ADULTERATION OF URINE DRUG TESTING: CASE REPORT AND REVIEW

Year 2013, Volume: 27 Issue: 3, 103 - 106, 31.12.2013

Faruk Aşıcıoğlu Zeynep Orhan

https://izlik.org/JA76FA93LD

Abstract

Drug tests are conducted for individuals having suspected intoxication, having suspected drug
use, involving in an accident,
being in probation control; applicants during recruitment and
prisoners. However, the validity of
these tests depend on the urine
sample’s being uninterferenced.
Because, illicit drug users add
easily available common foreign substances(adulterants) into
the urine to deceive these tests.
Adulterants are classified into
two categories. The first category includes classic adulterants
comprising of some household
chemicals such as chlorine bleach, white vinegar, glutaraldehyde, liquid drain cleaner, sodium
nitrite, pyridinium chlorochromate. The second category includes
commercial products which can
be purchased from certain specialty stores or via internet.
Dilution of urine by means of
excess water intake is the most
basic method used for adulteration. The case we present
tried to falsify the result two
times by drinking water and
once by giving the urine of a different person for the analysis.
Adulterant use can be disclosed by presumptive tests such
as specific gravity, pH, temperature, creatinine, nitrite, glutaraldehyde levels which are
useful for determining whether
the urine sample is interferenced or not. Urine dilution in our
case is disclosed by the abnormal creatinine concentration of
less than 20 mg/dL. This case
was presented to draw attention for adulterant use which is
not common and well known by
scientists in Turkey.

Keywords

adulterant , adulteration , urine integrity , drug test

References

• WongR. The effect of adulterants on urine screen for drugsof abuse: Detection by an on-site dipstick device. Am Clin Lab 2002;21(1)37-9.
• Mikkelsen SL, Ash KO. Adulterants causing false negative in illicit drug test. Clin Chem 1988;34(11):2333-36.
• Denetimli Serbestlik ve Yardım Merkezleri İle Koruma Kurulları Yönetmeliği (18/04/2007 tarih, 2007/26497 sayılı Resmi Gazete).
• Dasgupta A, Wahed A, Wells A. Rapid spot tests for detecting the presence of adulterants in urine specimens submitted for drug testing. Am J Clin Pathol 2002;117(2):325-29.
• Burrows DL, Nicolaides A, Rice PJ, Dufforc M, Johnson DA, Ferslew KE. Papain: a novel urine adulterant. J Anal Toxicol 2005;29(5):275-95.
• Warner A. Interference of household chemicals in immunoassay methods for drugs of abuse. Clin Chem 1989;35(4):648-51
• Baiker C, Serrano L, Lindner B. Hypochlorite adulteration of urine causing decreased concentration of delta 9-THC-COOH by GC/MS. J Anal Toxicol 1994;18(2):101-3.
• U.S.Dept. of Health and Human Services. Mandatory Guidelines for Federal Workplace Drug Testing Programs: Final Guidelines Notice. Fed Reg 1988;53:11969-89
• Cone EJ, Lange R, Darwin WD. In vivo adulteration: excess fluid ingestion causes falsenegative marijuana and cocaine urine test results. J Anal Toxicol 1998;22(6):460-73.
• Wu A. Integrity of urine specimens submitted for toxicological analysis: adulteration, mechanism of action and laboratory detection. Forensic Sci Rev 1998;10:47-65
• U.S.Dept. of Health and Human Services. Mandatory Guidelines for Federal Workplace Drug Testing Programs: Notice of Proposed Revision. Fed Reg 2001;66:43876-82
• ElSohly MA, Feng S, Kopycki WJ, et al. A procedure to overcome interference caused by the adulterant “Klear” in the GC-MS analysis of 11-nor-Delta9-THC-9-COOH. J Anal Toxicol 1997;21(3):240-42.
• Tsai SC, ElSohly MA, Dubrovsky T, et al. Determination of five abused drugs in nitriteadulterated urine by immunoassay and gas chromatography-mass spectrometry. J Anal Toxicol 1998;22(6):474-80.
• Tsai LS, ElSohly MA, Tsai SF, Murphy TP, Twarowska B, Salamone SJ. Investigation of nitrite adulteration on the immunoassay and GC-MS analysis of cannabinoids in urine specimens. J Anal Toxicol 2000;24(8):708-14.
• Tai Hl, Chan MHM, Lee DTS, Ng KF, Law ELK, Lam CWK. Urine adulteration in drug testing. Hong Kong J Psychiatry 2005:60-2.
• 5996 sayılı Veteriner Hizmetleri, Bitki Sağlığı, Gıda ve Yem Kanunu. Kabul tarihi: 11.06.2010.
• George S, Braithwaite RA. An investigation in to the extent of possible dilution of specimens received for urinary drugs of abuse screening. Addiction 1995;90(7):967-70.
• Ropero-Miller JD, Paget-Wilkes H, Doering PL, Goldberger BA. Effect of Oral Creatine Supplemantation on Random Urine creatinine, pH, and specific gravity measurements. Clin Chem 2000;46(2):295-97.