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Conservative Management of Mural Subtype Unicystic Ameloblastoma in Young Patient: A Case Report with One Year of Follow Up

Yıl 2025, Cilt: 14 Sayı: 1, 57 - 64, 27.01.2025
https://doi.org/10.54617/adoklinikbilimler.1532576

Öz

Introduction: Ameloblastoma is a benign tumor primarily found in the jawbone. Unicystic ameloblastoma comprises four distinct types, first categorized in 1977. The primary mode of treatment is surgical intervention. This case report details the surgical management of a 13-year-old boy diagnosed with unicystic ameloblastoma and an impacted left mandibular third molar during the COVID-19 pandemic.

Case Report: A 13-year-old boy was referred to the Oral and Maxillofacial Surgery Department at Hacettepe University due to a radiolucent lesion surrounding an impacted mandibular third molar, which led to facial asymmetry. The treatment plan included the extraction of the second molar, a biopsy, and marsupialization. During the one-year follow-up, no recurrence was noted.

Conclusion: Marsupialization, which involves creating an open pocket by suturing the edges of a lesion to the oral cavity or sinuses for fluid drainage, is a conservative treatment approach particularly suitable for young patients. This method preserves the growth potential of the bone, improves aesthetic outcomes, and protects vital structures. In this case, due to the COVID-19 pandemic, conservative treatment under local anesthesia was preferred, with enucleation performed after marsupialization. Such approaches address clinical needs effectively and support patients' psychological well-being during challenging periods like pandemics.

