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The incidence of endoscopic celiac (gluten) disease in the Erzurum area in an adult population

Year 2013, Volume: 12 Issue: 1, 13 - 16, 01.04.2013

Abstract

Background and Aims:Celiac disease develops due to the effect of the gliadin fraction of wheat gluten, barley and rye proteins. Glutensensitive enteropathy is an autoimmune and familial illness that develops after malabsorption, which is due to dietary intake of some grain products. It can occur at any age (1–80 years of age). The prevalences have been reported as 0,05-0,2% in the general population in Europe, and 0,5-1% in the world. In this study, the incidence of gluten disease in an adult population in the Erzurum area was investigated with endoscopy. Materials and Methods:Between February-June 2010, the gastroscopy reports were examined retrospectively, and the endoscopic incidence of celiac disease and demographic characteristics of patients were investigated. Results:Gastroscopy was performed in a total of 1950 patients (924 [47%] males, mean age: 48,27±17,09 years [range: 14-100]). Celiac disease was detected in 7 patients (0,35%) by endoscopy (5 females (70%), 2 males (30%); mean age: 29,85±11,92 years, range: 17-49). Conclusions:In the Erzurum region, prevalence of celiac disease has been identified as 1 in about 280 patients, and these patients are often young and female.

References

  • Yenice N, Gümrah M, Kozan A. Asemptomatik hastalarda gluten sensitif enteropati seroprevelansı. Akademik Gastroenteroloji Der- gisi 2005;4:94-6.
  • Çoban S, Palabıyıkoğlu M, Örmeci N. Gluten sensitif enteropatili hastalarımızın değerlendirilmesi. Türkiye Klinikler J Gastroentero- hepatol 2003;14:147-50.
  • Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroentero. 2012;18:6036-59.
  • Rivera E, Assiri A, Guandalini S. Celiac disease. Oral Dis. 2013 Feb 26. doi: 10.1111/odi.12091. [Epub ahead of print]
  • Tavakkoli H, Haghdani S, Adilipour H, et al. Serologic celiac dis- ease in patients with inflammatory bowel disease. J Res Med Sci 2012;17:154-8.
  • Göral V, Yıldırım N, Kaplan A, et al. Gluten enteropatisi sıklığı. Aka- demik Gastroenteroloji Dergisi 2007;6:144-8.
  • Demirçeken FG. Gluten enteropatisi (Çölyak hastalığı): klasik bir öykü ve güncel gelişmeler. Güncel Gastroenteroloji 2011;15:58-72.
  • Caputo I, Lepretti M, Martucciello S, Esposito C. Enzymatic strat- egies to detoxify gluten: implications for celiac disease. SAGE- Hindawi Access to Research Enzyme Research. Volume 2010 Ar- ticle ID 174354, 9 pages doi:10.4061/2010/174354.
  • Akın M, Songür Y, Aksakal G. Clinical and laboratory features and extraintestinal manifestations of celiac disease in adults. J Clin Anal Med 2012;3:194-7.
  • Sainsbury A, Sanders DS, Ford AC. Prevalence of irritable bowel syndrome-type symptoms in patients with celiac disease: a meta- analysis. Clin Gastroenterol Hepatol 2013;11:359-65.e1. Epub 2012 Dec 13.
  • Ludvigsson JF. Mortality and malignancy in celiac disease. Gastroin- test Endosc Clin N Am 2012;22:705-22. Epub 2012 Aug 20.
  • Rubio-Tapia A, Hill ID, Kelly CP, et al. ACG clinical guidelines: di- agnosis and management of celiac disease. Am J Gastroenterol 2013;108:656-76. Epub 2013 Apr 23.
  • Aljebreen AM, Almadi MA, Alhammad A, Al Faleh FZ. Seropreva- lence of celiac disease among healthy adolescents in Saudi Arabia. World J Gastroenterol 2013;19:2374-8.
  • Özdil K, Erer B, Tekeşin K, Seymen Yılmaz M. Fonksiyonel dispepsili hastalarda duodenal ve antral biopsi sonuçlarının değerlendirilmesi. Turkiye Klinikleri J Gastroenterohepatol 2010;17:20-4.
  • Ludvigsson JF, Rubio-Tapia A, van Dyke CT, et al. Increasing inci- dence of celiac disease in a north american population. Am J Gas- troenterol 2013;108:818-24. Epub 2013 Mar 19.
  • Almeida LM, Castro LC, Uenishi RH, et al. Decreased prevalence of celiac disease among Brazilian elderly. World J Gastroenterol 2013;19:1930-5.
  • Kocsis D, Miheller P, Lörinczy K, et al. Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral cen- tre. Eur J Intern Med 2013;24:461-7. Epub 2013 Mar 24.
  • Carter D, Levi G, Tzur D, et al. Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron defi- ciency anemia. Dig Dis Sci 2013;58:1299-305. Epub 2012 Nov 29.
  • Çekin AH, Çekin Y, Sezer C. Celiac disease prevalence in patients with iron deficiency anemia. Turk J Gastroenterol 2012;23:490-5.

Erzurum ve çevresinde erişkin popülasyonunda endoskopik çölyak (gluten) hastalığı sıklığı.

