Evaluation the Relationship Between Periodontal Disease and Inflammatory Bowel Diseases by Emphasizing the Role of Cytokines

Yıl 2021, Cilt: 10 Sayı: 2, 143 - 149, 25.05.2021

Ayaz Enver , Nurdan Özmeriç

Öz

Periodontal disease is a local, chronic and inflammatory process that resulted from a complex interactions between biofilm and inflammatory immune response. Biofilm infections generally cause simultaneous activation of both natural and adaptive immune responses. Inflammatory bowel diseases characterized by chronic inflammation in the intestines with exacerbations and remissions. Although the etiopathogenesis is not fully known, it is suggested that the disease is caused by chronic immune-mediated intestinal damage as a result of the complex interaction of genetic susceptibility and endogenous and exogenous triggers. Cytokines take a place in many events including proliferation, growth, differentiation, hemostasis, regeneration, repair and inflammation. We aim in this review to evaluate the studies dealing with periodontal disease, inflammatory bowel diseases and their relation by emphasizing the role of cytokines.
Keywords: Cytokines; Inflammatory bowel diseases; Periodontal disease.

Anahtar Kelimeler

Cytokines, Inflammatory Bowel Diseases, Periodontal Diseases

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Periodontal Hastalık ve İnflamatuar Bağırsak Hastalıkları Arasındaki İlişkinin, Sitokinlerin Rolünü Vurgulayarak Değerlendirilmesi

Öz

Periodontal hastalık, biyofilm ve inflamatuar immün yanıt arasındaki komplike etkileşimlerden kaynaklanan lokal, kronik ve inflamatuar yanıttır. Biyofilm enfeksiyonları genellikle hem doğal hem de kazanılmış immün yanıtlarında aktivasyonuna neden olur. Inflamatuar bağırsak hastalıkları, Aktivasyon ve remesyonla birlikte bağırsaklarda kronik inflamasyon ile karakterizedir. Etiyopatogenezi tam olarak bilinmemekle birlikte, hastalığa genetik yatkınlık ile endojen ve ekzojen tetikleyicilerin komplike etkileşiminin bir sonucu olarak kronik immün aracılı bağırsak hasarından kaynaklandığı ileri sürülmektedir. Sitokinler, proliferasyon, büyüme, farklılaşma, hemostaz, rejenerasyon, onarım ve inflamasyon gibi birçok olayda yer alır. Bu derlemede, sitokinlerin rolünü vurgulayarak periodontal hastalık, inflamatuar bağırsak hastalıkları ve bunların ilişkisini ele alan çalışmaları değerlendirmeyi amaçlamaktayız.
Anahtar Kelimeler: Sitokinler; Inflamatuar bağırsak hastalıkları; Periodontal hastalık.

Anahtar Kelimeler

Sitokinler, Inflammatory Bowel Diseases, Periodontal Disease

Proje Numarası

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Kaynakça

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