Konya il merkezinde gastroözofageal reflü hastalığı prevalansı

Öz

Giriş ve Amaç: Gastroözofageal reflü hastalığı üst gastrointestinal kanalın sık rastlanılan bir hastalığıdır. Anatomik lokalizasyonu nedeniyle özofagusa komşuluğu olan organların hastalıklarını taklit edebildiği gibi; asıl hastalığın şikayetini maskeleyebilmekte hatta oluşan komplikasyonları da başka organların fonksiyonlarını bozabilmektedir. Dünyada batı tipi yaşantısı olan toplumlarda daha sık görülmektedir. Türkiye’de hastalık epidemiyolojisi ile sınırlı veri vardır. Gereç ve Yöntem: Yaşadığımız çevrenin prevalansını belirleyebilmek amaçlı yapılan çalışmada Konya İli Merkez İlçelerinde önceden belirlenmiş rastgele adreslerdeki 2000 kişi ile anket görüşmesi yapılmıştır. Bulgular: 1188 kişi ile anket tamamlanabilmiş, (%59 geri dönüş oranı), katılımcıların 581’i kadın (%48.9), 607’si erkek (%51.1), yaş ortalaması 41.34±12.8 olarak hesaplanmıştır. Aylık semptomlar göz önüne alındığında aylık %10,9 prevalans bulunmuştur. Cinsiyet, medeni hal, eğitim düzeyi, meslek ve gelir durumu reflü ile ilişkili bulunmazken yaş ve vücut kitle indeksi ile korelasyon saptanmıştır (p<0.05). Sonuç: Bulunan sonuç itibariyle Konya İli merkez ilçelerinde her üç kişiden birinin kilolu ya da obez olduğu saptanmış, reflü prevalansının batı ülkelerine yakın olduğu görülmüştür.

Anahtar Kelimeler

• Gastroözofageal reflü,prevalans,Konya

Prevalence of gastroesophageal reflux in the central province of Konya

Öz

Background and Aims: Gastroesophageal reflux is a common disease of the upper gastrointestinal tract. Because of the localization of esophagus, gastroesophageal reflux can mimic the disease symptoms of other organs and mask the symptoms of the main illness. Furthermore, some of its complications can impair the functions of other organs. Reflux is common in the Western-societies; however, in Turkey, there is limited data related to the epidemiology of this disease. Therefore, this study aimed to determine the prevalence of gastrointestinal reflux in Turkey. Materials and Methods: In this study, 2000 individuals were randomly interviewed in the predetermined addresses of the central districts of Konya. Results: The questionnaire was completed by 1188 subjects (response rate, 59%), including 581 (48.9%) women and 607 (51.1%) men. The mean age of participants was 41.34±12.8 years. Gastroesophageal symptoms were prevalent in 10.9% of the study population. There were no significant associations between gastroesophageal reflux disease and sex, marital status, level of education, profession, or level of income. However, age and body mass index had a significant positive correlation with gastroesophageal reflux disease (p < 0.05). Conclusion: This study demonstrated that one of every three subjects in the central region of Konya was overweight or obese and the prevalence of gastroesophageal reflux was similar to that in the Western countries.

Anahtar Kelimeler

• Gastroesophageal reflux,prevalence,Konya

Kaynakça

1. KAYNAKLAR
2. 1. El-Serag HB, Sweet S, Winchester CC, Dent J. Update on the epidemiyology of gastrooesophageal reflux disease: a systematic review. Gut 2014;63:871-80.
3. 2. DeVault KR, Castell DO; American College of Gastroenterology. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 2005;100:190‐200.
4. 3. Vakil N, van Zanten SV, Kahrilas P, et al; Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence‐based consensus. Am J Gastroenterol 2006;101:1900‐20.
5. 4. Camilleri M, Dubois D, Coulie B, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol. 2005;3:543‐52.
6. 5. Zagari RM, Fuccio L, Wallander MA, et al. Gastrooesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano‐Monghidoro study. Gut 2008;57:1354‐9.
7. 6. A Gallup Organization National Survey: Heartburn across America. Princeton, NJ, The Gallup Organization, 1988 from uptodate 18.3.
8. 7. Stanghellini V. Three‐month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol Suppl. 1999;231:20‐8.