Kaynakça

  • Referans1. Soluk-Tekkesin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. Turk Patoloji Derg 2022;38:168-84.
  • Referans2. Robinson L, Martinez MG. Unicystic ameloblastoma: a prognostically distinct entity. Cancer 1977;40:2278-85.
  • Referans3. Poonja K, Galinde J, Dave PM. Unicystic Ameloblastoma. Journal of Contemporary Dentistry 2015;5:40-2.
  • Referans4. Philipsen HP, Reichart PA. Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol 1998;34:317-25.
  • Referans5. Garcia NG, Oliveira DT, Rodrigues MT. Unicystic Ameloblastoma with Mural Proliferation Managed by Conservative Treatment. Case Rep Pathol 2016;2016:3089540.
  • Referans6. Ooi A, Feng J, Tan HK, Ong YS. Primary treatment of mandibular ameloblastoma with segmental resection and free fibula reconstruction: achieving satisfactory outcomes with low implant-prosthetic rehabilitation uptake. J Plast Reconstr Aesthet Surg 2014;67:498-505.
  • Referans7. Hammarfjord O, Roslund J, Abrahamsson P, Nilsson P, Thor A, Magnusson M, et al. Surgical treatment of recurring ameloblastoma, are there options? Br J Oral Maxillofac Surg 2013;51:762-6.
  • Referans8. Lau SL, Samman N. Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review. Int J Oral Maxillofac Surg 2006;35:681-90.
  • Referans9. Nowair IM, Eid MK. A modified surgical approach for the treatment of mandibular unicystic ameloblastoma in young patients. J Craniomaxillofac Surg 2020;48:148-55.
  • Referans10. Zheng CY, Cao R, Hong WS, Sheng MC, Hu YJ. Marsupialisation for the treatment of unicystic ameloblastoma of the mandible: a long-term follow up of 116 cases. Br J Oral Maxillofac Surg 2019; 57:655-62
  • Referans11. Caldeira PC, Schuch LF, Tavares TS, Santos-Silva AR, Vargas PA, Pérez-de-Oliveira ME, et al. Impact of the COVID-19 pandemic on public University laboratories of oral and maxillofacial pathology: A Brazilian multicenter study. Oral Dis 2022;28:2423- 31.
  • Referans12. Maffia F, Fontanari M, Vellone V, Cascone P, Mercuri LG. Impact of COVID-19 on maxillofacial surgery practice: a worldwide survey. Int J Oral Maxillofac Surg 2020;49:827-35.
  • Referans13. Zheng C, Cao R, Hong W, Sheng M, Hu Y. Marsupialisation for the treatment of unicystic ameloblastoma of the mandible: a long-term follow up of 116 cases. British Journal of Oral and Maxillofacial Surgery 2019;57:655-62.
  • Referans14. Datarkar A, Rai A, Bhawalkar A, Jain A. Clinical outcome following conservative treatment of 58 mandibular ameloblastoma patients: a retrospective study. Oral Maxillofac Surg 2023;27:601- 8.
  • Referans15. Srikar M, Sangamesh N, Vidya K. Marsupialization for the Management of Unicystic Ameloblastoma-Retrospective Study. Indian Journal of Public Health 2020;11:593.
  • Referans16. Zhang X, Liu L, Yang X, Wang L, Zhang C, Hu Y. Expression of TP53 and IL-1α in unicystic ameloblastoma predicts the efficacy of marsupialization treatment. Medicine (Baltimore) 2018;97:e9795.
  • Referans17. Pogrel MA, Montes DM. Is there a role for enucleation in the management of ameloblastoma? Int J Oral Maxillofac Surg 2009;38:807-12.
  • Referans18. Seintou A, Martinelli-Kläy CP, Lombardi T. Unicystic ameloblastoma in children: systematic review of clinicopathological features and treatment outcomes. Int J Oral Maxillofac Surg 2014;43:405-12.
  • Referans19. Scariot R, da Silva RV, da Silva Felix W, Jr., da Costa DJ, Rebellato NL. Conservative treatment of ameloblastoma in child: a case report. Stomatologija 2012;14:33-6.
  • Referans20. Eckardt AM, Kokemüller H, Flemming P, Schultze A. Recurrent ameloblastoma following osseous reconstruction--a review of twenty years. J Craniomaxillofac Surg 2009;37:36-41.
  • Referans21. Khare G, Kumar S. Application of osteomucoperiosteal flap in large unicystic ameloblastoma to promote early bone healing: An alternative to primary bone grafting. Contemp Clin Dent 2011;2:283-6.
  • Referans22. Ogunsalu C, West W, Lewis A, Williams N. Ameloblastoma in Jamaica--predominantly unicystic: analysis of 47 patients over a 16-year period and a case report on re-entry cryosurgery as a new modality of treatment for the prevention of recurrence. West Indian Med J 2011;60:240-6.
  • Referans23. de Paulo LF, Oliveira MT, Rodrigues Á R, Zanetta-Barbosa D. Treatment of an extensive unicystic ameloblastoma in a 7-year-old child: the best approach? Br J Oral Maxillofac Surg 2015;53:292-4.
  • Referans24. Peter J, Emmatty TB, Jose B, Methippara JJ, Sebastian R, Vasu S. Unicystic Ameloblastoma Associated with Primary Mandibular Second Molar: A Case Report. Int J Clin Pediatr Dent Oral Dis 2022;28:2423-31.
  • Referans25. Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, et al. Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res 2014;20:5517-26.
  • Referans26. Kaye FJ, Ivey AM, Drane WE, Mendenhall WM, Allan RW. Clinical and radiographic response with combined BRAFtargeted therapy in stage 4 ameloblastoma. J Natl Cancer Inst 2015;107:378.
  • Referans27. Hirschhorn A, Campino GA, Vered M, Greenberg G, Yacobi R, Yahalom R, et al. Upfront rational therapy in BRAF V600E mutated pediatric ameloblastoma promotes ad integrum mandibular regeneration. J Tissue Eng Regen Med 2021;15:1155-61.
  • Referans28. Hirschhorn A, Grynberg S, Campino GA, Dobriyan A, Patel V, Greenberg G, et al. Histopathologic and Molecular Insights Following the Management of Ameloblastomas via Targeted Therapies - Pathological and Clinical Perspectives. Head Neck Pathol 2024;18:129.
  • Referans29. Sano K, Yoshimura H, Tobita T, Kimura S, Imamura Y. Spontaneous eruption of involved second molar in unicystic ameloblastoma of the mandible after marsupialization followed by enucleation: a case report. J Oral Maxillofac Surg 2013;71:66-71.
  • Referans30. Ozkan A, Erguven SS, Bayar GR, Sencimen M. The impact of COVID-19 pandemic on patient satisfaction and clinical outcomes after treatment of odontogenic cysts with decompression followed by surgery. Stomatologija 2021;23:101-5.

Genç Hastada Mural Alt Tip Unikistik Ameloblastomun Konservatif Tedavisi: Bir Yıllık Takipli Bir Olgu Sunumu

Yıl 2025, Cilt: 14 Sayı: 1, 57 - 64, 27.01.2025
https://doi.org/10.54617/adoklinikbilimler.1532576

Öz

Giriş: Ameloblastoma, genellikle çene kemiğinde oluşan iyi huylu bir tümördür. Unikistik ameloblastoma, ilk olarak 1977'de tanımlanmış ve 4 tipi vardır. Asıl tedavi cerrahidir. Bu vaka raporu, COVID-19 döneminde unikistik ameloblastoma ve gömülü sol mandibular üçüncü molar dişi olan 13 yaşında bir erkek çocuğun cerrahi tedavisini içermektedir.

