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Periodontal Tedavilerde Amelogenin (Emdogain) ve Mineralizan Peptid Uygulamaları

Year 2022, Volume: 11 Issue: 1, 97 - 102, 17.01.2022
https://doi.org/10.54617/adoklinikbilimler.907103

Abstract

Periodontal hastalıklar sonucunda ortaya çıkan defektleri iyileştirmek amacıyla ortaya konan çözümlerin yeterli olmaması sebebiyle; araştırmalar defekt bölgelerine uygulanabilecek yeni ajanlar geliştirmeye yönelmiştir. En umut verici çalışmaların Emdogain ve mineralizan peptitler kullanılarak yapıldığı görülmüştür. Bu derleme Emdogain ve mineralizan peptitlerin periodontal defektlere uygulanması ile oluşan sonuçları ve hangi bölgelerde kullanım alanları olduğunu inceleyen çalışmalardan oluşmaktadır.

References

  • 1.LeGeros RZ. Calcium phosphates in oral biology and medicine. Monogr Oral Sci. 1991;15:1-201.
  • 2. Gajjeraman S, Narayanan K, Hao J, Qin C, George A. Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem. 2007 Jan 12;282(2):1193-204.
  • 3.Lowenstam, H. A., & Weiner, S. On biomineralization: Oxford University Press on Demand. 1989 324\335
  • 4.Mann, S. Biomineralization: principles and concepts in bioinorganic materials chemistry (Vol. 5): Oxford University Press on Demand. 2001
  • 5.Taubman MA, Valverde P, Han X, Kawai T. Immune response: the key to bone resorption in periodontal disease. J Periodontol. 2005 Nov;76(11 Suppl):2033-41.
  • 6.Gu LS, Kim YK, Liu Y, Takahashi K, Arun S, Wimmer CE, et al. Immobilization of a phosphonated analog of matrix phosphoproteins within cross-linked collagen as a templating mechanism for biomimetic mineralization. Acta Biomater. 2011 Jan;7(1):268-77.
  • 7.Kim J, Arola DD, Gu L, Kim YK, Mai S, Liu Y, et al. Functional biomimetic analogs help remineralize apatite-depleted demineralized resin-infiltrated dentin via a bottom-up approach. Acta Biomater. 2010 Jul;6(7):2740-50.
  • 8.Heijl L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol. 1997 Sep;24(9 Pt 2):693-6.
  • 9.Heijl L, Heden G, Svärdström G, Ostgren A. Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol. 1997 Sep;24(9 Pt 2):705-14.
  • 10.Esposito M, Coulthard P, Thomsen P, Worthington HV. Enamel matrix derivative for periodontal tissue regeneration in treatment of intrabony defects: a Cochrane systematic review. J Dent Educ. 2004 Aug;68(8):834-44.
  • 11.Heden G, Wennström JL. Five-year follow-up of regenerative periodontal therapy with enamel matrix derivative at sites with angular bone defects. J Periodontol. 2006 Feb;77(2):295-301.
  • 12.Fincham AG, Moradian-Oldak J, Simmer JP, Sarte P, Lau EC, Diekwisch T, et al. Self-assembly of a recombinant amelogenin protein generates supramolecular structures. J Struct Biol. 1994 Mar-Apr;112(2):103-9.
