Helicobacter pylori eradikasyon tedavisinin tam kan sayımı ve inflamatuvar parametrelere etkisi

Öz

Giriş ve amaç: Helicobacter pylori (H. pylori) enfeksiyonun inflamatuvar ve tam kan sayımı parametrelerinde değişikliklere neden olduğu daha önce bildirilmiştir. Ancak eradikasyon tedavisi sonrasında bu parametrelerdeki değişiklikler yeterince incelenmemişti. Bu çalışmanın amacı eradikasyonunun, inflamatuar belirteçler ve tam kan sayımı parametreleri üzerine etkisinini belirlemektir. Gereç ve yöntem: Bu tek merkezli gözlemsel çalışma Temmuz 2021 ile Ocak 2022 tarihleri arasında iç hastalıkları polikliniğine dispeptik yakınmaları nedeniyle başvuran ve üst gis endoskopisi uygulanan hastalardan Helicobacter pylori testi pozitif saptananlarla yapıldı. Tedaviden 8 hafta sonra yapılan kontrolde eradikasyonu başarılı olan hastalar çalışmaya alındı. Tedavi öncesi ve tedavi sonrası laboratuvar parametreleri kıyaslandı. Bulgular: Hastaların ortalama yaşı 43.84±12.59 idi. Tedavi sonrası C- reaktif protein (CRP), trombosit lenfosit oranı (PLR) ve nötrofil lenfosit oranı (NLR) değerinde anlamlı azalma olduğu saptandı. Trombosit sayısı ve ortalama trombosit hacmi (MPV) değerleri tedavi öncesi ve sonrasında farklılık bulunmadı. Sonuç: Helicobacter pylori eradikasyonu yapılan hastalarda CRP, PLR ve NLR gibi inflamatuar belirteçler tedavi öncesine göre anlamlı olarak azalmaktadır. Bunlar Helicobacter pylori enfeksiyonunun değerlendirilmesinde kullanılabilecek, ucuz invaziv olmayan paramatreler olabilir.

Anahtar Kelimeler

• Helicobacter pylori
• trombosit sayısı
• C-reaktif protein
• tam kan sayımı

Effect of eradication treatment for Helicobacter pylori on complete blood count and inflammatory parameters

Öz

Background and aims: Previously Helicobacter pylori (H. Pylori) infection was held responsible for changes in complete blood count and inflammatory parameters. But changes in these parameters after eradication treatment was not entirely evaluated. This study was designed to evaluate the effect of eradication threatment for H. pylori infection on inflammatory markers and complete blood count parameters. Materials and method: This single center observational study enrolled participants who came to internal medicine outpatient clinics because of dyspeptic complaints and who were diagnosed to have H. pylori infection after endoscopic evaluation, between July 2021 and January 2022. Participants who were tested negative for H. pylori stool antigen test eight weeks after eradication treatment were included. Complete blood count and infammatory parameters before and after eradication treatment were compared. Results: Mean participant age was 43.84±12.59 years. There were significant decreases in C-reactive protein (CRP), platelet to lymphocyte ratio (PLR) and neutrophile to lymphocyte ratio (NLR) after eradication. Changes in platelet counts and mean platelet volumes (MPV) were insignificant. Conclusion: CRP, PLR and NLR were significantly lower after eradication for H. pylori. These parameters may be useful, simple, available and non-invasive tests that may be used in evaluation of eradication treatment for H. pylori.

Anahtar Kelimeler

• Helicobacter pylori
• platelet count
• c-reactive protein
• blood cell count

Kaynakça

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