Sideritis L.'nin Fitokimyasal Bileşimi, Biyolojik ve Farmakolojik Aktiviteleri, Bibliyometrik Analizi

Abstract

Sideritis L. cinsi, geleneksel halk tıbbında uzun yıllardır kullanılan ve fitokimyasal açıdan zengin bir bitki grubudur. Flavonoidler, fenolik bileşikler, diterpenoidler ve uçucu yağlar gibi çok sayıda biyoaktif bileşen içermesi nedeniyle son yıllarda farmakolojik açıdan dikkat çekmektedir. Bu çalışmada, Sideritis türlerinin fitokimyasal bileşimi, antioksidan, antimikrobiyal, antiinflamatuvar ve nöroprotektif gibi biyolojik aktiviteleri ile potansiyel terapötik kullanımları kapsamlı bir şekilde ele alınmıştır. Ayrıca 1983–2025 yılları arasında bu alanda yapılmış bilimsel yayınlar bibliyometrik yöntemlerle incelenmiş, yayın sayıları, en aktif ülkeler, yazarlar ve iş birliği ağları analiz edilmiştir. Elde edilen bulgular, Sideritis türlerinin farmakolojik araştırmalarda ön plana çıktığını, özellikle Avrupa ülkelerinde yoğun olarak çalışıldığını ve son on yılda bu alanda belirgin bir artış olduğunu göstermektedir. Bu çalışma, Sideritis cinsi üzerine yapılacak yeni araştırmalara ışık tutmayı ve bilimsel literatürdeki boşlukları belirlemeyi amaçlamaktadır.

Keywords

• Sideritis L
• Fitokimyasal;
• Farmakolojik Aktivite
• Biyolojik Aktivite
• Bibliyometrik

Bibliometric Analysis of Sideritis L. based on Phytochemical Composition, Biological and Pharmacological Activities

Abstract

The genus Sideritis L. is a phytochemically rich group of plants that have been used in traditional folk medicine for many years. It has attracted pharmacological attention in recent years because it contains a large number of bioactive components such as flavonoids, phenolic compounds, diterpenoids and essential oils. In this study, the phytochemical composition, biological activities such as antioxidant, antimicrobial, anti-inflammatory and neuroprotective activities and potential therapeutic uses of Sideritis species were comprehensively reviewed. In addition, scientific publications in this field between 1983 and 2025 were examined by bibliometric methods, and the number of publications, most active countries, authors and collaboration networks were analyzed. The findings show that Sideritis species have come to the forefront in pharmacological research, especially in European countries, and that there has been a significant increase in this field in the last decade. This study aims to shed light on new research on the genus Sideritis and identify gaps in the scientific literature.

Keywords

• Sideritis L.;
• Phytochemical;
• Pharmacological Activity
• Biological Activity
• Bibliometrics

References

1. [1] Selvi, S., Polat, R., Çakilcioğlu, U., Celep, F., Dirmenci, T., Ertuğ, Z.F., An Ethnobotanical Review on Medicinal Plants of the Lamiaceae Family in Turkey, Turkish Journal of Botany, 46(4), 283–332, 2022.
2. [2] World Flora Online (2023, March 18), Lamiaceae, http://www.worldfloraonline.org/search;jsessionid=46C7B2D7A7560D5E9D2EFF1A91F154 5?query=Lamiaceae&limit=24&start=0&facet=taxon.taxonomic_status_s%3AAccepted&sort
3. [3] Özen, İ., Biological Activity Studies on Some Sideritis L. Species,, Msc Thesis, Eskişehir Anadolu University, Eskişehir, Türkiye, 2003.
4. [4] Kaya, A., Lamiaceae Familyasının Tüy Morfolojisi, Journal of Faculty of Pharmacy of Ankara University, 48(3), 34, 2024.
5. [5] Celep, F., Dirmenci, T., Systematic and biogeographic overview of Lamiaceae in Turkey, Natural Volatiles and Essential Oils, 4(4), 14–27, 2017.
6. [6] Yücer, R., Phytochemical and Bioactivity Studies on Two Endemic *Sideritis* Species, PhD Thesis, Bezmialem Vakıf University, İstanbul, Türkiye, 2023.
7. [7] Tekeş, A., Karagöz, S.G., & Gülsoy, S., Farklı Yükseltilerde Dağçayı (Sideritis pisidica Boiss. & Heldr.)’nın Uçucu Bileşenleri. Düzce Üniversitesi Orman Fakültesi Ormancılık Dergisi, 20(2), 15-27, 2024.
8. [8] Bertsouklis, K., Theodorou, P., & Aretaki, P. E., In vitro propagation of the Mount Parnitha endangered species Sideritis raeseri subsp. Attica, Horticulturae, 8(12), 1114, 2022.

