Orlistat-induced acute pancreatitis

Yıl 2012, Cilt: 11 Sayı: 2, 90 - 91, 01.08.2012

Zahide Şimşek Akif Altınbaş Hatice Karaköse Doğan Alper Dilli Ömer Başar

Öz

Drug-induced pancreatitis is a rare but important cause of pancreatic injury. Orlistat is a pancreatic lipase inhibitor licensed for the treatment of obesity. We present a case of orlistat- induced mild acute pancreatitis that developed 8 days after starting treatment.

Anahtar Kelimeler

Key words: Obesity, orlistat, pancreatitis

Orlistat tedavisine bağlı akut pankreatit

Öz

ilaca bağlı pankreatit vakaları nadirdir, fakat önemli derecelerde pankreatik hasara sebep olabilirler. Orlistat, obezite tedavisinde kullanılan pankreatik lipaz inhibitörüdür. Orlistat ile obezite tedavisine başlandıktan sonraki 8. günde gözlenen hafif derecede akut pankreatit vakasını sunduk.

Anahtar Kelimeler

Obezite, orlistat, pankreatit

Kaynakça

• Carriere F, Renou C, Ransac S, et al. Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volun- teers. Am J Physiol Gastrointest Liver Physiol 2001; 281: G16-28.
• Wilmink T, Frick TW. Drug-induced pancreatitis. Drug Safety 1996; : 406-23.
• Napier S, Thomas M. 36 year old man presenting with pancreati- tis and a history of recent commencement of orlistat case report. Nutr J 2006; 5: 19.
• Ahmad FA, Mahmud S. Acute pancreatitis following orlistat the- rapy: report of two cases. JOP 2010; 11: 61-3.