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COVID-19 Tanısı ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz

Year 2024, Volume: 8 Issue: 3, 284 - 288, 17.12.2024
https://doi.org/10.46332/aemj.1230472

Abstract

Amaç: Çalışmada, bir üniversite hastanesinin yoğun bakım ünitesinde takip edilmiş olan COVID-19 hastalarının bazı sosyo-demografik ve laboratuvar verilerini değerlendirmek amaçlanmıştır.

Araçlar ve Yöntem: Retrospektif tek merkezli çalışmada, 11 Mart -31 Mayıs 2020 tarihleri arasında bir Üniversite Hastanesi’ndeki COVID-19 yoğun bakım ünitelerinde laboratuvar onaylı COVID-19'lu 105 hastanın kayıtları incelenmiştir.

Bulgular: Çalışmada hastaların yaş ortalaması 68.83±13.04’tür. Hastaların %40.0’ı kadın, %60.0’ı ise erkektir. Yoğun bakımda yatan hastaların %59.0’ı taburcu olurken %41.0’ı vefat etmiştir. Hastaların %45.7’sinin hemoglobin, %13.3’ünün trombosit, %72.4 lenfosit değerlerinin normalin altında olduğu belirlenmiştir. Hastaların %45.7’sinin lökosit, %68.6’sının nötrofil, %69.5’inin glikoz, %56.2’sinin üre, %60.0’ının kreatin, %30.5’inin aspartat aminotransferaz, %15.2’sinin alanin aminotransferaz, %62.9’unun C-reaktif protein, %25.7’sinin alkalen fosfataz, %54.3’ünün troponini, %15.2’sinin CK-MB, %37.1’inin ferritin, %48.6’ısının D-Dimer ve %60.0’ının fibrinojen düzeyinin artmış olduğu belirlenmiştir.

Sonuç: Araştırma bulguları tek bir hastanenin sonuçlarını yansıtmaktadır. Çalışmada yoğun bakımda yatan hastaların neredeyse tamamına yakını yaşlı olup %41.0’ı vefat etmiştir. Çalışmaya alınan hastaların yarıdan fazlasında lenfopeni ve nötrofili oluştuğu belirlenmiştir.

References

  • 1. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novelcorona virüs pneumonia in Wuhan, China: a descriptivestudy. The Lancet. 2020;395(10223):507-513.
  • 2. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv. 2020;382:1708-1720.
  • 3. Hui DS, I Azhar E, Madani TA, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264-266.
  • 4. Ransing R, Adiukwu F, Pereira-Sanchez V, et al. Mental health ınterventions during the COVID-19 Pandemic: a conceptual framework by early career psychiatrists. Asian J Psychiatr. 2020;51(102085):1-8.
  • 5. Tabata S, Imai K, Kawano S, et al. Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis. Lancet Infect Dis. 2020;20(9):1043-1050.
  • 6. World Health Organizasiton. Naming the coronavirus disease (COVID-19) and the virus that causes it. 2020. https://www.who. int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-thecoronavirus-disease-(covid-2019)-and-the-virusthat-causes-it. Erişim tarihi 3 Aralık, 2021.
  • 7. Zhang R, Li M, Zhao K. Retrospective Analysis of COVID-19 Outbreak Caused by Administrative Actions of Wuhan Authorities: Mistakes Should Be Avoided in Other Country.2020;1:3555261.
  • 8. COVID-19 (SARS-CoV-2 Enfeksiyonu) (Bilim Kurulu Çalışması) Genel Bilgiler Epidemiyoloji ve Tanı. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü. 12 Nisan 2020, Ankara. https://covid19bilgi.saglik.gov.tr/depo/rehberler/covid-19-rehberi/Covıd-19_Rehberı_Genel_Bılgıler_Epıdemıyolojı_Ve_Tanı.pdf Erişim tarihi 15 Mart, 2021.
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  • 10. T.C. Sağlık Bakanlığı COVID-19 Bilgilendirme Platformu. 2021. Available from: https://covid19.saglik.gov.tr/ Erişim tarihi 13 Mart, 2021.
  • 11. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497-506.
  • 12. Phua J, Weng L, Ling L, et al. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med. 2020;8(5):506-517.
  • 13. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. Jama. 2020;323(11):1061-1069.
  • 14. Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91-95.
  • 15. Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China. Allergy. 2020;75(7):1730-1741.
  • 16. Özdemir A, Erdivanlı B, Özdemir A, et al. Adjuvan tedavilerin COVID-19 pozitif yoğun bakım hastaların morbidite ve mortalitelerine etkisi. Turk J Intensive Care. 2020;18(1):31-38.
  • 17. İşsever, K., Çekiç, D., Etçioğlu, E., Genç, A. C., Genç, A. B., Yaylacı, S. COVID-19 Tanısıyla Hastaneye Yatan Hastaların Genel Karakteristik Özellikleri ve Başvuru Semptomları ile Klinik Seyirleri Arasındaki İlişki: Tek Merkez Deneyimi. OTSBD. 2022;7(4):511-516.
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  • 20. Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020;20(6):669-667.
  • 21. Kubat Bakır G, Akın S. Yaşlılıkta kronik hastalıkların yönetimi ile ilişkili faktörler. Sağlık ve Toplum. 2019;29(2):17-25.
  • 22. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924.
  • 23. Lian J, Jin X, Hao S, et al. Analysis of epidemiological and clinical features in older patients with coronavirus disease 2019 (COVID-19) Outside Wuhan. Clin Infect Dis. 2020;71(15):740-747.
  • 24. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-1062.
  • 25. Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients ınfected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-1581.
  • 26. Altın Z. COVID-19 pandemisinde yaşlılar. Tepecik Eğit. ve Araşt. Hast. Dergisi 2020;30(Ek sayı):49-57.
  • 27. Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. J Heart Lung Transplant. 2020;39(5):405-407.
  • 28. Tan L, Wang Q, Zhang D, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Curr. Signal Transduct. Ther. 2020;5(1):33.
  • 29. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;395(10223):473-475.
  • 30. Ding Q, Lu P, Fan Y, Xia Y, Liu M. The clinical characteristics of pneumonia patients co-infected with 2019 novel coronavirus and influenza virus in Wuhan, China. J Med Virol. 2020;92(9):1549-1555.