9. [9] Mitropoulou, G., Sidira, M., Skitsa, M., Tsochantaridis, I., Pappa, A., Dimtsoudis, C., et al., Assessment of the antimicrobial, antioxidant, and antiproliferative potential of Sideritis raeseri subsp. raeseri essential oil, Foods, 9(7), 860, 2020.
10. [10] Bouloumpasi, E., Koskeridou, A., Irakli, M., Karioti, A., Tsivelika, N., Chatzopoulou, P., Bioactive Compounds of Green Phenolic Extracts Obtained via Microwave-Assisted Extraction of Sideritis Species Grown in Greece, Molecules, 29(23), 5612, 2024.
11. [11] Zengin, G., Uğurlu, A., Baloglu, M.C., Diuzheva, A., Jekő, J., Cziáky, Z., et al., Chemical fingerprints, antioxidant, enzyme inhibitory, and cell assays of three extracts obtained from Sideritis ozturkii Aytaç & Aksoy: An endemic plant from Turkey, Journal of Pharmaceutical and Biomedical Analysis, 171, 118-125, 2019.
12. [12] Zissi, L., Dimaki, V.D., Birba, V.S., Galani, V.C., Magafa, V., Hatziantoniou, S., et al., Natural Deep Eutectic Solvents as Green Alternatives for Extracting Bioactive Compounds from *Sideritis* Taxa with Potential Cosmetic Applications, Antioxidants, 14(1), 68, 2025.
13. [13] EMA. (2025, February 15). Sideritis herba. https://www.ema.europa.eu/en/medicines/herbal/sideritis-herba
14. [14] Abeshi, A., Precone, V., Beccari, T., Dundar, M., Falsini, B., & Bertelli, M., Pharmacologically active fractions of Sideritis spp. and their use in inherited eye diseases, Eurobiotech J, 1, 6-10, 2017.
15. [15] Deveci, E., Tel-Cayan, G., Duru, M.E., Ozturk, M., Phytochemical contents, antioxidant effectts, and inhibitory activities of key enzymes associated with Alzheimer's disease, ulcer, and skin disorders of Sideritis albiflora and Sideritis leptoclada, Journal of Food Biochemistry, 43(12), e13078, 2019.
16. [16] Kırmızıbekmez, H., Erdoğan, M., Kúsz, N., Karaca, N., Erdem, U., Demirci, F., et al., Secondary metabolites from the aerial parts of Sideritis germanicopolitana and their in vitro enzyme inhibitory activities, Natural Product Research, 35(4), 655-658, 2021.
17. [17] Šavikin, K., Živković, J., Janković, T., Ćujić-Nikolić, N., Zdunić, G., Menković, N., et al., Optimization of ultrasound-assisted extraction of phenolics from Sideritis raeseri using response surface methodology, Molecules, 26(13), 3949, 2021.
18. [18] Dimaki, V. D., Zeliou, K., Nakka, F., Stavreli, M., Bakratsas, I., Papaioannou, L., et al., Characterization of Sideritis clandestina subsp. peloponnesiaca polar glycosides and phytochemical comparison to other mountain tea populations, Molecules, 27(21), 7613, 2022.
19. [19] Chrysargyris, A., Tomou, E. M., Goula, K., Dimakopoulou, K., Tzortzakis, N., Skaltsa, H., et al., Essential oils: A systematic review, Phytochemistry, 209, 113607, 2023.
20. [20] Walasek-Janusz, M., Papliński, R., Mysiak, B., & Nurzyńska-Wierdak, R., Phenolic Profile and Antioxidant Activity of Extracts from Aerial Parts of Thymus vulgaris L. and Sideritis scardica Griseb, Applied Sciences, 15(7), 3842, 2025.
21. [21] Hazrati, S., Beidaghi, P., Beyraghdar Kashkooli, A., Hosseini, S.J., Nicola, S., Effect of harvesting time variations on essential oil yield and composition of Sage (Salvia officinalis), Horticulturae, 8(2), 149, 2022.
22. [22] Altun, M., Phytochemical Components, Antioxidant, Antibacterial, and Synergistic Effects of Endemic Sideritis trojana Extract in Combination with Antibiotics on Human Pathogens, Sakarya University Journal of Science, 27(5), 1008-1018, 2023.
