Colitis due to mycophenolate mofetil after liver transplantation: Case report
Yıl 2013,
Cilt: 12 Sayı: 2, 74 - 77, 01.08.2013
Zeynep Ebru Eser -
Serkan Yaraş -
Bünyamin Saritaş -
Fehmi Ateş
Engin Altıntaş
Ebru Serinsöz
Orhan Sezgin
Öz
Diarrhea is seen often after liver transplantation. Infectious agents and immunosuppressive therapy are generally the responsible factors for the development of diarrhea. Here, we report a case presenting with diarrhea who was diagnosed as colitis due to mycophenolate mofetil
Kaynakça
- Cox GJ, Matsui SM, Lo RS, et al. Etiology and outcome of diarrhea after marrow transplantation transplantation: a prospective study. Gastroenterology 1994; 107: 1398-407.
- Altiparmak MR, Trablus S, Pamuk ON, , et al. Diarrhoea following renal transplantation. Clin Transplant 2002; 16: 212-6.
- Wong NA, Bathgate AJ, Bellamy CO. Colorectal disease in liver al- lograft recipients-a clinicopathological study with follow-up. Eur J Gastroenterol Hepatol 2002;14:231-6.
- McFarland LV, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med 1989; 320: 204-10.
- Yassin SF, Young-Fadok TM, Zein NN, Pardi DS. Clostridium difficile- associated diarrhea and colitis. Mayo Clin Proc 2001; 76: 725-30.
- enteritis: an uncommon cause of diarrhoea in adult allogeneic and
- autologous stem cell transplant recipients. Bone Marrow Trans
- plant 2000; 26: 299-303.
- Goetz M, Eichenlaub S, Pape GR, Hoffmann RM. Chronic diarrhea as a result of intestinal microsposidiosis in a liver transplant recipi- ent. Transplantation 2001; 71: 334-7.
- Gerber DA, Green M, Jaffe R, et al. Cryptosporidial infections after solid organ transplantation in children. Pediatr Transplant 2000; 4: 50-5.
- Palau LA, Kemmerly SA. First report of invasive amebiasis in an organ transplant recipient. Transplantation 1997; 64: 936-7.
- Wiesner R, Rabkin J, Klintmalm G, et al. A randomized double-blind comparative study of mycophenolate mofetil and azathioprine in combination with cyclosporine and corticosteroids in primary liver transplant recipients. Liver Transpl 2001; 7: 442-50.
- Cantarovich M, Tzimas GN, Barkun J, et al. Efficacy of mycopheno- late mofetil combined with very low-dose cyclosporine microemul- sion in long-term liver-transplant patients with renal dysfunction. Transplantation 2003; 76: 98-102.
- Koch RO, Graziadei IW, Schulz F, et al. Long-term efficacy and safety of mycophenolate mofetil in liver transplant recipients with calcineurin inhibitor-induced renal dysfunction. Transpl Int 2004; 17: 518-24.
- Pfitzmann R, Klupp J, Langrehr JM, et al. Mycophenolatemofetil for immunosuppression after liver transplantation: a follow-up study of 191 patients. Transplantation 2003; 76: 130-6.
- Fairbanks KD, Thuluvath PJ. Mycophenolate mofetil monothera- py in liver transplant recipients: a single center experience. Liver Transpl 2004; 10: 1189-1194.
- Moreno JM, Rubio E, Gomez A, et al. Effectiveness and safety of mycophenolate mofetil as monotherapy in liver transplantation. Transplant Proc 2003; 35: 1874-6.
- Selbst MK, Ahrens WA, Robert ME, et al. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Mod Pathol 2009; 22: 737-43.
- U.S. Multicenter FK506 Liver Study Group. A comparison of ta- crolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. The U.S. Multicenter FK506 Liver Study Group. N Engl J Med 1994;331:1110-5.
- Levy G, Villamil F, Samuel D, et al. Results of lis2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation. Transplantation 2004;77:1632-8.
- Neff GW, Montalbano M, Tzakis AG. Ten years of sirolimus thera- py in orthotopic liver transplant recipients. Transplant Proc 2003; 35(Suppl 3): 209S-16S.
