Retinopathy associated with interferon: Case report

Öz

nterferon therapy has been known to produce various responses, such as creating an antiviral effect, inhibiting cell proliferation, and modulating immunity. It has been used to treat various systemic disorders, including neoplastic disease and chronic hepatitis. The agent is also known to inhibit vascular endothelial cells and angiogenesis. Various adverse effects of interferon therapy have been reported. Interferon is also known to cause ocular toxicity such as retinopathy and subconjunctival hemorrhages. Thirty patients with chronic hepatitis C between 21 and 52 years of age (female 16, male 14; mean age 40.6) were treated with interferon 2 alpha and ribavirin. Seventeen patients experienced different side effects, and one patient developed ocular toxicity. We dropped out because of ocular side effects but ocular finding were lasted.

Anahtar Kelimeler

• Interferon,hepatitis C,retinopathy

İnterferon kullanımı ile ilişkili retinopati: Olgu sunumu

Öz

İnterferon tedavisi antiviral etkisi yanında, hücre proliferasyonunu baskılamak, immün sistemi düzenlemek gibi değişik nedenlerle kulanılmaktadır. BU ilaçların neoplastik hastalıklar, kronik viral hepatit tedavisi yanında vasküler endotelyal hücre proliferasyonu ve anjiogenezi baskılama gibi etkileri de vardır. İnterferon tedavisinin değişik yan etkileri bulunmaktadır. Retinopati, konjunktiva altı kanamaları gibi oküler toksisiteleri de bilinir. Biz burada; kronik hepatit C tanısı alan ve interferon +ribavirin tedavisi sonrası retinopati gelişen bir vakayı sunacağız. Hastanın oküler yan etkilerden dolayı interfeon tedavisinin kesilmesine rağmen oküler bulgular uzun süre sebat etmiştir.

Anahtar Kelimeler

• İnterferon,hepatit C

Kaynakça

1. 1-Quesada JR, Talpaz M, Rios A, et al. Clinical toxicity of interferons in cancer patients. A review. J Clin Oncol 1986;4:234-43. 2-Baron S, Tyring SK, Fleischmann VR, et al. The interferons: mechanism of action and clinical applications. JAMA 1991;266:1375-83. 3-Kawano T, Shigehiro M, Uto H, et al. Retinal complications during interferon therapy for chronic hepatitis C. Am J Gastroenterol 1996;91:309-13. 4-Ikebe T, Nakatsuka K, Gono M, et al. A case of retinopathy induced by intraveneous administration of interferon. Folia Opthalmol Jpn 1990;41:2291-6. 5-Köse Ş, Türken M, Kuzucu L, ve ark. Kronik hepatit B ve hepatit C hastalarında pegile interferon alfa tedavisi öncesi ve sonrası göz bulguları. Viral Hepatoloji Dergisi 2014;20:10-5. 6-Kashif M, Saleem MK, Farooka IK, et al. Incidence of retinopathy in chronic hepatitis C patients treated with pegylated interferon alpha 2a and ribavirin combination theraphy. Pak J Med Sci 2015;31:174-7. 7-Tsoumani A, Theopistos V, Katsanos K, et al. Treatment and non-treatment related ocular manifestations in patients with chronic hepatitis B or C. Eur Rev Med Pharmacol Sci 2013;17:1123-31. 8-O'Day R, Gillies MC, Ahlenstiel G. Ophthalmologic complications of antiviral therapy in hepatitis C treatment. World J Gastroenterol 2013;19:8227-37. 9-Hayasaka S, Nagaki Y, Matsumoto M, Sato S. Interferon associated retinopathy. Br J Opthalmol 1998;82:323-5. 10-Jain K, Lam WC, Waheeb S, et al. Retinopathy in chronic hepatitis C patients during interferon treatment with ribavirin. Br J Ophthalmol 2001;85:1171-3. 11-Guyer DR, Thiedeman J, Yannuzzi LA, et al. Interferon-Associated Retinopathy. Arch Opthalmol 1993;111:350-6. 12-Chambers RB, Downie A, Foote B, Davidorf FH. Interferon alfa-associated retinopathy. J Am Osteopath Assoc 1997;97:43-5. 13-Sugano S, Tokuya S, Watanabe M, et al. Retinal complications and plasma C5a levels during interferon alpha theraphy for chronic hepatitis C. Am J Gastroenterol 1998;93:2441-4. 14-Tokai R, Ikeda T, Miyaura T, Sato K. Interferon-associated retinopathy and cystoid macular edema. Arch Opthalmol 2001;119:1077-9. 15-Nishiwaki H, Ogura Y, Miyamoto K, et al. Interferon alfa induces leukocyte capillary trapping in rat retinal microcirculation. Arch Opthalmol 1996;114:726-30. 16-Nadir A, Amin A, Chalisa N, van Thiel DH. Retinal vein thrombosis associated with chronic hepatitis C. a case series and review of the literature. J Viral Hepat 2000;7:466-70. 17-Nishiguchi S, Shiomu S, Enomoto M, et al. Does ascorbic acid prevent retinopathy during interferon theraphy in patients with chronic hepatitis C? J Gastroenterol 2001;36:486-91.