  • 13.Gestrelius S, Andersson C, Johansson AC, Persson E, Brodin A, Rydhag L, et al. Formulation of enamel matrix derivative for surface coating. Kinetics and cell colonization. J Clin Periodontol. 1997 Sep;24(9 Pt 2):678-84.
  • 14.Gaskin, D. J., Starck, K., & Vulfson, E. N. Identification of inorganic crystal-specific sequences using phage display combinatorial library of short peptides: a feasibility study. Biotechnology Letters, 2000 22(15), 1211-1216.
  • 15.Gungormus M, Fong H, Kim IW, Evans JS, Tamerler C, Sarikaya M. Regulation of in vitro calcium phosphate mineralization by combinatorially selected hydroxyapatite-binding peptides. Biomacromolecules. 2008 Mar;9(3):966-73.
  • 16.Nayebi N, Cetinel S, Omar SI, Tuszynski JA, Montemagno C. A computational method for selecting short peptide sequences for inorganic material binding. Proteins. 2017 Nov;85(11):2024-35.
  • 17.Sawada, T., Asada, M., & Serizawa, T. Selective rare earth recovery employing filamentous viruses with chemically conjugated peptides. ChemistrySelect, 2016 1(11), 2712-2716.
  • 18.Le Norcy E, Kwak SY, Wiedemann-Bidlack FB, Beniash E, Yamakoshi Y, Simmer JP, et al. Leucine-rich amelogenin peptides regulate mineralization in vitro. J Dent Res. 2011 Sep;90(9):1091-7
  • 19. Shaw WJ, Campbell AA, Paine ML, Snead ML. The COOH terminus of the amelogenin, LRAP, is oriented next to the hydroxyapatite surface. J Biol Chem. 2004 Sep 24;279(39):40263-6.
  • 20.Li W, Gao C, Yan Y, DenBesten P. X-linked amelogenesis imperfecta may result from decreased formation of tyrosine rich amelogenin peptide (TRAP). Arch Oral Biol. 2003 Mar;48(3):177-83.
  • 21.Gungormus M, Oren EE, Horst JA, Fong H, Hnilova M, Somerman MJ, et al. Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides. Int J Oral Sci. 2012 Jun;4(2):69-77.
  • 22.Gungormus M, Ozdogan MS, Ertem SY, Tulumbaci F, Kara H, Orhan M. Accelerated Calcium Phosphate Mineralization by Peptides with Adjacent Oppositely Charged Residues. ACS Biomater Sci Eng. 2020 07 13;6(7):3791-8.
  • 23.Gungormus M, Tulumbaci F. Peptide-assisted pre-bonding remineralization of dentin to improve bonding. J Mech Behav Biomed Mater. 2021 01;113:104119.
  • 24.Hammarström L, Blomlöf L, Lindskog S. Dynamics of dentoalveolar ankylosis and associated root resorption. Endod Dent Traumatol. 1989 Aug;5(4):163-75.
  • 25.Okuda K, Momose M, Miyazaki A, Murata M, Yokoyama S, Yonezawa Y, et al. Enamel matrix derivative in the treatment of human intrabony osseous defects. J Periodontol. 2000 Dec;71(12):1821-8.
  • 26.Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Burns DM. Enamel matrix derivative (EMDOGAIN) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodontal Res. 2001 Dec;36(6):367-76.
  • 27.Lyngstadaas SP, Lundberg E, Ekdahl H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol. 2001 Feb;28(2):181-8.
  • 28.He J, Jiang J, Safavi KE, Spångberg LS, Zhu Q. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Feb;97(2):239-45.