Year 2013, Volume: 12 Issue: 1, 13 - 16, 01.04.2013

Abstract

Giriş ve Amaç: Çölyak (gluten) hastalığı buğday, arpa, yulaf, çavdar gibi tahıllardaki glutende bulunan gliadinin etkisi ile malabsorsiyona neden olan, otoimmün ve familial özellikleri olan bir hastalıktır. Her yaşta ortaya çıkabilir (1 yaşından 80 yaşına kadar). Genel nüfusta prevalansı Avrupa'da %0,05-0,2, Dünyada 0,5-1%'dir. Bu çalışmada Erzurum ve çevresinde erişkin nüfusta endoskopik olarak tesbit edilen, çölyak hastalığı sıklığının araştırılması amaçlanmıştır. Gereç ve Yöntem: Şubat-Haziran 2010 tarihleri arasında ünitemizde çeşitli nedenlerle gastroskopisi yapılan hastalar retrospektif olarak incelenerek, gluten hastalığının endoskopik sıklığı ve gluten saptanan hastaların demografik özellikleri araştırıldı. Bulgular:Gastroskopileri taranan toplam 1950 hastanın 924'ü (%47) erkek, yaş ortalaması 48.27±17.09 yaş (dağılım 14-100) idi. Yedi hastada (%0.035) endoskopik olarak gluten saptanmış olup, yaş ortalaması 29.85±11.92 (dağılım 17-49), 5'i kadın (%70), 2'si erkek (%30) idi. Sonuç: Erzurum ve bölgesinde gastroskopi yapılan popülasyonda çölyak hastalığı sıklığı yaklaşık 280 hastada bir olarak tesbit edilmiş olup, bu hastalar sıklıkla genç yaşta ve kadındır.

References

  • Yenice N, Gümrah M, Kozan A. Asemptomatik hastalarda gluten sensitif enteropati seroprevelansı. Akademik Gastroenteroloji Der- gisi 2005;4:94-6.
  • Çoban S, Palabıyıkoğlu M, Örmeci N. Gluten sensitif enteropatili hastalarımızın değerlendirilmesi. Türkiye Klinikler J Gastroentero- hepatol 2003;14:147-50.
  • Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroentero. 2012;18:6036-59.
  • Rivera E, Assiri A, Guandalini S. Celiac disease. Oral Dis. 2013 Feb 26. doi: 10.1111/odi.12091. [Epub ahead of print]
  • Tavakkoli H, Haghdani S, Adilipour H, et al. Serologic celiac dis- ease in patients with inflammatory bowel disease. J Res Med Sci 2012;17:154-8.
  • Göral V, Yıldırım N, Kaplan A, et al. Gluten enteropatisi sıklığı. Aka- demik Gastroenteroloji Dergisi 2007;6:144-8.
  • Demirçeken FG. Gluten enteropatisi (Çölyak hastalığı): klasik bir öykü ve güncel gelişmeler. Güncel Gastroenteroloji 2011;15:58-72.
  • Caputo I, Lepretti M, Martucciello S, Esposito C. Enzymatic strat- egies to detoxify gluten: implications for celiac disease. SAGE- Hindawi Access to Research Enzyme Research. Volume 2010 Ar- ticle ID 174354, 9 pages doi:10.4061/2010/174354.
  • Akın M, Songür Y, Aksakal G. Clinical and laboratory features and extraintestinal manifestations of celiac disease in adults. J Clin Anal Med 2012;3:194-7.
  • Sainsbury A, Sanders DS, Ford AC. Prevalence of irritable bowel syndrome-type symptoms in patients with celiac disease: a meta- analysis. Clin Gastroenterol Hepatol 2013;11:359-65.e1. Epub 2012 Dec 13.
  • Ludvigsson JF. Mortality and malignancy in celiac disease. Gastroin- test Endosc Clin N Am 2012;22:705-22. Epub 2012 Aug 20.
  • Rubio-Tapia A, Hill ID, Kelly CP, et al. ACG clinical guidelines: di- agnosis and management of celiac disease. Am J Gastroenterol 2013;108:656-76. Epub 2013 Apr 23.
  • Aljebreen AM, Almadi MA, Alhammad A, Al Faleh FZ. Seropreva- lence of celiac disease among healthy adolescents in Saudi Arabia. World J Gastroenterol 2013;19:2374-8.
  • Özdil K, Erer B, Tekeşin K, Seymen Yılmaz M. Fonksiyonel dispepsili hastalarda duodenal ve antral biopsi sonuçlarının değerlendirilmesi. Turkiye Klinikleri J Gastroenterohepatol 2010;17:20-4.
  • Ludvigsson JF, Rubio-Tapia A, van Dyke CT, et al. Increasing inci- dence of celiac disease in a north american population. Am J Gas- troenterol 2013;108:818-24. Epub 2013 Mar 19.
  • Almeida LM, Castro LC, Uenishi RH, et al. Decreased prevalence of celiac disease among Brazilian elderly. World J Gastroenterol 2013;19:1930-5.
  • Kocsis D, Miheller P, Lörinczy K, et al. Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral cen- tre. Eur J Intern Med 2013;24:461-7. Epub 2013 Mar 24.
  • Carter D, Levi G, Tzur D, et al. Prevalence and predictive factors for gastrointestinal pathology in young men evaluated for iron defi- ciency anemia. Dig Dis Sci 2013;58:1299-305. Epub 2012 Nov 29.
  • Çekin AH, Çekin Y, Sezer C. Celiac disease prevalence in patients with iron deficiency anemia. Turk J Gastroenterol 2012;23:490-5.
There are 19 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ahmet Uyanıkoğlu This is me

Muharrem Coşkun - This is me

Doğan Nasır Binici This is me

Yasin Öztürk This is me

Publication Date April 1, 2013
Published in Issue Year 2013 Volume: 12 Issue: 1

Cite

APA Uyanıkoğlu, A., -, M. C., Binici, D. N., Öztürk, Y. (2013). Erzurum ve çevresinde erişkin popülasyonunda endoskopik çölyak (gluten) hastalığı sıklığı. Akademik Gastroenteroloji Dergisi, 12(1), 13-16.

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