl. Lab., 26, 83-88. J. Chromatogr., 169, 409 -411.
14. Schütz, H. (1983) Alkohol im Blut, Nachweis und Bestimmung, rechnung. Verlag Chemie, Weinheim, Deerfield Beach, Basel.