  • 29.Warotayanont R, Zhu D, Snead ML, Zhou Y. Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. Biochem Biophys Res Commun. 2008 Feb 29;367(1):1-6.
  • 30.Kawana F, Sawae Y, Sahara T, Tanaka S, Debari K, Shimizu M, et al. Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur. Anat Rec. 2001 12 1;264(4):438-46.
  • 31.Rathe F, Junker R, Chesnutt BM, Jansen JA. The effect of enamel matrix derivative (Emdogain) on bone formation: a systematic review. Tissue Eng Part B Rev. 2009 Sep;15(3):215-24.
  • 32.Shimizu-Ishiura M, Tanaka S, Lee WS, Debari K, Sasaki T. Effects of enamel matrix derivative to titanium implantation in rat femurs. J Biomed Mater Res. 2002 May;60(2):269-76.
  • 33.Myhre AE, Lyngstadaas SP, Dahle MK, Stuestøl JF, Foster SJ, Thiemermann C, et al. Anti-inflammatory properties of enamel matrix derivative in human blood. J Periodontal Res. 2006 Jun;41(3):208-13.
  • 34.Spahr A, Lyngstadaas SP, Boeckh C, Andersson C, Podbielski A, Haller B. Effect of the enamel matrix derivative Emdogain on the growth of periodontal pathogens in vitro. J Clin Periodontol. 2002 Jan;29(1):62-72.
  • 35.Sculean A, Schwarz F, Becker J, Brecx M. The application of an enamel matrix protein derivative (Emdogain) in regenerative periodontal therapy: a review. Med Princ Pract. 2007;16(3):167-80.36.Yukna R, Salinas TJ, Carr RF. Periodontal regeneration following use of ABM/P-1 5: a case report. Int J Periodontics Restorative Dent. 2002 Apr;22(2):146-55.
  • 36.Nguyen H, Qian JJ, Bhatnagar RS, Li S. Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels. Biochem Biophys Res Commun. 2003 Nov 7;311(1):179-86.
  • 37.Yukna R, Salinas TJ, Carr RF. Periodontal regeneration following use of ABM/P-1 5: a case report. Int J Periodontics Restorative Dent. 2002 Apr;22(2):146-55.
  • 38.Kestle JR. Editorial: Food and Drug Administration Safety Communication on rhBMP-2 use. J Neurosurg Pediatr. 2015 Jul;16(1):1-3.
  • 39.Correa R, Arenas J, Montoya G, Hoz L, López S, Salgado F, et al. Synthetic cementum protein 1-derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo. FASEB J. 2019 01;33(1):1167-78.
  • 40.Boabaid F, Gibson CW, Kuehl MA, Berry JE, Snead ML, Nociti FH, et al. Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol. 2004 Aug;75(8):1126-36.
  • 41.Das EC, Dhawan S, Babu J, Anil Kumar PR, Kumary TV, Haridas V, et al. Self-assembling polymeric dendritic peptide as functional osteogenic matrix for periodontal regeneration scaffolds-an in vitro study. J Periodontal Res. 2019 Oct;54(5):468-80
  • 42.Kitagawa M, Kitagawa S, Nagasaki A, Miyauchi M, Uchida T, Takata T. Synthetic ameloblastin peptide stimulates differentiation of human periodontal ligament cells. Arch Oral Biol. 2011 Apr;56(4):374-9.
Year 2022, Volume: 11 Issue: 1, 97 - 102, 17.01.2022
https://doi.org/10.54617/adoklinikbilimler.907103