Characteristics of Patients in Intensive Care Units with the Diagnosis of COVID-19: Retrospective Analysis

Year 2024, Volume: 8 Issue: 3, 284 - 288, 17.12.2024
https://doi.org/10.46332/aemj.1230472

Abstract

Purpose: The aim of the study was to evaluate some socio-demographic and laboratory data of COVID-19 patients who were followed up in the intensive care unit of a university hospital.

Materials and Methods: In this retrospective, single-center study, the records of 105 laboratory-confirmed COVID-19 patients in the intensive care units of a University Hospital were reviewed between March 11 and May 31, 2020.

Results: The mean age of the patients in the study was 68.83±13.04 years. 40.0% of the patients were female and 60.0% were male. While 59.0% of the patients hospitalised in intensive care unit were discharged, 41.0% of them died. It was determined that 45.7% of the patients had hemoglobin levels, 13.3% had platelet counts, and 72.4% had lymphocyte values below normal. It was determined that 45.7% of the patients had elevated leukocyte levels, 68.6% had elevated neutrophil levels, 69.5% had elevated glucose levels, 56.2% had elevated urea levels, 60.0% had elevated creatinine levels, 30.5% had elevated aspartate aminotransferase levels, 15.2% had elevated alanine aminotransferase levels, 62.9% had elevated C-reactive protein levels, 25.7% had elevated alkaline phosphatase levels, 54.3% had elevated troponin levels, 15.2% had elevated CK-MB levels, 37.1% had elevated ferritin levels, 48.6% had elevated D-Dimer levels, and 60.0% had elevated fibrinogen levels.

Conclusion: The research findings reflect the results of a single hospital. In the study, almost all of the patients in the intensive care unit were elderly, and 41.0% of them died. It was determined that more than half of the patients included in the study developed lymphopenia and neutrophilia.

