Abstract
References
- Referans1 Ballard, S.A., Gingell, C.J., Tang, K., Turner, L.A., Prive, M.E., & Naylor, A.M. (1998). Effect of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. Journal of Urology, 159(6), 2164- 2171. https://doi.org/10.1016/S0022-5347(01)63299-3
- Referans2 Batissaco, L., Celeghini, E. C., Pinaffi, F. L., Oliveira, B. M., Andrade,A., Recalde, E. C., & Fernandes, C. (2013). Correlations betweentesticular hemodynamic and sperm characteristics in rams.Brazilian Journal of Veterinary Research and Animal Science, 50(5),384-395. https://doi.org/10.11606/issn.2318-3659.v50i5p384-395
Abstract
The effect of different doses of sildenafil citrate (SC) administrations on arteria (a.) uterine blood flow was investigated in healthy
female rabbits. Twelve healthy non-pregnant New Zealand rabbits were used in the present study. In the first experimental group
(n=6), 5 mg SC thawed in 0.9% NaCl solution was administered orally. Arteria uterina was examined with Pulsed Doppler ultrasonography
at pre and post (60 minutes) SC administration. Heart rate (HR), pulsatility index (PI) and resistance index (RI) values
were recorded from the a. uterina visualized with cervical channels. Similarly, the study was repeated in second experimental
group (n=6) by using 10 mg SC for per animal. In the first experiment, the mean HR, PI and RI values were recorded as (223 ± 7.80
& 239 ± 15.00), (1.60 ± 0.08 & 1.63 ± 0.16) and (0.73 ± 0.02 & 0.73 ± 0.03) before and after SC administration, respectively. In the
second experiment, the mean HR, PI and RI values were observed as (210 ± 15.00 & 223 ± 14.00), (1.46 ± 0.23 & 1.79 ± 0.08) and
(0.68 ± 0.05 & 0.77 ± 0.01) before and after SC administration, respectively.
No significant difference was between pre and post-administration Doppler parameters in both experiments (P>0.05). Consequently,
no enhancing effect on the uterine perfusion was observed in oral 5 and 10 mg SC administrations per rabbit.
Keywords
References
- Referans1 Ballard, S.A., Gingell, C.J., Tang, K., Turner, L.A., Prive, M.E., & Naylor, A.M. (1998). Effect of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. Journal of Urology, 159(6), 2164- 2171. https://doi.org/10.1016/S0022-5347(01)63299-3
- Referans2 Batissaco, L., Celeghini, E. C., Pinaffi, F. L., Oliveira, B. M., Andrade,A., Recalde, E. C., & Fernandes, C. (2013). Correlations betweentesticular hemodynamic and sperm characteristics in rams.Brazilian Journal of Veterinary Research and Animal Science, 50(5),384-395. https://doi.org/10.11606/issn.2318-3659.v50i5p384-395
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Sciences |
| Journal Section | Research Article |
| Authors | |
| Publication Date | June 5, 2020 |
| Submission Date | June 24, 2020 |
| Published in Issue | Year 2020 Volume: 9 Issue: 1 |