Karaciğer nakli sonrası mikofenolat mofetile bağlı kolit: Olgu sunumu
Yıl 2013,
Cilt: 12 Sayı: 2, 74 - 77, 01.08.2013
Zeynep Ebru Eser -
Serkan Yaraş -
Bünyamin Saritaş -
Fehmi Ateş
Engin Altıntaş
Ebru Serinsöz
Orhan Sezgin
Öz
Karaciğer nakli sonrası ishal sık olarak izlenmektedir. İshal gelişmesinden enfeksiyöz ajanlar ve nakil sonrası kullanılan immünsüpresif ajanlar sıklıkla sorumlu tutulmaktadır. Burada mikofenolat mofetil kullanımı sonrası ishal gelişen ve kolit saptanan bir olguyu sunacağız.
Kaynakça
- Cox GJ, Matsui SM, Lo RS, et al. Etiology and outcome of diarrhea after marrow transplantation transplantation: a prospective study. Gastroenterology 1994; 107: 1398-407.
- Altiparmak MR, Trablus S, Pamuk ON, , et al. Diarrhoea following renal transplantation. Clin Transplant 2002; 16: 212-6.
- Wong NA, Bathgate AJ, Bellamy CO. Colorectal disease in liver al- lograft recipients-a clinicopathological study with follow-up. Eur J Gastroenterol Hepatol 2002;14:231-6.
- McFarland LV, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med 1989; 320: 204-10.
- Yassin SF, Young-Fadok TM, Zein NN, Pardi DS. Clostridium difficile- associated diarrhea and colitis. Mayo Clin Proc 2001; 76: 725-30.
- enteritis: an uncommon cause of diarrhoea in adult allogeneic and
- autologous stem cell transplant recipients. Bone Marrow Trans
- plant 2000; 26: 299-303.
- Goetz M, Eichenlaub S, Pape GR, Hoffmann RM. Chronic diarrhea as a result of intestinal microsposidiosis in a liver transplant recipi- ent. Transplantation 2001; 71: 334-7.
- Gerber DA, Green M, Jaffe R, et al. Cryptosporidial infections after solid organ transplantation in children. Pediatr Transplant 2000; 4: 50-5.
- Palau LA, Kemmerly SA. First report of invasive amebiasis in an organ transplant recipient. Transplantation 1997; 64: 936-7.
- Wiesner R, Rabkin J, Klintmalm G, et al. A randomized double-blind comparative study of mycophenolate mofetil and azathioprine in combination with cyclosporine and corticosteroids in primary liver transplant recipients. Liver Transpl 2001; 7: 442-50.
- Cantarovich M, Tzimas GN, Barkun J, et al. Efficacy of mycopheno- late mofetil combined with very low-dose cyclosporine microemul- sion in long-term liver-transplant patients with renal dysfunction. Transplantation 2003; 76: 98-102.
- Koch RO, Graziadei IW, Schulz F, et al. Long-term efficacy and safety of mycophenolate mofetil in liver transplant recipients with calcineurin inhibitor-induced renal dysfunction. Transpl Int 2004; 17: 518-24.
- Pfitzmann R, Klupp J, Langrehr JM, et al. Mycophenolatemofetil for immunosuppression after liver transplantation: a follow-up study of 191 patients. Transplantation 2003; 76: 130-6.
- Fairbanks KD, Thuluvath PJ. Mycophenolate mofetil monothera- py in liver transplant recipients: a single center experience. Liver Transpl 2004; 10: 1189-1194.
- Moreno JM, Rubio E, Gomez A, et al. Effectiveness and safety of mycophenolate mofetil as monotherapy in liver transplantation. Transplant Proc 2003; 35: 1874-6.
- Selbst MK, Ahrens WA, Robert ME, et al. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Mod Pathol 2009; 22: 737-43.
- U.S. Multicenter FK506 Liver Study Group. A comparison of ta- crolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. The U.S. Multicenter FK506 Liver Study Group. N Engl J Med 1994;331:1110-5.
- Levy G, Villamil F, Samuel D, et al. Results of lis2t, a multicenter, randomized study comparing cyclosporine microemulsion with C2 monitoring and tacrolimus with C0 monitoring in de novo liver transplantation. Transplantation 2004;77:1632-8.
- Neff GW, Montalbano M, Tzakis AG. Ten years of sirolimus thera- py in orthotopic liver transplant recipients. Transplant Proc 2003; 35(Suppl 3): 209S-16S.