Vaka raporu: 13 yaşında bir erkek çocuk, yüz asimetrisine neden olan gömülü alt çene üçüncü molarını çevreleyen radyolusent bir lezyonla Hacettepe Üniversitesi Ağız, Diş ve Çene Cerrahisi Anabilim Dalı'na başvurdu. Tedavi, ikinci moların çekilmesi, biyopsi ve marsupializasyonu içeriyordu. 1 yıllık takipte tekrarlama olmadı.

Sonuç: Marsupializasyon, kistik yapıların drenajı için lezyonun kenarlarının ağız boşluğuna veya sinüslere dikilmesiyle sıvı drenajı için açık bir cep oluşturulmasını içeren konservatif bir tedavi yaklaşımıdır ve özellikle genç hastalar için uygundur. Bu yöntem, kemiğin büyüme potansiyelini korurken estetik sonuçları iyileştirir ve hayati yapıların korunmasını sağlar. Bu vakada, COVID-19 pandemisi nedeniyle lokal anestezi altında konservatif tedavi tercih edilmiş ve marsupializasyonun ardından enükleasyon uygulanmıştır. Bu tür yaklaşımlar, klinik gereksinimleri etkin bir şekilde karşılarken, pandemiler gibi zorlu dönemlerde hastaların psikolojik olarak kendilerini idame etmeleri daha kolay olacaktır.