23. [23] Eruygur, N., Kırcı, D., Ayaz, F., Bağcı, Y., Doğu, S., & Yılmaz, M.A., Biological activities and phytochemical investigation of some Sideritis species, Indian Journal of Traditional Knowledge (IJTK), 23(10), 988-998, 2024.
24. [24] Papastavropoulou, K., Oz, E., Oz, F., Proestos, C., Polyphenols from Plants: Phytochemical Characterization, Antioxidant Capacity, and Antimicrobial Activity of Some Plants from Different Sites of Greece, Separations, 9(8), 186, 2022.
25. [25] Tadić, V., Oliva, A., Božović, M., Cipolla, A., De Angelis, M., Vullo, et al., Chemical and antimicrobial analyses of Sideritis romana L. subsp. purpurea (Tal. ex Benth.) Heywood, an endemic of the Western Balkan, Molecules, 22(9), 1395, 2017.
26. [26] Bayan, Y., Aksit, H., Antifungal activity of essential oils and plant extracts from Sideritis germanicopolitana BORNM. growing in Turkey, 2016.
27. [27] Eleftheriou, P., Therianou, E., Lazari, D., Dirnali, S., Micha, A., Docking assisted prediction and biological evaluation of Sideritis L. components with PTP1b inhibitory action and probable anti-diabetic properties, Current Topics in Medicinal Chemistry, 19(5), 383–392, 2019.
28. [28] Cavalcanti, M.R., Passos, F.R., Monteiro, B.S., Gandhi, S.R., Heimfarth, L., Lima, B.S., et al., HPLC-DAD-UV analysis, anti-inflammatory and anti-neuropathic effects of methanolic extract of Sideritis bilgeriana (Lamiaceae) by NF-κB, TNF-α, IL-1β and IL-6 involvement, Journal of Ethnopharmacology, 265, 113338, 2021.
29. [29] Cocelli, G., Pehlivan, M., Yumrutas, O., Sideritis perfoliata inhibits cell proliferation, induces apoptosis and exhibits cellular antioxidant activity in cervical cancer cells, BLACPMA, 20(4), 394-405, 2021.
30. [30] Yücer, R., Schröder, A., Topçu, G., Efferth, T., Identification of Anti-Inflammatory and Anti-Cancer Compounds Targeting the NF-κB-NLRP3 Inflammasome Pathway from a Phytochemical Library of the *Sideritis* Genus, Journal of Ethnopharmacology, 338, 119074, 2025.
31. [31] Turkmenoglu, F.P., Baysal, İ., Ciftci-Yabanoglu, S., Yelekci, K., Temel, H., Paşa, S., et al., Flavonoids from Sideritis species: human monoamine oxidase (hMAO) inhibitory activities, molecular docking studies and crystal structure of xanthomicrol, Molecules, 20(5), 7454-7473, 2015.
32. [32] Saral, Ö., Baltaş, N., Karaköse, M., An Inhibition Potential on Some Metabolic Enzymes (Urease and Xanthine Oxidase), Essential Oil Contents and Antioxidant Effect of *Sideritis lanata* L., Chemical Papers, 78(15), 8211–8217, 2024.
33. [33] Web of Science (WOS) Database (2025, April 20) https://www.webofscience.com/wos/woscc/basic-search
34. [34] Öztürk Sarıkaya, S. B., & Zehiroğlu, C., Endemic Mountain Tea (Sideritis dichotoma Huter): Antioxidant and Antibacterial Activities, Mineral Content by ICP‐MS and Phytochemical Content by LCHR‐MS, Chemistry & Biodiversity, 20(12), e202301453, 2023.
35. [35] Aria, M., Cuccurullo, C., Bibliometrix: An R-tool for comprehensive science mapping analysis, Journal of Informetrics, 11, 959–975, 2017.
36. [36] Massimo, A.; Corrado, C., Bilionshiny bibliometrix. 2020. https://www.bibliometrix.org/biblioshiny/
37. [37] Van Eck, N., Waltman, L., Software Survey: VOSviewer, a Computer Program for Bibliometric Mapping, Scientometrics, 84(2), 523–538, 2010.
38. [38] González-Burgos, E., Carretero, M. E., Gómez-Serranillos, M. P., Sideritis spp.: Uses, chemical composition and pharmacological activities—A review, Journal of Ethnopharmacology, 135(2), 209–225, 2011.
39. [39] Ministry of Agriculture and Forestry. (2025, May 5). Plant Protection Research. https://arastirma.tarimorman.gov.tr/etae/Sayfalar/Detay.aspx?SayfaId=65.