9. 8. Ho KY, Kang JY, Seow A. Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux‐type symptoms. Am J Gastroenterol 1998;93:1816‐22.
10. 9. Fujiwara Y, Takahashi S, Arakawa T, et al; IGICS Study Group. A 2008 questionnaire‐based survey of gastroesophageal reflux disease and related diseases by physicians in East Asian countries. Digestion 2009;80:119‐28.
11. 10. Spechler SJ. Epidemiology and natural history of gastro‐oesophageal reflux disease. Digestion 1992;51(Suppl 1):24‐9.
12. 11. Bor S, Mandiacioglu A, Kitapcioglu G, et al. Gastroesophageal reflux disease in a low-income region in Turkey. Am J Gastroenterol 2005;100:759-65.
13. 12.Yonem O, Sivri B, Ozdemir L, et al. Gastroesophageal reflux disease prevalance in the city of Sivas. Turk J Gastroenterol 2013;24:303-10.
14. 13. Mungan Z. Prevalance and demographic determinants of gastroesophageal reflux disease (GERD) in the Turkish general population-based cross-sectional study. Turk J Gastroenterol 2012;23:323-32.
15. 14. Ergül R, Dağlı Ü, Özmen E, et al. Bolu İl Merkezi'nde gastroözofageal reflü hastalığı prevalansı: popülasyona dayalı çalışma. Turk J Gastroenterol 2012;23 (Suppl 1):SS-07.
16. 15. Bor S, Vardar R, Vardar E, et al. Endoscopic findings of gastroesophageal reflux disease in Turkey: Multicenter prospectve study (Gorhen). Gastroenterology 2008;134:4(Suppl 1); A-600.
17. 16. Bor S, Yuksel ES. Gastroözofageal reflü hastalığı prevalansı, insidans ve komplikasyonlarının (striktür/özofajit/Barrett/karsinom) sıklığı dünyanın değişik coğrafi bölgeleriyle karşılaştırıldığında nasıldır? Turk J Gastroenterol 2017;28(Suppl 1):S4-9.
18. 17. Fujiwara Y, Higuchi K, Watanabe Y, et al. Prevalence of gastroesophageal reflux disease and gastroesophageal reflux disease symptoms in Japan. J Gastroenterol Hepatol 2005;20:26‐9.
19. 18. Ponce J, Vegazo O, Beltran B, et al; Iberge Study Group. Prevalence of gastrooesophageal reflux disease in Spain and associated factors. Aliment Pharmacol Ther 2006;23:175‐84.
20. 19. Nocon M, Keil T, Willich SN. Prevalence and sociodemographics of reflux symptoms in Germany‐‐results from a national survey. Aliment Pharmacol Ther 2006;23:1601‐5.
21. 20. Bollschweiler E, Knoppe K, Wolfgarten E, Holscher AH. Prevalence of dysphagia in patients with gastroesophageal reflux in Germany. Dysphagia 2008;23:172‐6.
22. 21. Jung HK, Halder S, McNally M, et al. Overlap of gastro‐oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population. Aliment Pharmacol Ther 2007;26:453‐61.
23. 22. Yuen E, Romney M, Toner RW, et al. Prevalence, knowledge and care patterns for gastro‐oesophageal reflux disease in United States minority populations. Aliment Pharmacol Ther 2010;32:645‐54.
24. 23. Chiocca JC, Olmos JA, Salis GB, et al; Argentinean Gastro-Oesophageal reflux study group. Prevalence, clinical spectrum and atypical symptoms of gastro‐oesophageal reflux in Argentina: a nationwide population‐based study. Aliment Pharmacol Ther 2005;22:331‐42.
25. 24. Ronkainen J, Aro P, Storskrubb T, et al. Gastrooesophageal reflux symptoms and health‐related quality of life in the adult general population‐ the Kalixanda study. Aliment Pharmacol Ther 2006;23:1725‐33.
26. 25. Watson DI, Lally CJ. Prevalence of symptoms and use of medication for gastroesophageal reflux in an Australian community. World J Surg 2009;33:88‐94.
27. 26. Mohammed I, Nightingale P, Trudgill NJ. Risk factors for gastro‐oesophageal reflux disease symptoms: a community study. Aliment Pharmacol Ther 2005;21:821‐7.
28. 27. Mostaghni A, Mehrabani D, Khademolhosseini F, et al. Prevalence and risk factors of gastroesophageal reflux disease in Qashqai migrating nomads, southern Iran. World J Gastroenterol 2009;15:961‐5.
29. 28. Türkiye Diyabet, Hipertansiyon, Obezite ve Endokrinolojik Hastalıklar Prevalans Çalışması‐II (TURDEP-II), http://www.turkendokrin.org/files/file/TURDEP_II_2011.pdf
30. 29. Moshkowitz M, Horowitz N, Halpern Z, Santo E. Gastroesophageal reflux disease symptoms: Prevalence, sociodemographics and treatment patterns in the adult Israeli population. World J Gastroenterol 2011;17:1332‐5.
31. 30. Wong BC, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol 2006;4:398‐407.
32. 31. Yamagishi H, Koike T, Ohara S, et al. Prevalence of gastroesophageal reflux symptoms in a large unselected general population in Japan. World J Gastroenterol 2008;14:1358‐64.
33. 32. Cho YS, Choi MG, Jeong JJ, Chung WC, Lee IS, Kim SW, et al. Prevalence and clinical spectrum of gastroesophageal reflux: a population‐based study in Asan‐si, Korea. Am J Gastroenterol 2005;100:747‐53.
34. 33. Oğuz D, Köksal AŞ, Özden A. Türkiye' de birinci basamak sağlık kuruluşlarına başvuran hastalarda gastroözofageal reflü hastalığı görülme sıklığı. Akademik Gastroenteroloji Dergisi 2008;7:137‐43.