Abstract

References

  • 1.LeGeros RZ. Calcium phosphates in oral biology and medicine. Monogr Oral Sci. 1991;15:1-201.
  • 2. Gajjeraman S, Narayanan K, Hao J, Qin C, George A. Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite. J Biol Chem. 2007 Jan 12;282(2):1193-204.
  • 3.Lowenstam, H. A., & Weiner, S. On biomineralization: Oxford University Press on Demand. 1989 324\335
  • 4.Mann, S. Biomineralization: principles and concepts in bioinorganic materials chemistry (Vol. 5): Oxford University Press on Demand. 2001
  • 5.Taubman MA, Valverde P, Han X, Kawai T. Immune response: the key to bone resorption in periodontal disease. J Periodontol. 2005 Nov;76(11 Suppl):2033-41.
  • 6.Gu LS, Kim YK, Liu Y, Takahashi K, Arun S, Wimmer CE, et al. Immobilization of a phosphonated analog of matrix phosphoproteins within cross-linked collagen as a templating mechanism for biomimetic mineralization. Acta Biomater. 2011 Jan;7(1):268-77.
  • 7.Kim J, Arola DD, Gu L, Kim YK, Mai S, Liu Y, et al. Functional biomimetic analogs help remineralize apatite-depleted demineralized resin-infiltrated dentin via a bottom-up approach. Acta Biomater. 2010 Jul;6(7):2740-50.
  • 8.Heijl L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol. 1997 Sep;24(9 Pt 2):693-6.
  • 9.Heijl L, Heden G, Svärdström G, Ostgren A. Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol. 1997 Sep;24(9 Pt 2):705-14.
  • 10.Esposito M, Coulthard P, Thomsen P, Worthington HV. Enamel matrix derivative for periodontal tissue regeneration in treatment of intrabony defects: a Cochrane systematic review. J Dent Educ. 2004 Aug;68(8):834-44.
  • 11.Heden G, Wennström JL. Five-year follow-up of regenerative periodontal therapy with enamel matrix derivative at sites with angular bone defects. J Periodontol. 2006 Feb;77(2):295-301.
  • 12.Fincham AG, Moradian-Oldak J, Simmer JP, Sarte P, Lau EC, Diekwisch T, et al. Self-assembly of a recombinant amelogenin protein generates supramolecular structures. J Struct Biol. 1994 Mar-Apr;112(2):103-9.
  • 13.Gestrelius S, Andersson C, Johansson AC, Persson E, Brodin A, Rydhag L, et al. Formulation of enamel matrix derivative for surface coating. Kinetics and cell colonization. J Clin Periodontol. 1997 Sep;24(9 Pt 2):678-84.
  • 14.Gaskin, D. J., Starck, K., & Vulfson, E. N. Identification of inorganic crystal-specific sequences using phage display combinatorial library of short peptides: a feasibility study. Biotechnology Letters, 2000 22(15), 1211-1216.
  • 15.Gungormus M, Fong H, Kim IW, Evans JS, Tamerler C, Sarikaya M. Regulation of in vitro calcium phosphate mineralization by combinatorially selected hydroxyapatite-binding peptides. Biomacromolecules. 2008 Mar;9(3):966-73.
  • 16.Nayebi N, Cetinel S, Omar SI, Tuszynski JA, Montemagno C. A computational method for selecting short peptide sequences for inorganic material binding. Proteins. 2017 Nov;85(11):2024-35.
  • 17.Sawada, T., Asada, M., & Serizawa, T. Selective rare earth recovery employing filamentous viruses with chemically conjugated peptides. ChemistrySelect, 2016 1(11), 2712-2716.
  • 18.Le Norcy E, Kwak SY, Wiedemann-Bidlack FB, Beniash E, Yamakoshi Y, Simmer JP, et al. Leucine-rich amelogenin peptides regulate mineralization in vitro. J Dent Res. 2011 Sep;90(9):1091-7
  • 19. Shaw WJ, Campbell AA, Paine ML, Snead ML. The COOH terminus of the amelogenin, LRAP, is oriented next to the hydroxyapatite surface. J Biol Chem. 2004 Sep 24;279(39):40263-6.
  • 20.Li W, Gao C, Yan Y, DenBesten P. X-linked amelogenesis imperfecta may result from decreased formation of tyrosine rich amelogenin peptide (TRAP). Arch Oral Biol. 2003 Mar;48(3):177-83.
  • 21.Gungormus M, Oren EE, Horst JA, Fong H, Hnilova M, Somerman MJ, et al. Cementomimetics-constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides. Int J Oral Sci. 2012 Jun;4(2):69-77.
  • 22.Gungormus M, Ozdogan MS, Ertem SY, Tulumbaci F, Kara H, Orhan M. Accelerated Calcium Phosphate Mineralization by Peptides with Adjacent Oppositely Charged Residues. ACS Biomater Sci Eng. 2020 07 13;6(7):3791-8.
  • 23.Gungormus M, Tulumbaci F. Peptide-assisted pre-bonding remineralization of dentin to improve bonding. J Mech Behav Biomed Mater. 2021 01;113:104119.