References

  • 1. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novelcorona virüs pneumonia in Wuhan, China: a descriptivestudy. The Lancet. 2020;395(10223):507-513.
  • 2. Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China. MedRxiv. 2020;382:1708-1720.
  • 3. Hui DS, I Azhar E, Madani TA, et al. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264-266.
  • 4. Ransing R, Adiukwu F, Pereira-Sanchez V, et al. Mental health ınterventions during the COVID-19 Pandemic: a conceptual framework by early career psychiatrists. Asian J Psychiatr. 2020;51(102085):1-8.
  • 5. Tabata S, Imai K, Kawano S, et al. Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis. Lancet Infect Dis. 2020;20(9):1043-1050.
  • 6. World Health Organizasiton. Naming the coronavirus disease (COVID-19) and the virus that causes it. 2020. https://www.who. int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-thecoronavirus-disease-(covid-2019)-and-the-virusthat-causes-it. Erişim tarihi 3 Aralık, 2021.
  • 7. Zhang R, Li M, Zhao K. Retrospective Analysis of COVID-19 Outbreak Caused by Administrative Actions of Wuhan Authorities: Mistakes Should Be Avoided in Other Country.2020;1:3555261.
  • 8. COVID-19 (SARS-CoV-2 Enfeksiyonu) (Bilim Kurulu Çalışması) Genel Bilgiler Epidemiyoloji ve Tanı. T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü. 12 Nisan 2020, Ankara. https://covid19bilgi.saglik.gov.tr/depo/rehberler/covid-19-rehberi/Covıd-19_Rehberı_Genel_Bılgıler_Epıdemıyolojı_Ve_Tanı.pdf Erişim tarihi 15 Mart, 2021.
  • 9. World Health Organizasiton. Coronavirus (COVID-19) Dashboard 2021. Available from: https://covid19.who.int/ Erişim tarihi 13 Mart, 2021.
  • 10. T.C. Sağlık Bakanlığı COVID-19 Bilgilendirme Platformu. 2021. Available from: https://covid19.saglik.gov.tr/ Erişim tarihi 13 Mart, 2021.
  • 11. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497-506.
  • 12. Phua J, Weng L, Ling L, et al. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med. 2020;8(5):506-517.
  • 13. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. Jama. 2020;323(11):1061-1069.
  • 14. Yang J, Zheng Y, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91-95.
  • 15. Zhang JJ, Dong X, Cao YY, et al. Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China. Allergy. 2020;75(7):1730-1741.
  • 16. Özdemir A, Erdivanlı B, Özdemir A, et al. Adjuvan tedavilerin COVID-19 pozitif yoğun bakım hastaların morbidite ve mortalitelerine etkisi. Turk J Intensive Care. 2020;18(1):31-38.
  • 17. İşsever, K., Çekiç, D., Etçioğlu, E., Genç, A. C., Genç, A. B., Yaylacı, S. COVID-19 Tanısıyla Hastaneye Yatan Hastaların Genel Karakteristik Özellikleri ve Başvuru Semptomları ile Klinik Seyirleri Arasındaki İlişki: Tek Merkez Deneyimi. OTSBD. 2022;7(4):511-516.
  • 18. Epidemiology for public health Istituto Superiore di Sanità. Characteristics of COVID-19 patients dying in Italy Report based on available data on 1st March, 2021. https://www.epicentro.iss.it/en/coronavirus/bollettino/Report-COVID 2019_1_march_2021.pdf. Erişim tarihi 1 Mart, 2021.
  • 19. Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relationto COVID-19 in Italy. JAMA. 2020;323(18):1775-1776.
  • 20. Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020;20(6):669-667.
  • 21. Kubat Bakır G, Akın S. Yaşlılıkta kronik hastalıkların yönetimi ile ilişkili faktörler. Sağlık ve Toplum. 2019;29(2):17-25.
  • 22. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924.
  • 23. Lian J, Jin X, Hao S, et al. Analysis of epidemiological and clinical features in older patients with coronavirus disease 2019 (COVID-19) Outside Wuhan. Clin Infect Dis. 2020;71(15):740-747.
  • 24. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-1062.
  • 25. Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients ınfected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574-1581.
  • 26. Altın Z. COVID-19 pandemisinde yaşlılar. Tepecik Eğit. ve Araşt. Hast. Dergisi 2020;30(Ek sayı):49-57.
  • 27. Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. J Heart Lung Transplant. 2020;39(5):405-407.
  • 28. Tan L, Wang Q, Zhang D, et al. Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Curr. Signal Transduct. Ther. 2020;5(1):33.
  • 29. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;395(10223):473-475.
  • 30. Ding Q, Lu P, Fan Y, Xia Y, Liu M. The clinical characteristics of pneumonia patients co-infected with 2019 novel coronavirus and influenza virus in Wuhan, China. J Med Virol. 2020;92(9):1549-1555.
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Original Articles
Authors

Zeynel Abidin Erbesler 0000-0002-1571-1695

Gökçe Demir 0000-0003-3674-9980

Yeşim Zülkar 0000-0003-2226-8799

Early Pub Date December 11, 2024
Publication Date December 17, 2024
Published in Issue Year 2024 Volume: 8 Issue: 3

Cite

APA Erbesler, Z. A., Demir, G., & Zülkar, Y. (2024). COVID-19 Tanısı ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz. Ahi Evran Medical Journal, 8(3), 284-288. https://doi.org/10.46332/aemj.1230472
AMA Erbesler ZA, Demir G, Zülkar Y. COVID-19 Tanısı ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz. Ahi Evran Med J. December 2024;8(3):284-288. doi:10.46332/aemj.1230472
Chicago Erbesler, Zeynel Abidin, Gökçe Demir, and Yeşim Zülkar. “COVID-19 Tanısı Ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz”. Ahi Evran Medical Journal 8, no. 3 (December 2024): 284-88. https://doi.org/10.46332/aemj.1230472.
EndNote Erbesler ZA, Demir G, Zülkar Y (December 1, 2024) COVID-19 Tanısı ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz. Ahi Evran Medical Journal 8 3 284–288.
IEEE Z. A. Erbesler, G. Demir, and Y. Zülkar, “COVID-19 Tanısı ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz”, Ahi Evran Med J, vol. 8, no. 3, pp. 284–288, 2024, doi: 10.46332/aemj.1230472.
ISNAD Erbesler, Zeynel Abidin et al. “COVID-19 Tanısı Ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz”. Ahi Evran Medical Journal 8/3 (December 2024), 284-288. https://doi.org/10.46332/aemj.1230472.
JAMA Erbesler ZA, Demir G, Zülkar Y. COVID-19 Tanısı ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz. Ahi Evran Med J. 2024;8:284–288.
MLA Erbesler, Zeynel Abidin et al. “COVID-19 Tanısı Ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz”. Ahi Evran Medical Journal, vol. 8, no. 3, 2024, pp. 284-8, doi:10.46332/aemj.1230472.
Vancouver Erbesler ZA, Demir G, Zülkar Y. COVID-19 Tanısı ile Yoğun Bakım Ünitelerinde Yatan Hastaların Özellikleri: Retrospektif Analiz. Ahi Evran Med J. 2024;8(3):284-8.

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