Kaynakça

  • Referans1. Soluk-Tekkesin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition. Turk Patoloji Derg 2022;38:168-84.
  • Referans2. Robinson L, Martinez MG. Unicystic ameloblastoma: a prognostically distinct entity. Cancer 1977;40:2278-85.
  • Referans3. Poonja K, Galinde J, Dave PM. Unicystic Ameloblastoma. Journal of Contemporary Dentistry 2015;5:40-2.
  • Referans4. Philipsen HP, Reichart PA. Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol 1998;34:317-25.
  • Referans5. Garcia NG, Oliveira DT, Rodrigues MT. Unicystic Ameloblastoma with Mural Proliferation Managed by Conservative Treatment. Case Rep Pathol 2016;2016:3089540.
  • Referans6. Ooi A, Feng J, Tan HK, Ong YS. Primary treatment of mandibular ameloblastoma with segmental resection and free fibula reconstruction: achieving satisfactory outcomes with low implant-prosthetic rehabilitation uptake. J Plast Reconstr Aesthet Surg 2014;67:498-505.
  • Referans7. Hammarfjord O, Roslund J, Abrahamsson P, Nilsson P, Thor A, Magnusson M, et al. Surgical treatment of recurring ameloblastoma, are there options? Br J Oral Maxillofac Surg 2013;51:762-6.
  • Referans8. Lau SL, Samman N. Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review. Int J Oral Maxillofac Surg 2006;35:681-90.
  • Referans9. Nowair IM, Eid MK. A modified surgical approach for the treatment of mandibular unicystic ameloblastoma in young patients. J Craniomaxillofac Surg 2020;48:148-55.
  • Referans10. Zheng CY, Cao R, Hong WS, Sheng MC, Hu YJ. Marsupialisation for the treatment of unicystic ameloblastoma of the mandible: a long-term follow up of 116 cases. Br J Oral Maxillofac Surg 2019; 57:655-62
  • Referans11. Caldeira PC, Schuch LF, Tavares TS, Santos-Silva AR, Vargas PA, Pérez-de-Oliveira ME, et al. Impact of the COVID-19 pandemic on public University laboratories of oral and maxillofacial pathology: A Brazilian multicenter study. Oral Dis 2022;28:2423- 31.
  • Referans12. Maffia F, Fontanari M, Vellone V, Cascone P, Mercuri LG. Impact of COVID-19 on maxillofacial surgery practice: a worldwide survey. Int J Oral Maxillofac Surg 2020;49:827-35.
  • Referans13. Zheng C, Cao R, Hong W, Sheng M, Hu Y. Marsupialisation for the treatment of unicystic ameloblastoma of the mandible: a long-term follow up of 116 cases. British Journal of Oral and Maxillofacial Surgery 2019;57:655-62.
  • Referans14. Datarkar A, Rai A, Bhawalkar A, Jain A. Clinical outcome following conservative treatment of 58 mandibular ameloblastoma patients: a retrospective study. Oral Maxillofac Surg 2023;27:601- 8.
  • Referans15. Srikar M, Sangamesh N, Vidya K. Marsupialization for the Management of Unicystic Ameloblastoma-Retrospective Study. Indian Journal of Public Health 2020;11:593.
  • Referans16. Zhang X, Liu L, Yang X, Wang L, Zhang C, Hu Y. Expression of TP53 and IL-1α in unicystic ameloblastoma predicts the efficacy of marsupialization treatment. Medicine (Baltimore) 2018;97:e9795.
  • Referans17. Pogrel MA, Montes DM. Is there a role for enucleation in the management of ameloblastoma? Int J Oral Maxillofac Surg 2009;38:807-12.
  • Referans18. Seintou A, Martinelli-Kläy CP, Lombardi T. Unicystic ameloblastoma in children: systematic review of clinicopathological features and treatment outcomes. Int J Oral Maxillofac Surg 2014;43:405-12.
  • Referans19. Scariot R, da Silva RV, da Silva Felix W, Jr., da Costa DJ, Rebellato NL. Conservative treatment of ameloblastoma in child: a case report. Stomatologija 2012;14:33-6.
  • Referans20. Eckardt AM, Kokemüller H, Flemming P, Schultze A. Recurrent ameloblastoma following osseous reconstruction--a review of twenty years. J Craniomaxillofac Surg 2009;37:36-41.
  • Referans21. Khare G, Kumar S. Application of osteomucoperiosteal flap in large unicystic ameloblastoma to promote early bone healing: An alternative to primary bone grafting. Contemp Clin Dent 2011;2:283-6.
  • Referans22. Ogunsalu C, West W, Lewis A, Williams N. Ameloblastoma in Jamaica--predominantly unicystic: analysis of 47 patients over a 16-year period and a case report on re-entry cryosurgery as a new modality of treatment for the prevention of recurrence. West Indian Med J 2011;60:240-6.
  • Referans23. de Paulo LF, Oliveira MT, Rodrigues Á R, Zanetta-Barbosa D. Treatment of an extensive unicystic ameloblastoma in a 7-year-old child: the best approach? Br J Oral Maxillofac Surg 2015;53:292-4.
  • Referans24. Peter J, Emmatty TB, Jose B, Methippara JJ, Sebastian R, Vasu S. Unicystic Ameloblastoma Associated with Primary Mandibular Second Molar: A Case Report. Int J Clin Pediatr Dent Oral Dis 2022;28:2423-31.
  • Referans25. Brown NA, Rolland D, McHugh JB, Weigelin HC, Zhao L, Lim MS, et al. Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res 2014;20:5517-26.
  • Referans26. Kaye FJ, Ivey AM, Drane WE, Mendenhall WM, Allan RW. Clinical and radiographic response with combined BRAFtargeted therapy in stage 4 ameloblastoma. J Natl Cancer Inst 2015;107:378.
  • Referans27. Hirschhorn A, Campino GA, Vered M, Greenberg G, Yacobi R, Yahalom R, et al. Upfront rational therapy in BRAF V600E mutated pediatric ameloblastoma promotes ad integrum mandibular regeneration. J Tissue Eng Regen Med 2021;15:1155-61.
  • Referans28. Hirschhorn A, Grynberg S, Campino GA, Dobriyan A, Patel V, Greenberg G, et al. Histopathologic and Molecular Insights Following the Management of Ameloblastomas via Targeted Therapies - Pathological and Clinical Perspectives. Head Neck Pathol 2024;18:129.
  • Referans29. Sano K, Yoshimura H, Tobita T, Kimura S, Imamura Y. Spontaneous eruption of involved second molar in unicystic ameloblastoma of the mandible after marsupialization followed by enucleation: a case report. J Oral Maxillofac Surg 2013;71:66-71.
  • Referans30. Ozkan A, Erguven SS, Bayar GR, Sencimen M. The impact of COVID-19 pandemic on patient satisfaction and clinical outcomes after treatment of odontogenic cysts with decompression followed by surgery. Stomatologija 2021;23:101-5.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Ağız ve Çene Cerrahisi
Bölüm Case Report
Yazarlar

Aydın Onur Gerçek 0000-0002-4424-706X

Selen Adiloğlu 0000-0002-5007-9867

Alper Aktaş 0000-0002-1977-4431

Yayımlanma Tarihi 27 Ocak 2025
Gönderilme Tarihi 22 Ağustos 2024
Kabul Tarihi 23 Aralık 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 14 Sayı: 1

Kaynak Göster

Vancouver Gerçek AO, Adiloğlu S, Aktaş A. Conservative Management of Mural Subtype Unicystic Ameloblastoma in Young Patient: A Case Report with One Year of Follow Up. ADO Klinik Bilimler Dergisi. 2025;14(1):57-64.