  • 24.Hammarström L, Blomlöf L, Lindskog S. Dynamics of dentoalveolar ankylosis and associated root resorption. Endod Dent Traumatol. 1989 Aug;5(4):163-75.
  • 25.Okuda K, Momose M, Miyazaki A, Murata M, Yokoyama S, Yonezawa Y, et al. Enamel matrix derivative in the treatment of human intrabony osseous defects. J Periodontol. 2000 Dec;71(12):1821-8.
  • 26.Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Burns DM. Enamel matrix derivative (EMDOGAIN) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodontal Res. 2001 Dec;36(6):367-76.
  • 27.Lyngstadaas SP, Lundberg E, Ekdahl H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol. 2001 Feb;28(2):181-8.
  • 28.He J, Jiang J, Safavi KE, Spångberg LS, Zhu Q. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Feb;97(2):239-45.
  • 29.Warotayanont R, Zhu D, Snead ML, Zhou Y. Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. Biochem Biophys Res Commun. 2008 Feb 29;367(1):1-6.
  • 30.Kawana F, Sawae Y, Sahara T, Tanaka S, Debari K, Shimizu M, et al. Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur. Anat Rec. 2001 12 1;264(4):438-46.
  • 31.Rathe F, Junker R, Chesnutt BM, Jansen JA. The effect of enamel matrix derivative (Emdogain) on bone formation: a systematic review. Tissue Eng Part B Rev. 2009 Sep;15(3):215-24.
  • 32.Shimizu-Ishiura M, Tanaka S, Lee WS, Debari K, Sasaki T. Effects of enamel matrix derivative to titanium implantation in rat femurs. J Biomed Mater Res. 2002 May;60(2):269-76.
  • 33.Myhre AE, Lyngstadaas SP, Dahle MK, Stuestøl JF, Foster SJ, Thiemermann C, et al. Anti-inflammatory properties of enamel matrix derivative in human blood. J Periodontal Res. 2006 Jun;41(3):208-13.
  • 34.Spahr A, Lyngstadaas SP, Boeckh C, Andersson C, Podbielski A, Haller B. Effect of the enamel matrix derivative Emdogain on the growth of periodontal pathogens in vitro. J Clin Periodontol. 2002 Jan;29(1):62-72.
  • 35.Sculean A, Schwarz F, Becker J, Brecx M. The application of an enamel matrix protein derivative (Emdogain) in regenerative periodontal therapy: a review. Med Princ Pract. 2007;16(3):167-80.36.Yukna R, Salinas TJ, Carr RF. Periodontal regeneration following use of ABM/P-1 5: a case report. Int J Periodontics Restorative Dent. 2002 Apr;22(2):146-55.
  • 36.Nguyen H, Qian JJ, Bhatnagar RS, Li S. Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels. Biochem Biophys Res Commun. 2003 Nov 7;311(1):179-86.
  • 37.Yukna R, Salinas TJ, Carr RF. Periodontal regeneration following use of ABM/P-1 5: a case report. Int J Periodontics Restorative Dent. 2002 Apr;22(2):146-55.
  • 38.Kestle JR. Editorial: Food and Drug Administration Safety Communication on rhBMP-2 use. J Neurosurg Pediatr. 2015 Jul;16(1):1-3.
  • 39.Correa R, Arenas J, Montoya G, Hoz L, López S, Salgado F, et al. Synthetic cementum protein 1-derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo. FASEB J. 2019 01;33(1):1167-78.
  • 40.Boabaid F, Gibson CW, Kuehl MA, Berry JE, Snead ML, Nociti FH, et al. Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol. 2004 Aug;75(8):1126-36.
  • 41.Das EC, Dhawan S, Babu J, Anil Kumar PR, Kumary TV, Haridas V, et al. Self-assembling polymeric dendritic peptide as functional osteogenic matrix for periodontal regeneration scaffolds-an in vitro study. J Periodontal Res. 2019 Oct;54(5):468-80
  • 42.Kitagawa M, Kitagawa S, Nagasaki A, Miyauchi M, Uchida T, Takata T. Synthetic ameloblastin peptide stimulates differentiation of human periodontal ligament cells. Arch Oral Biol. 2011 Apr;56(4):374-9.
There are 42 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Derleme
Authors

Hikmet Anıl Kurun 0000-0003-0858-7056

Mustafa Güngörmüş This is me 0000-0001-8894-0467

Mazlum Bülent Kurtiş 0000-0002-1124-3097

Cenkhan Bal 0000-0002-1205-276X

Publication Date January 17, 2022
Submission Date April 4, 2021
Published in Issue Year 2022 Volume: 11 Issue: 1

Cite

Vancouver Kurun HA, Güngörmüş M, Kurtiş MB, Bal C. Periodontal Tedavilerde Amelogenin (Emdogain) ve Mineralizan Peptid Uygulamaları. ADO Klinik Bilimler Dergisi. 2022;11(1):97-102.